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| 1 | Metabolomic Profiling in Selaginella lepidophylla at Various Hydration States Provides New Insights into the Mechanistic Basis of Desiccation Tolerance显示文摘Selaginella lepidophylla 是仅仅一些之一发展了干燥忍耐(DT ) 或从一个 air-dried 状态复兴的能力的尖铁苔藓(Selaginellaceae ) 的种类。以便理解 DT 的新陈代谢的基础, S。lepidophylla 受到一五阶段, rehydration/dehydration 周期,然后分析了使用基于 GC/MS 和 UHLC/MS/MS2 平台介绍技术的非偏导的、全球 metabolomics。包括 167 说出的 251 代谢物(66.5%) 的一个总数并且 84 (33.4%) 未命名的混合物被描绘。仅仅 42 (16.7%) 并且(29.5%) 74 混合物显示出显著地增加或减少的丰富分别地,显示大多数混合物组成地被生产包括高度丰富的 trehalose,蔗糖,和葡萄糖。几 glycolysis/gluconeogenesis 和 tricarboxylic 酸(TCA ) 周期中介在 100% 亲戚水内容(RWC ) 和 50% RWC 显示出增加的丰富。Vanillate,一种有势力抗氧化剂,也更充满含水的状态。许多不同的糖白酒和糖酸更充满含水的状态。这些 polyols 多半速度率在水和期间在弄干的过程以及慢水吸收期间浇损失,稳定蛋白质,并且清除反应的氧种类(ROS ) 。相反,充满氮并且 -glutamyl 氨基酸,瓜氨酸,和核苷酸分解代谢产品(例如 allantoin ) 更充满干燥状态,建议这些混合物可能在水和期间或在清除的 ROS 在氮动员起重要作用。紫外保护的混合物象 3-(3-hydroxyphenyl ) 那样 propionate, apigenin,和 naringenin,更充满干燥状态。大多数类脂化合物组成地被生产,与胆碱磷酸盐的例外,它更充满干燥状态并且多半在膜水和和稳定起一个作用。相反,几多元不堡和丰满的酸更充满含水的状态,建议这些混合物多半帮助在脱水期间维持膜流动性。最后, S。lepidophylla 包含了显示了双重或更大的丰富在的七未命名的混合物干燥或 rehydrating 状态,建议这些混合物可能在 DT 起适应作用。 | Abou Yobi Bernard W.M. Wone Wenxin Xu Danny C. Alexander Lining Guo John A. Ryals Melvin J. Oliver John C. Cushman | 2013 | Molecular Plant2013，6，2： | 9 |
| 2 | Resistance gene-analog polymorphism markers co-segregating with the YR5 gene for resistance to wheat stripe rust显示文摘 | G. Yan X. Chen R. Line C. Wellings | 2003 | Theoretical and Applied Genetics2003，，4： | 1 |
| 3 | Resistance gene-analog polymorphism markers co-segregating with the YR5 gene for resistance to wheat stripe rust显示文摘 | G. Yan X. Chen R. Line C. Wellings | 2003 | Theoretical and Applied Genetics2003，，4： | 1 |
| 4 | Overlap of Diseases Underlying Ischemic Stroke显示文摘 | Gaia Sirimarco Philippa C. Lavallée Julien Labreuche Elena Meseguer Lucie Cabrejo Céline Guidoux Isabelle F. Klein Jean-Marc Olivot Halim Abboud Valérie Adra? Jér?me Kusmierek Samina Ratani Pierre-Jean Touboul Mikael Mazighi Philippe Gabriel Steg Pierre A | 2013 | Stroke2013，，9： | 1 |
| 5 | Pseudorabies virus US3- and UL49.5-dependent and -independent downregulation of MHC I cell surface expression in different cell types显示文摘 | Matthias J. Deruelle Céline Van den Broeke Hans J. Nauwynck Thomas C. Mettenleiter Herman W. Favoreel | 2009 | Virology2009，，2： | 1 |
| 6 | 罗非考昔在急性偏头痛治疗中的作用:一项随机对照临床试验显示文摘Objective. -To investigate the efficacy, tolerability, and safety of rofecoxib and ibuprofen for acute migraine treatment. Background. -Rofecoxib was effective and well tolerated in a previous study of treatment of a single migraine attack. We sought to replicate these findings for a single attack and also study the clinical profile of rofecoxib in the acute treatment of multiple migraine attacks. Ibuprofen was included as a reference nonselective NSAID. Methods. -Adult migraineurs (n = 783) treated one migraine attack with either