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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Effect of Adiponectin and Ghrelin on Apoptosis of Barrett Adenocarcinoma Cell Line显示文摘 | Peter C. Konturek Grzegorz Burnat Tilman Rau Eckhart G. Hahn Stanislaw Konturek | 2008 | Digestive Diseases and Sciences2008，，3： | 2 |
| 3 | Role of brain-gut axis in healing of gastric ulcers 显示文摘 | Konturek P C Brzozowski B Burnat G | 2004 | J Physiol Pharmacol2004，55，1： | 1 |
| 4 | Bile acids induce overexpression of ho-meobox gene CDX-2 and vascular endothelial growth factor (VEGF) in hu-man Barrett , s esophageal mucosa and adenocarcinoma cell line 显示文摘 | Burnat G Rau T Elshimi E | 2007 | Scand J Gastroenterol2007，42，12： | 1 |
| 5 | Gastric ulcer healing and stress-lesion preventive properties of pioglitazone are attenuated in diabetic rats显示文摘 | Konturek PC Brzozowski T Burnat G | | 0，，04： | 1 |
| 6 | Mice lacking canna- binoid CB1 - , CB2 - receptors or both receptors show increased susceptibility to trenitrobenzene sulfonic acid (TNBS) -induced co- litis 显示文摘 | Engel M A Kellermann C A Burnat G | 2010 | J Physiol Pharmaco12010，61，1： | 1 |
| 7 | Bile acids are multifunctional modulators of the Barrett' s carcinogenesis 显示文摘 | Burnat G Majka J Konturek PC | 2010 | J Physiol Pharmacol2010，61，2： | 1 |
| 8 | Flame-made visible light active Ti02 : Cr photocatalysts Correlation be- tween structural, optical and photocatalytic properties显示文摘 | Michalow K A Otal E H Burnat D | 2013 | Catal Today2013，209，： | 1 |
| 9 | Inhibition of Barret's adenocarcinoma cell growth by simvastatin:involvement of COX-2 and apoptosis-related proteins显示文摘 | Konturek PC Burnat G Hahn EC | 2007 | J Physiol Pharmacol2007，58，3： | 1 |
| 10 | Inhibition of Barret' s adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis related proteins显示文摘 | Konturek PC Burnat G Hahn EG | 2007 | J Physiol Pharmacol2007，58，3： | 1 |
| 11 | High-performance liquid chromatographic determination of modafinil and its two metabolites in human plasma using solid-phase extraction 显示文摘 | Burnat P Robles F Do B | 1998 | J Chromatogr B Biomed Sci Appl1998，706，2： | 1 |
| 12 | High-performance liquid chromatographic determination of modafinil and its two metabolites in human plasma using solid-phase extraction显示文摘 | BURNAT P ROBLES F DO B | 1998 | J Chromatogr B Biomed Sci Appl1998，706，2： | 1 |
| 13 | High performance liquid chroma tography determination of modafinil and its two metabolites in human plasma using solid-phase extraction显示文摘 | Burnat P Robles F Do B | 1998 | Chromatogr B Biomed Sci Appl1998，706，2： | 1 |
| 14 | Gastric ulcer healing andstress-lesion preventive properties of pioglitazone are attenuated in dia-betic rats显示文摘 | Konturek PC Brzozowski T Burnat G | 2010 | J Physiol Pharmacol2010，61，4： | 1 |
| 15 | Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line显示文摘 | Konturek PC Burnat G Rau T | 2008 | Dig Dis Sci2008，53，3： | 1 |
| 16 | Effects of cyclooxygenase-2 inhibition on serum and tumor gastrins and expression of apop- tosis-related proteins in colorectalcancer 显示文摘 | Konturek PC Rembiasz K Burnat G | 2006 | Dig Dis Sci2006，51，4： | 1 |
| 17 | Age-dependent alterations in CRMP2 and CRMP4 protein expression profiles in cat visual cortex 显示文摘 | Cnops L Hu TT Burnat K | 2006 | BrainRes2006，1088，1： | 1 |
| 18 | Dynamic physiological and molecular changes in gastric ulcer healing aehieved by melatonin and its precursor L-tryptophan in rats显示文摘 | Konturek PC Konturek S J Burnat G | 2008 | J Pineal Res2008，45，2： | 1 |
| 19 | E valuation of stratus CS stat fluorimetric analyzer for measure ment of cardiac markers troponin (cTnI), creatine kinase (CKMB), and myoglobin显示文摘 | BURNAT B B BAUDIN B VAUBOURDOLL M | 2001 | Journal of Clincal Laboratory Analysis2001，15，6： | 1 |
| 20 | Mice lackingcannabinoid CB1-,CB2-receptors or both receptors showincreased susceptibility to trinitrobenzene sulfonic acid(TNBS)-induced colitis显示文摘 | Engel MA Kellermann CA Burnat G | 2010 | J Physiol Pharmacol2010，61，1： | 1 |
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