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| 1 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 2 | Association analysis of candidate genes for maysin and chlorogenic acid accumulation in maize silks显示文摘 | S. J. Szalma E. S. Buckler M. E. Snook M. D. McMullen | 2005 | Theoretical and Applied Genetics2005，，7： | 2 |
| 3 | Observing the stages of bystander intervention in virtual reality simulation显示文摘BACKGROUND: Understanding bystander reactions to an emergency is an important component of effective training. Four stages of bystander intervention (BI) have been previously described: noticing the situation as a problem, interpreting when it is appropriate to intervene, recognizing personal responsibility to intervene, and knowing how to intervene. Using virtual reality (VR) to simulate emergencies such as sudden cardiac arrest (SCA) can be used to study these stages. METHODS: In a secondary analysis of an observational cohort study, we analyzed bystander self-effi cacy for stages of BI before and after simulated SCA. Each subject participated in a singleplayer, immersive, VR SCA scenario. Subjects interacted with simulated bystanders through voice commands (“call 911”,“get an AED”). Actions taken in scenario, like performing CPR, were documented. Scenario BI actions were compared based on dichotomized comfort/discomfort. RESULTS: From June 2016 to June 2017, 119 subjects participated. Average age was 37±14 years, 44% were female and 46% reported CPR training within 2 years. During the scenario, 98%“noticed the event” and “interpreted it as a problem”, 78%“took responsibility”, and 54%“possessed the necessary skills”. Self-effi cacy increased from pre- to post-scenario: noticing the event increased from 80% to 96%;interpreting as a problem increased from 86% to 97%;taking responsibility increased from 56% to 93%;possessing necessary skills increased from 47% to 63%(P<0.001). CONCLUSION: Self-efficacy to respond to an SCA event increased pre- to post-scenario. Bystanders who reported feeling comfortable “taking responsibility to intervene” during an emergency were more likely to take action during a simulated emergency. | David G. Buckler Alfredo Almodovar Jr Paul Snobelen Benjamin S. Abella Audrey Blewer Marion Leary | 2019 | World Journal of Emergency Medicine2019，10，3： | 2 |
| 4 | Association mapping: critical considerations shift from genotyping to experimental design 显示文摘 | Myles S Peiffer J Brown P J Ersoz E S Zhang Z Costich D E Buckler E S | 2009 | The Plant Cell Online2009，21，8： | 1 |
| 5 | TheV -TempTM Economizer System and Method for SCRTemperature Control显示文摘 | M J ALBRECHT J T BUCKLER’S A SCAVUZZO | 2011 | Technical Paper2011，，3： | 1 |
| 6 | Molecular diversity,structure and domestication of grasses 显示文摘 | Buckler E S Thornsberry J M Kresovich S | 2001 | Genet Res2001，77，： | 1 |
| 7 | The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions 显示文摘 | KESSLER L G BARNHART H X BUCKLER A J | 2014 | Stat Methods Med Res2014，24，1： | 1 |
| 8 | Altered Ca2 + handling in ventricular myocytes isolated from diabetic rats显示文摘 | Lagadic- Gossmann D Buckler K J Le Prigent K | 1996 | Am J Physiol1996，270，5： | 1 |
| 9 | Follicle stimulating hormone and its receptor: future perspectives 显示文摘 | Chappel S Buckler D Kelton C | 1998 | Hum Reprod1998，133，： | 1 |
| 10 | Dwarf8 polymorphisms associate with variation in flowering time显示文摘 | Thornsberry J M Goodman M M Buckler E S | 2001 | Nature Genetics2001，28，： | 1 |
| 11 | Follicle stimulating hormone and its receptor: future perspectives 显示文摘 | Chappel S Buckler D Kelton C | | discussion0，4751，： | 1 |
| 12 | Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima 显示文摘 | Buckler D R Zhou Y Stock A M | 2002 | Structure2002，10，2： | 1 |
| 13 | Genetic association mapping and genome organization of maize 显示文摘 | Yu J Buckler E S | 2006 | Current Opinion in Biotechnology2006，17，2： | 1 |
| 14 | Well remediation using expandable cased-hole liners 显示文摘 | Merritt R M Gusevik R Buckler W etc | 2002 | World Oil2002，32，： | 1 |
| 15 | The menopause transition endocrine changes and clinical symptoms 显示文摘 | BUCKLER H | 2012 | Br Menopause Soc2012，，11： | 1 |
| 16 | Status and prospects of association mapping in plants 显示文摘 | ZHU C S GORE M BUCKLER E S | 2008 | The Plant Genome2008，1，1： | 1 |
| 17 | The Spiritual Nature of Innovation显示文摘 | Buckler S A | 1998 | Technology Management1998，，4： | 1 |
| 18 | Genetic association mapping and genome organization of maize 显示文摘 | YU J M BUCKLER E S | 2006 | Current Opinion in Biotechnology2006，17，2： | 1 |
| 19 | The menopause transition: endocrine changes and clinical symptoms 显示文摘 | Buckler H | 2005 | J Br Menopause Soc2005，11，： | 1 |
| 20 | PTEN inhibitsIL-2 receptor-mediated expansion of CD4 + CD25 + Tregs显示文摘 | Walsh PT Buckler JL Zhang J | 2006 | J Clin Invest2006，116，9： | 1 |
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