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| 1 | Late complications of pancreas transplant显示文摘To summarize the long-term complications after pancreas transplantation that affect graft function,a literature search was carried out on the long-term complications of pancreatic transplantation,namely,complications from postoperative 3rd mo onwards,in terms of loss of graft function,late infection and vascular complications as pseudoaneurysms.The most relevant reviews and studies were selected to obtain the current evidence on these topics.The definition of graft failure varies among different studies,so it is difficult to evaluate,a standardized definition is of utmost importance to know the magnitude of the problem in all worldwide series.Chronic rejection is the main cause of long-term graft failure,occurring in 10%of patients.From the 3rd mo of transplantation onwards,the main risk factor for late infections is immunosuppression,and patients have opportunistic infections like:Cytomegalovirus,hepatitis B and C viruses,Epstein-Barr virus and varicella-zoster virus;opportunistic bacteria,reactivation of latent infections as tuberculosis or fungal infections.Complete preoperative studies and serological tests should be made in all recipients to avoid these infections,adding perioperative prophylactic treatments when indicated.Pseudoaneurysm are uncommon,but one of the main causes of late bleeding,which can be fatal.The treatment should be performed with radiological endovascular approaches or open surgery in case of failure.Despite all therapeutic options for the complications mentioned above,transplantectomy is a necessary option in approximately 50%of relaparotomies,especially in lifethreatening complications.Late complications in pancreatic transplantation threatens long-term graft function.An exhaustive follow-up as well as a correct immunosuppression protocol are necessary for prevention. | Javier Maupoey Ibáñez Andrea BoscàRobledo Rafael López-Andujar | 2020 | World Journal of Transplantation2020，10，12： | 2 |
| 2 | Urea as a marker of adequacy in hemodialysis : Lesson from in vivo urea dynamics monitoring显示文摘 | Canaud B Bosc JY Cabrol L | 2000 | Kidney Int2000，58，： | 1 |
| 3 | TiO2 anatase-based membranes with hierarchical porosity and photocatalytic properties 显示文摘 | Bosc F Patrick L D | 2006 | Journal of Colloid and Interface Science2006，304，54： | 1 |
| 4 | Labdanediterpenes protect against anoxia/reperfusion injury in cardiomyocytes:involvement of AKT activation显示文摘 | Cuadrado I Fernández-Velasco M Boscá L | | 0，，02： | 1 |
| 5 | Asthma and pulmonaryarterial hypertension:do they share a key mechanism of patho- genesis? 显示文摘 | Said SI Hamidi SA Gonzalez Bosc L | 2010 | Eur Respir J2010，35，4： | 1 |
| 6 | Pro- staglandin E2 promotes migration and adhesion in hepa- tocellular carcinoma cells 显示文摘 | Mayoral R Fernendez-Martenez A Bosce L | 2005 | Carcinogenesis2005，26，4： | 1 |
| 7 | Antitumor activity of semisynthetic derivatives of Aconitum alkaloids显示文摘 | Chodoeva A Bosc J J Lartigue L | 2014 | Invest New Drugs2014，32，1： | 1 |
| 8 | Mechanisms of inter- mittent hypoxia induced hypertension显示文摘 | Bosc L V Resta T Walker B | 2010 | J Cell Mol Med2010，14，12： | 1 |
| 9 | Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases显示文摘 | FERNNDEZ-VELASCO M GONZLEZ-RAMOS S BOSCL | 2014 | Biochem J2014，458，2： | 1 |
| 10 | From conventional two-stage hepatectomy to ALPPS:Fifteen years of experience in a hepatobiliary surgery unit显示文摘Background:Hepatectomy in patients with large tumor load may result in postoperative liver failure and associated complications due to excessive liver parenchyma removal.Conventional two-stage hepatectomy(TSH)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique are possible solutions to this problem.Colorectal liver metastases(CRLM)is the most frequent indication,and there is a need to assess outcomes for both techniques to improve surgical and long-term oncological outcomes in these patients.Methods:A single-center retrospective study was designed to compare TSH with ALPPS in patients with initially unresectable bilateral liver tumors between January 2005 and January 2020.ALPPS was performed from January 2012 onwards as the technique of choice.Long-term overall survival(OS)and disease-free survival(DFS)were evaluated as primary outcome in CRLM patients.Postoperative morbidity,mortality and liver growth in all patients were also evaluated.Results:A total of 38 staged hepatectomies were performed:17 TSH and 21 ALPPS.Complete resection rate was 76.5%(n=13)in the TSH group and 85.7%(n=18)in the ALPPS group(P=0.426).Overall major morbidity(Clavien-Dindo≥3 a)(stage 1+stage 2)was 41.2%(n=7)in TSH and 33.3%(n=7)in ALPPS patients(P=0.389),and perioperative 90-day mortalities were 11.8%(n=2)vs.19.0%(n=4)in each group,respectively(P=0.654).Intention-to-treat OS rates at 1 and 5 years in CRLM patients for TSH(n=15)were 80%and 33%,and for ALPPS(n=17)76%and 35%,respectively.DFS rates at 1 and 5 years were 36%and 27%in the TSH group vs.33%and 27%in the ALPPS group,respectively.Conclusions:ALPPS is an effective alternative to TSH in bilateral affecting liver tumors,allowing higher resection rate,but patients must be carefully selected.In CRLM patients similar long-term OS and DFS can be achieved with both techniques. | Javier Maupoey Ibáñez Eva María MontalváOrón Andrea BoscàRobledo Alonso Camacho Ramírez Ana Hernando Sanz Pablo Granero Castro Alberto Alegre Delgado Rafael López-Andújar | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，6： | 0 |
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