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| 1 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | Modified water regime and salinity as a consequence of climate change: Prospects for wetl rods of Southern Australia 显示文摘 | NIELSEN D L BROCK M A | 2009 | Climatic Change2009，95，34： | 1 |
| 4 | Age-related cataract显示文摘 | Asbell PA Dualan I Mindel J Brocks D Ahmad M Epstein S etal | 2005 | Lancet2005，365，9459： | 1 |
| 5 | Motor, emotional, and cognitive empathy in children and adolescents with autism spectrum disorder and conduct disorder显示文摘 | Bons D vanden Brock E Scheepers F | 2013 | J Abnorm Child Psychol2013，41，3： | 1 |
| 6 | Radiation environment measurements with the comic ray experiments on-board the KITSAT-1 and PoSAT-1 micro-sattellites显示文摘 | Brock D J Williams P S | 1994 | IEEE TransNuclSci1994，41，6： | 1 |
| 7 | Structure, magnetism, and magnetocaloric properties of MnFel ~ P~ com- pounds 显示文摘 | Cam Thanh D T BrOck E Trung N T | 2008 | Appl Phys2008，103，07： | 1 |
| 8 | Bubble nucleation in an explosive micro-bubble actuator显示文摘 | van den Brock D M Elwenspoek M | 2008 | J Micromech Micro- eng2008，18，6： | 1 |
| 9 | Crack extension at an interface: Prediction of fracture toughness and simulation of crack path deviation显示文摘 | NEGRE P STEGLICH D BROCKS W | 2005 | International Journal of Fracture2005，134，34： | 1 |
| 10 | Relationship between Fish Communities and Remotely Sensed Measurements in Bis- cayne National Park, Florida, USA显示文摘 | Kuffner I B Brock J C Grober D R | 2007 | Environmental Biology of Fishes2007，78，1： | 1 |
| 11 | Experience with building a commodity Intel-based eeNUMA system 显示文摘 | Brock B C Carpenter G D Chiprout E | 2001 | IBM J RES & DEV2001，45，2： | 1 |
| 12 | Measurement of soil microbial biomass provides an early indication of changes in total organic matter due to straw incorporation 显示文摘 | Powlson D S Brockes P C Christensen B T | 1987 | Soil Biology &Biochemistry1987，19，： | 1 |
| 13 | A test for independence based on the correlation dimension显示文摘 | Dechert D Scheinkman B | 1996 | Econometric Reviews1996，15，： | 1 |
| 14 | Continuous measurements of cerebral tissue oxygen pressure during hyperbaric oxygenation-HBO effects on brain edema and necrosis after severe brain trauma in rabbits显示文摘 | Niklas A Brock D Schober R | 2004 | J Neurol Sci2004，219，12： | 1 |
| 15 | Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease显示文摘 | BROCK J W HINTON D J COTHAM W E | | 0，，05： | 1 |
| 16 | Prognostic stratification for chil- dren with hepatoblastoma: the SIOPEL experience显示文摘 | Maibach R Roebuck D Brugieres L Capra M Brock P DalPIgna P | 2012 | Eur J Cancer2012，48，： | 1 |
| 17 | Hepatic ablation using radiofrequency electrocautery显示文摘 | mc GAHAN J P BROWNING P D BROCK J M | 1990 | Invest Radiol1990，25，3： | 1 |
| 18 | Effect of temperature on blue-green algae (cyanobacteria) in Lake Mendota 显示文摘 | Konopka A Brock T D | 1978 | Applied and Environmental Microbiology1978，36，： | 1 |
| 19 | Sweating responses during heat acclimation and moderate conditioning显示文摘 | Shvartz E Bhattacharya A Sperinde S J Brock P J Sciaraffa D Van Beaumont W | 1979 | J Appl Physiol1979，46，： | 1 |
| 20 | lntevprofessional educa- tion in tcmn communication: working together to improve pa- tient safety显示文摘 | Brock D Abu-Rish E Chiu CR | 2013 | Postgrad Mcd J2013，89，1057： | 1 |
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