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| 1 | Paediatric and adult colonic manometry: A tool to help unravel the pathophysiology of constipation显示文摘Colonic motility subserves large bowel functions, including absorption, storage, propulsion and defaecation. Co-lonic motor dysfunction remains the leading hypothesis to explain symptom generation in chronic constipation, a heterogeneous condition which is extremely prevalent in the general population, and has huge socioeconomic impact and individual suffering. Physiological testing plays a crucial role in patient management, as it is now accepted that symptom-based assessment, although im-portant, is unsatisfactory as the sole means of directing therapy. Colonic manometry provides a direct method for studying motor activities of the large bowel, and this review provides a contemporary understanding of how this technique has enhanced our knowledge of normalcolonic motor physiology, as well as helping to elucidate pathophysiological mechanisms underlying constipation. Methodological approaches, including available catheter types, placement technique and recording protocols, are covered, along with a detailed description of re-corded colonic motor activities. This review also criti-cally examines the role of colonic manometry in current clinical practice, and how manometric assessment may aid diagnosis, classification and guide therapeutic inter-vention in the constipated individual. Most importantly, this review considers both adult and paediatric patients. Limitations of the procedure and a look to the future are also addressed. | Philip G Dinning Marc A Benninga Bridget R Southwell S Mark Scott | 2010 | World Journal of Gastroenterology2010，16，41： | 1 |
| 2 | Cadmium,Lead,and Other Metals in Relation to Semen Quality:Human Evidence forMolybdenum as a Male Reproductive Toxicant显示文摘 | John D M Mary G R Bridget P | 2008 | Environ Health Perspect2008，116，11： | 1 |
| 3 | The effect of various stresses, corticosteroids and adrenergic agents on phagocytosis in the rainbowtrout Oncorhynchus mykiss 显示文摘 | Narnaware Yuwaraj K Baker I Bridget TomLinson G Mike | 1994 | Fish Physiology and Biochemistry1994，13，1： | 1 |
| 4 | Chemokine receptor inhibitor by AMD3100 is strictly confined to CXCR4显示文摘 | Hatse S Princan K Bridget G | 2002 | FEBS Lett2002，527，： | 1 |
| 5 | Both actin and polypro- line interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothe- lial cells 显示文摘 | Zhijie D David G Bridget D | 2009 | Experimental Cell Research2009，315，17： | 1 |
| 6 | A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa 显示文摘 | Andrew L G Bridget K Arne R | 2004 | Developmental Cell2004，7，： | 1 |
| 7 | CXCR4 in clinical hematology 显示文摘 | Calandra G Bridget G Fricker S | 2010 | Curr Top Microbiol Immunol2010，341，： | 1 |
| 8 | Choosing appropriate techniques for quantifying groundwater recharge显示文摘 | BRIDGET R S HEALY R W COOK P G | 2002 | Hydrogeology Journa12002，10，1： | 1 |
| 9 | Choosing ap-propriate tech-niques for quantifying groundwater recharge 显示文摘 | Bridget R Scanlon Healy R W Cook P G | 2002 | Hydrogeology Journal2002，10，1： | 1 |
| 10 | Cadmium,Lead,and other metals in relation to semen quality:Human evidence for molybdenum as a male reproductive toxicant显示文摘 | John D M Mary G R Bridget P | 2008 | Environmental Health Perspectives2008，116，11： | 1 |
| 11 | The conditional probability of survival of patients with primary malignant brain tumors:surveillance, epidemiolgy, and end results(SEER) data显示文摘 | Faith G D Bridget J M Sally F | 1999 | Cancer1999，85，2： | 1 |
| 12 | Ontogeny of the digestive and feeding systems in the anemonefish Amphiprion melanopus显示文摘 | Bridget S G Mark M I | 2001 | Environmental Biology of Fishes2001，61，： | 1 |
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