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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Mechanisms of altered bone remodeling in children with type 1 diabetes显示文摘Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in life.The mechanisms underlying diabetic bone fragility are not yet completely understood.Hyperglycemia and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and microarchitecture.Several factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone turnover.Some myokines may have a key role in regulating metabolic control and improving bone mass in T1DM subjects.The aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM. | Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza | 2021 | World Journal of Diabetes2021，12，7： | 3 |
| 3 | Coronary atherosclerosis and a rare combinination of congenital coronary anomalies in STelevation acute myocardial infarction显示文摘 | Brunetti N D Cuculo A Ruggiero A | 2012 | J Cardiowasc Med(Hagerstown)2012，14，4： | 1 |
| 4 | Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage显示文摘 | FRID M G BRUNETTI J A BURKE D L | 2006 | Am J Pathol2006，168，2： | 1 |
| 5 | Plasticizer for poly(vinylchloride) from cardanol as a renewable resource material显示文摘 | Greco A Brunetti D Renna G | 2010 | Polymer Degradation and Stability2010，95，21： | 1 |
| 6 | Perspectives on the contribution of genetics to the pathogenesis of type 2 diabetes mellitus 显示文摘 | Brunetti A Chiefari E Foti D | 2011 | Recenti Prog Med2011，102，12： | 1 |
| 7 | Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri-and post-menopausal breast cancer显示文摘 | Bonin S Brunetti D Benetti D | 2006 | Virchows Arch2006，448，5： | 1 |
| 8 | Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri-and post-menopausa/ breast cancer显示文摘 | Bonin S Brunetti D Benedetti E | 2006 | Virchows Arch2006，448，5： | 1 |
| 9 | Transgene expression of green fluorescent protein and germ line transmission in cloned pigs derived form in vitro transfected adult fibroblasts 显示文摘 | Brunetti D Perota A Lagutina I | 2008 | Cloning Stem Cells2008，10，4： | 1 |
| 10 | Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor显示文摘 | Brunetti A Goldfine I D | 1990 | J Biol Chem1990，265，： | 1 |
| 11 | Plasticizer for poly (vinyl chloride) from cardanol as a renewable resource material显示文摘 | GRECO A BRUNETTI D RENNA G | 2010 | Polymer Degradation and Stability2010，95，11： | 1 |
| 12 | Therapeutic ap- proaches to myetoma bone disease: an evolving story显示文摘 | Longo V Brunetti O D' Oronzo S | 2012 | Cancer Treat Rev2012，38，6： | 1 |
| 13 | Plasticizer for poly (vinyl chlo- ride) from cardanol as a renewable resource material 显示文摘 | A Greco D Brunetti | 2010 | Polymer Degradation and Stability2010，95，： | 1 |
| 14 | Plasticizer for poly (vinyl chloride) from cardanol as a renewable resource material显示文摘 | Greco A Brunetti D Renna G | 2010 | Polymer Degradation and Stability2010，95，11： | 1 |
| 15 | Role of mycobacteria-induced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis显示文摘 | Bocchino M Galati D Sanduzzi A Colizzi V Brunetti E Mancino G | 2005 | Int J Tuberc Lung Dis2005，9，4： | 1 |
| 16 | Precipitation Concentration Changes in Spain 1946-2005显示文摘 | Luis M D Gonzalez-Hidalgo J C Brunetti M | 2011 | Natural Hazards and Earth System Science2011，11，5： | 1 |
| 17 | Subacute inflammatory activation in subjects with acute coronary syndrome and left ventricular dysfunction 显示文摘 | De Gennaro L Brunetti N D Montrone D | 2012 | Inflammation2012，35，5： | 1 |
| 18 | Bone metastases in hepatoceUular carcinoma:an emerging issue显示文摘 | Longo V Brunetti O D'Oronzo S | 2014 | Cancer Metastasis Rev2014，33，1： | 1 |
| 19 | Carbohydrate antigen-125: additional accuracyin identifying patients at risk of acute heart failure inacute coronary syndrome显示文摘 | DE GENNARO L BRUNETTI N D BUNGARO R | 2009 | Coronary Artery Dis2009，20，4： | 1 |
| 20 | Inflammatory activation and carbohydrate antigen-125 levels in subjects with atrial fibrillation 显示文摘 | De Gennaro L Brunetti ND Montrone D | 2012 | Eur J Clin Invest2012，42，4： | 1 |
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