rofecoxib (25 or 50 mg), ibuprofen 400 mg, or placebo in a randomized, double-blind study. Patients could elect to enroll in a 3-month double-blind extension phase. Results. -In the single-attack phase, headache relief at 2 hours postdose was reported by 59.4%, 62.2%, and 57.7%of patients who took rofecoxib 25 mg, rofecoxib 50 mg, and ibuprofen 400 mg, respectively, versus 30.5%for placebo (all P < .001 vs placebo). The active drugs were statistically superior to placebo on a variety of additional measures. In the extension phase, the mean percentage of patients‘attacks with headache relief at 2 hours postdose was 61.8%for rofecoxib 25 mg, 65.4%for rofecoxib 50 mg, and 59.3%for ibuprofen 400 mg. The mean percentage of patients’attacks with 24-hour sustained headache relief was greater for rofecoxib 50 mg (52.0%) than for rofecoxib 25 mg (47.8%, P < .050) or ibuprofen (39.0%, P < .010). In the single-attack phase, the adverse event rate was higher for rofecoxib 50 mg (37.8%) than placebo (27.8%, P < .050); rates were similar to placebo for rofecoxib 25 mg (32.0%, n.s.) and ibuprofen 400 mg (28.1%, n.s.). In the extension phase, treatment groups had similar adverse event rates. Conclusions. -Rofecoxib 25 and 50 mg and ibuprofen 400 mg were effective and generally well tolerated in the acute treatment of migraine. | Saper J. Dahlof C. So Y C. Lines 樊慧婷 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 1 |
| 7 | Plasma metabolomic profile in nonalcoholic fatty liver disease显示文摘 | Satish C. Kalhan Lining Guo John Edmison Srinivasan Dasarathy Arthur J. McCullough Richard W. Hanson Mike Milburn | 2011 | Metabolism2011，，3： | 1 |
| 8 | A waste characterisation procedure for ADM1 implementation based on degradation kinetics显示文摘 | R. Girault G. Bridoux F. Nauleau C. Poullain J. Buffet J.-P. Steyer A.G. Sadowski F. Béline | 2012 | Water Research2012，，13： | 1 |
| 9 | First evidence of large-scale PAH trends in French soils显示文摘 | Estelle J. Villanneau Nicolas P. A. Saby Thomas G. Orton Claudy C. Jolivet Line Boulonne Giovanni Caria Enrique Barriuso Antonio Bispo Olivier Briand Dominique Arrouays | 2013 | Environmental Chemistry Letters2013，，1： | 1 |
| 10 | Outcomes after thrombolysis in AIS according to prior statin use: A registry and review显示文摘 | Elena Meseguer Mikael Mazighi Bertrand Lapergue Julien Labreuche Gaia Sirimarco Jaime Gonzalez-Valcarcel Philippa C. Lavallée Lucie Cabrejo Céline Guidoux Isabelle F. Klein Jean-Marc Olivot Aymeric Rouchaud Jean-Philippe Desilles Pierre Amarenco | 2012 | Neurology2012，，17： | 1 |
| 11 | Dynamics of Hippocampal Neurogenesis in Adult Humans显示文摘 | Kirsty L. Spalding Olaf Bergmann Kanar Alkass Samuel Bernard Mehran Salehpour Hagen B. Huttner Emil Bostr?m Isabelle Westerlund Céline Vial Bruce A. Buchholz G?ran Possnert Deborah C. Mash Henrik Druid Jonas Frisén | 2013 | Cell2013，，6： | 1 |
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