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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Study of the interfaces between austenite and ferrite grains in P/M duplex stainless steels 显示文摘 | Campos M Bautista A Caceres D | 2003 | Journal of the European Ceramic Society2003，23，15： | 1 |
| 3 | A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma显示文摘 | Caceres A I Brackmann M Ella M D | 2009 | Proc Natl Acad Sci U S A2009，106，22： | 1 |
| 4 | Organic Farming and the Sustainability of Agricultural Systems 显示文摘 | RIGBY D CACERES D | 2001 | Agriculture System2001，68，1： | 1 |
| 5 | Design of a new cooked meat sausage riched with calcium显示文摘 | Caceres E Garcia M L Selgas M D | 2006 | Meat Science2006，，73： | 1 |
| 6 | Long-chain solu- ble dietary fibre as functional ingredient in cooked meat sausages 显示文摘 | Selgas M D Caceres E Garcia M L | 2005 | Food Science and Technology Internation- al2005，11，1： | 1 |
| 7 | Microporosity formation in Al-Si-Cu-Mg casting alloys 显示文摘 | Sigworth G K Caceres C H St John D H Barresi J | 1997 | AFS Trans1997，105，： | 1 |
| 8 | Mechanical behaviour of the interphase between matrix and reinforcement of A1 2014 matrix composites reinforced with (Ni3A1)p 显示文摘 | TORRALBA J M VELASCO F COSTA C E VERGARA I CACERES D | 2002 | Composites Part A: Applied Science and Manufacturing2002，33，： | 1 |
| 9 | Functional characterization of SR and SR-related genes in Caenorhabditis elegans显示文摘 | LONGMAN D JOHNSIDNE I L CACERES J F | 2000 | EMBO J2000，19，7： | 1 |
| 10 | Study of the interfaces between austenite and ferrite grains in P/M duplex stainless steels显示文摘 | Campos M Bautista A Caceres D | 2003 | Journal of the European Ceramic Society2003，23，15： | 1 |
| 11 | Microstructural characterization of MgO thin films grown by radiofrequency sputtering 显示文摘 | Caceres D Vergara I Gonzalez R | 2003 | J Appl Phys2003，93，7： | 1 |
| 12 | Effect of pre-emulsified fish oil-as source of PUFA n-3-on microstructure and sensory properties of mortadella,a Spanish bologna-type sausage显示文摘 | Caceres E Garcia M L Selgas M D | | 0，，： | 1 |
| 13 | Radiation damage in neutron-irradiated yttria-stabilized-zirconia single crystals显示文摘 | Savoini B Caceres D Vergara I | 2000 | J Nucl Mater2000，277，： | 1 |
| 14 | Microstructural characterization of MgO thin films grown by radio-frequency sputtering 显示文摘 | Caceres D Vergara I Gonzalez R | 2003 | Journal of Applied Physics2003，93，7： | 1 |
| 15 | Study of the interfaces between austenite and ferrite grains in P/M duplex stainless steels显示文摘 | Campos M Bautista A Caceres D | 2003 | Journal of the European Ceramic Society2003，23，2003： | 1 |
| 16 | Solid solution strengthening in concentrated Mg-Al alloys显示文摘 | CACERES C H ROVERA D M | 2001 | Journal of Light Metals2001，21，： | 1 |
| 17 | TVDc: Managing security in the trusted virtual datacenter显示文摘 | BERGER S CACERES R PENDARAKIS D | 2008 | ACM SlOOPS Operating Systems Review2008，42，1： | 1 |
| 18 | Alloy selection for die castings using the quality index显示文摘 | Caceres C H Wang L Apelian D | 1999 | AFS Transactions1999，147，： | 1 |
| 19 | A layered approach tosimplified access control in virtualized systems显示文摘 | PAYNE B D SAILER R CACERES R | 2007 | ACM SIGOPSOperating Systems Review2007，41，4： | 1 |
| 20 | Thermal energy storage : 'How previous findings determine current research priorities' 显示文摘 | Fernandes D Pitie F Caceres G | 2012 | Energy2012，39，1： | 1 |
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