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| 1 | Acute and subacute oral toxicity of Litsea elliptica Blume essential oil in rats显示文摘Litsea elliptica Blume has been traditionally used to treat headache,fever,and stomach ulcer,and has also been used as an insect repellent.The acute and subacute toxicities of L.elliptica essential oil were evaluated orally by gavage in female Sprague-Dawley rats.For the acute toxicity study,L.elliptica essential oil was administered in doses from 500 to 4 000 mg/kg(single dose),and in the subacute toxicity test,the following doses were used:125,250,and 500 mg/kg,for 28 consecutive days.In the acute toxicity study,L.elliptica essential oil caused dose-dependent adverse behaviours and mortality.The median lethal dose value was 3 488.86 mg/kg and the acute non-observed-adversed-effect level value was found to be 500 mg/kg.The subacute toxicity study of L.elliptica essential oil did not reveal alterations in body weight,and food and water consumptions.The haematological and biochemical analyses did not show significant differences between control and treated groups in most of the parameters examined,except for the hemoglobin,mean cell hemoglobin concentration,mean cell volume,mean cell hemoglobin,serum albumin,and serum sodium.However,these differences were still within the normal range.No abnormalities or histopathological changes were observed in the liver,pancreatic islet of Langerhans,and renal glomerulous and tubular cells of all treated groups.In conclusion,L.elliptica essential oil can be classified in the U group,which is defined as a group unlikely to present an acute hazard according to World Health Organization(WHO) classification. | Siti Balkis BUDIN Seri Masran SITI NOR AIN Baharuddin OMAR Izatus Shima TAIB Othman HIDAYATULFATHI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 2 |
| 2 | Breast cancer education, counseling, and adjustment among patients and partners : a randomized clinical trial 显示文摘 | Budin WC Hoskins CN Haber J | 2008 | Nurs Res2008，57，3： | 1 |
| 3 | Whiplash fractures of cervicodorsal spinous processes:Resemblance to shoveler's fracture显示文摘 | Gershon-Cohen J Budin E Glauser F | 1954 | JAMA1954，155，6： | 1 |
| 4 | Nitrogen fixation associated with rinsed roots and rhizomes of the eelgrass zostera marina 显示文摘 | Capone D G Budin J M | 1982 | Plant Physiology1982，70，60： | 1 |
| 5 | PCDD- and PCDFdestructionby a SCR-unit in a municipal waste incinerator显示文摘 | Boos R Budin R Hartl H | 1992 | Chemosphere1992，25，3： | 1 |
| 6 | The role of oxidativestress and antioxidants in diabetic complications 显示文摘 | Matough FA Budin SB Hamid ZA | 2012 | Sultan QaboosUniv Med J2012，12，1： | 1 |
| 7 | The role of ox- idative stress and antioxidants in diabetic compli- cations显示文摘 | Matough FA Budin SB Hamid ZA | 2012 | Sultan Qaboos Oniv Med J2012，12，1： | 1 |
| 8 | Prevention and Management of Product Recalls in the Processed Food Industry:A Case Study Based on an Exporter's Perspective 显示文摘 | KUMAR S BUDIN E M | 2006 | Teehnova-tion2006，26，5： | 1 |
| 9 | Prospects of a Philosophy of Terminology显示文摘 | Budin G | 2003 | Terminology Science and Research2003，，14： | 1 |
| 10 | A Critical Evaluation of the State-of-the-Art of Terminology Theory显示文摘 | Budin G | 2000 | Terminology Science and Research2000，，11： | 1 |
| 11 | Immunization with α-galactosylce-ramide polarizes CDld-reactive NKT cells towards Th2 cytokine synthe-sis显示文摘 | Brossay L Kronenberg M | 1999 | Eur J Immunol1999，29，： | 1 |
| 12 | Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats 显示文摘 | Balkis Budin S Othman F Louis SR | 2009 | Rom J Morphol Embryol2009，50，1： | 1 |
| 13 | Use of capsule endoscopy in children with primary intestinal lymphangiectasia 显示文摘 | Rivet C Lapalus MG Dumortier J Gall CL Budin C Bouvier R | 2006 | Gastrointest Endosc2006，64，4： | 1 |
| 14 | High-speed penetration into sand显示文摘 | Savvateev A F Budin A V Kolikov V A | 2001 | International Journal ofImpact Engineering2001，26，12345678910： | 1 |
| 15 | Investigation of anode and jets influence on electric arc properties with current up to 500 kA显示文摘 | BOGOMAZ A A BUDIN A V KOLIKOV V A | 2002 | IEEE Transaction on Plasma Science2002，16，2： | 1 |
| 16 | The role of oxidative stress and antioxidants in diabetic eomplieations显示文摘 | Matough FA Budin SB Hamid ZA | 2012 | Suhan Qaboos Univ Med J2012，12，1： | 1 |
| 17 | Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats显示文摘Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties. | Zariyantey ABDUL HAMID Siti Balkis BUDIN Ng WEN JIE Asmah HAMID Khairana HUSAIN Jamaludin MOHAMED | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，3： | 1 |
| 18 | The role of oxi- dative stress and antioxidants in diabetic complications 显示文摘 | Matough FA Budin SB Hamid ZA | 2012 | Sultan Qaboos Univ Med J2012，12，1： | 1 |
| 19 | On the existence of positive solutions for a class of semilinear elliptic boundary value problems显示文摘 | BROWN K J BUDIN H | 1979 | SIAM Journal on Mathematical Analysis1979，10，5： | 1 |
| 20 | Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male Sprague-Dawley rats显示文摘 | Taib IS Budin SB Ghazali AR | 2013 | Clinics2013，68，： | 1 |
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