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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | A high-throughput methodology for screening solution-based chelating agents for efficient palladium removal显示文摘 | ERIK F BRIGITTE E SHU Y | 2007 | QSAR & Combinatorial Science2007，26，5： | 1 |
| 3 | Development of an Effective Palladium Removal Process for VEGF Oncology Candidate AG13736 and a Simple,Efficient Screening Technique for Scavenger Reagent Identification显示文摘 | ERIK J F BRIGITTE L E NEAL W S | 2008 | Organic Process Research & Development2008，，12： | 1 |
| 4 | Tablets of Hamamelis Dry Extract by Direct Compression: Comparative Study of Natural Starches and Starch Derivatives显示文摘 | Brigitte Vennat Denis Cross Aimée Pourrat Henri Pourrat | 1993 | Drug Development and Industrial Pharmacy1993，，11： | 1 |
| 5 | How to Implement a Naturalistic Model of Abstracting: Four Core Working Steps of An Expert Abstractor显示文摘 | Brigitte E Elisabeth M Alexander S | 1995 | Informatin Processing & Management1995，31，5： | 1 |
| 6 | Introduction : Automatic Summarizing显示文摘 | Jones K Brigitte E N | 2005 | Infor- mation Processing & Management2005，31，5： | 1 |
| 7 | A coumaroylester-3-hydroxylase insertion mutant reveals the existence of nonredundant meta-hydroxylation pathways and essential roles for phenolic precursors in cell expansion and plant growth显示文摘 | Nawroz A Brigitte P Jtirgen E | 2006 | Plant Physiology2006，140，： | 1 |
| 8 | Expression of hepatocyte growth factor in human hepatocellular carcinoma显示文摘 | Josée Guirouilh Brigitte Le Bail Liliane Boussarie Charles Balabaud Paulette Bioulac-Sage Alexis Desmoulière Detlef Schuppan Jean Rosenbaum | 2001 | Journal of Hepatology2001，，1： | 1 |
| 9 | Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells显示文摘 | Amber-p Barnes Brigitte E Miller Gregory | 2007 | Gynecol Oncol2007，104，2： | 1 |
| 10 | Increased activity of the diastrophic dyaplasia sulfate transporter in otosclerosis and its inhibition by sodium fluoride显示文摘 | Alexis BG Brigitte E Maurice B | 2003 | Otology & Neurotology2003，24，： | 1 |
| 11 | Detection,isolation and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)显示文摘 | YING H G BRIGITTE G DONNA E H | 2003 | Blood2003，101，8： | 1 |
| 12 | Development of an effective palladium removal process for VEGF oncology candidate AG13736 and a simple,efficient screening technique for scavenger reagent identification显示文摘 | ERIK J F BRIGITTE L E NEAL W S | 2008 | Org Process Res Dev2008，12，： | 1 |
| 13 | Sealing system selection for jointed concrete pavernent-a review显示文摘 | Brigitte O E Nii A O | 2006 | Construction and Building Materials2006，20，8： | 1 |
| 14 | Signaling by death receptors in the nervous system显示文摘 | Georg Haase Brigitte Pettmann Cédric Raoul Christopher E Henderson | 2008 | Current Opinion in Neurobiology2008，，3： | 1 |
| 15 | Detoxification Yang Fang clinical observation on the treatment oftype 2 diabetes mellitus显示文摘 | Brigitte M Silke E | 2014 | Modern J Integrat Trad Chin Western Med2014，23，7： | 1 |
| 16 | Fixed fees and physician-induced demand: A panel data study on French physicians显示文摘 | Delattre E Brigitte D | 2003 | Heahh Economics2003，12，9： | 1 |
| 17 | Fixed fees and physician induced demand: A panel data study on French physicians显示文摘 | Delattre E Brigitte Dormont | 2003 | Health Economics2003，，12： | 1 |
| 18 | A review of the time management literature显示文摘 | Brigitte JCC Wendelien van E Christel GR | 2007 | Pers Rev2007，36，2： | 1 |
| 19 | Biosynthesis and incorporation of side-chain-truncatedlignin monomers to reduce lignin polymerization and enhance sac-charification显示文摘 | AYMERICK E ANTHE G PURBA M JIN S K BRIGITTE P PETER I B | 2012 | Plant Biotechnolgoy Journal2012，10，： | 1 |
| 20 | Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial显示文摘 | Aimée HMM Arits Klara Mosterd Brigitte AB Essers Eefje Spoorenberg Anja Sommer Michette JM De Rooij Han PA van Pelt Patricia JF Quaedvlieg Gertruud AM Krekels Pierre AFA van Neer Joris J Rijzewijk Adrienne J van Geest Peter M Steijlen Patty J Nelemans Nic | 2013 | Lancet Oncology2013，，7： | 1 |
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