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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Cloning, expression, purification and characterization of recombinant( + )-germacrene D synthase from Zin- giber officinale 显示文摘 | PICAUD S OLSSON M E BRODELIUS M | 2006 | Arch Biochem Biophys2006，452，1： | 1 |
| 3 | Plant cell culture using a novel bioreactor: The magnetically stabilised fluidized bed显示文摘 | BRAMBLE J L GRAVES D J BRODELIUS | 1990 | Biotechnology Progress1990，6，： | 1 |
| 4 | Permeabilization of immobilized plant cells,resulting in release of intracelluarly stored products with preserved cell viability显示文摘 | Brodelius PE Nilsson K | 1983 | Appl Microl Biotechol1983，17，： | 1 |
| 5 | Permeabilization of plant cells for release of intracellulary products: viability studies显示文摘 | Brodelius PE | 1988 | Appl Microbiol Biotechnol1988，27，： | 1 |
| 6 | Immobilized plant cells for the production and transformation of natural products显示文摘 | Brodelius P Deus B Mosbach K | 1979 | FEBS Lett1979，103，1： | 1 |
| 7 | Immobilised plant cells: respiration and oxygen transfer 显示文摘 | Hulst A C Tramper J Brodelius P | 1985 | Journal of Chemical Technology and Biotechnology1985，35，3： | 1 |
| 8 | Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase,a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum显示文摘 | Lundgren A Brodelius PE | 2002 | Eur J Biochem2002，269，14： | 1 |
| 9 | Plant cell culture using a novel bioreactor:the magnetically stabilized fluidized bed显示文摘 | J L Bramble D J Graves P Brodelius | 1990 | Biotechnol Prog1990，，6： | 1 |
| 10 | Enzyme activities of the primary and secondary metabolism of simultaneously permeabilized and immobilized plant cells显示文摘 | FLIX H BRODELIUS P MOSBACH K | 1981 | Anal Biochem1981，116，2： | 1 |
| 11 | Expression, purification and characterization of recombinant (E) beta-farnesene synthase from Artemisia annua显示文摘 | Picaud S Brodelius M Brodelius P E | 2005 | Phytochemistry2005，66，9： | 1 |
| 12 | Fusion of farnesyldiphosphate synthase and epi-aristoloehene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum 显示文摘 | Brodelius M Lundgren A Mercke P | 2002 | Eur J Biochem2002，269，： | 1 |
| 13 | Enzyme activities of the primary and secondary metabolism of simultaneously permeabilized and immobilized plant cells Catharanthus roseus显示文摘 | Felix H Brodelius P Mosbach K | 1981 | Anal Biochem1981，116，2： | 1 |
| 14 | Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.显示文摘 | Mikael E. Olsson Linda M. Olofsson Ann-Louise Lindahl Anneli Lundgren Maria Brodelius Peter E. Brodelius | 2009 | Phytochemistry2009，，9： | 1 |
| 15 | Immobilized plant cells for the production and transformation of natural products 显示文摘 | Brodelius P Deus B Mosbach K | 1979 | FEBS Lett1979，103，1： | 1 |
| 16 | Calcium and phosphateeffects on growth and alkaloid production in Coffee arabica:Experimental results and mathematical model显示文摘 | Bramble J L Graves D J Brodelius P | 1991 | Biodechnology& Bioengineering1991，37，： | 1 |
| 17 | Induced secondary product formation in plant cell suspension cultures after treatment with a yeast carbohydrate preparation(elicitor) 显示文摘 | Funk C Gugler K Brodelius P | 1987 | Phytochemistry1987，26，2： | 1 |
| 18 | Induced secondary product formation in plant cell suspension cultures after treatment with a yeast carbohydrate preparation (elicitor)显示文摘 | Funk C Gugler K Brodelius P | 1987 | Phytochemistry1987，26，2： | 1 |
| 19 | Increasing secondary metabolite production in plant-cell culture by redirecting transport显示文摘 | Peter Brodelius Henrik Pedersen | 1993 | Trend in Biotech1993，11，1： | 1 |
| 20 | Phenlypropanoid Metabolism In Suspension Cultures of Vanilla Planifolia And Metabolic Inhibitors显示文摘 | Funk C Brodelius P E | 1990 | Plant Physical1990，94，： | 1 |
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