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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | The innate immune response to allotransplants: mechanisms and therapeutic potentials显示文摘Surgical trauma and ischemia reperfusion injury(IRI)are unavoidable aspects of any solid organ transplant procedure.They trigger a multifactorial antigen-independent inflammatory process that profoundly affects both the early and long-term outcomes of the transplanted organ.The injury associated with donor organ procurement,storage,and engraftment triggers innate immune activation that inevitably results in cell death,which may occur in many different forms.Dying cells in donor grafts release damage-associated molecular patterns(DAMPs),which alert recipient innate cells,including macrophages and dendritic cells(DCs),through the activation of the complement cascade and toll-like receptors(TLRs).The long-term effect of inflammation on innate immune cells is associated with changes in cellular metabolism that skew the cells towards aerobic glycolysis,resulting in innate immune cell activation and inflammatory cytokine production.The different roles of proinflammatory cytokines in innate immune activation have been described,and these cytokines also stimulate optimal T-cell expansion during allograft rejection.Therefore,early innate immune events after organ transplantation determine the fate of the adaptive immune response.In this review,we summarize the contributions of innate immunity to allograft rejection and discuss recent studies and emerging concepts in the targeted delivery of therapeutics to modulate the innate immune system to enhance allograft survival. | Jordi Ochando Farideh Ordikhani Peter Boros Stefan Jordan | 2019 | Cellular & Molecular Immunology2019，16，4： | 5 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis显示文摘BACKGROUND Despite the improvement in the endoscopic hemostasis of non-variceal upper gastrointestinal bleeding(NVUGIB),rebleeding remains a major concern.AIM To assess the role of prophylactic transcatheter arterial embolization(PTAE)added to successful hemostatic treatment among NVUGIB patients.METHODS We searched three databases from inception through October 19th,2020.Randomized controlled trials(RCTs)and observational cohort studies were eligible.Studies compared patients with NVUGIB receiving PTAE to those who did not get PTAE.Investigated outcomes were rebleeding,mortality,reintervention,need for surgery and transfusion,length of hospital(LOH),and intensive care unit(ICU)stay.In the quantitative synthesis,odds ratios(ORs)and weighted mean differences(WMDs)were calculated with the random-effects model and interpreted with 95%confidence intervals(CIs).RESULTS We included a total of 3 RCTs and 9 observational studies with a total of 1329 patients,with 486 in the intervention group.PTAE was associated with lower odds of rebleeding(OR=0.48,95%CI:0.29–0.78).There was no difference in the 30-d mortality rates(OR=0.82,95%CI:0.39–1.72)between the PTAE and control groups.Patients who underwent PTAE treatment had a lower chance for reintervention(OR=0.48,95%CI:0.31–0.76)or rescue surgery(OR=0.35,95%CI:0.14–0.92).The LOH and ICU stay was shorter in the PTAE group,but the difference was non-significant[WMD=-3.77,95%CI:(-8.00)–0.45;WMD=-1.33,95%CI:(-2.84)–0.18,respectively].CONCLUSION PTAE is associated with lower odds of rebleeding and any reintervention in NVUGIB.However,further RCTs are needed to have a higher level of evidence. | Eszter Boros Zoltán Sipos Péter Hegyi Brigitta Teutsch Levente Frim Szilárd Váncsa Szabolcs Kiss FanniDembrovszky Eduard Oštarijaš Andrew Shawyer Bálint Erőss | 2021 | World Journal of Gastroenterology2021，27，40： | 2 |
| 5 | The COVID-19 pandemic and physical activity显示文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article. | Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji | 2020 | Sports Medicine and Health Science2020，2，2： | 2 |
| 6 | Th2 cells are re- quired for the Schistosoma mansoni egg induced granulomatous re- sponses显示文摘 | Kaplan M H Whitefield J R Boros D L | 1998 | J Immunol1998，160，4： | 1 |
| 7 | Detection of resistance to imatinib by metabolic pro- filing: clinical and drug development im- plications 显示文摘 | Serkova N Boros LG | 2005 | Am J Pharmacogenomics2005，5，5： | 1 |
| 8 | Improving software reliability forecasting 显示文摘 | Butschy B Albeanu G Boros D N | 1997 | Microelectronies and Reliability1997，37，6： | 1 |
| 9 | Identification of larval cross-reaction and egg-specific antigens involved in granuloma formation in murine schistomomiasis mansoni显示文摘 | Lukacs NW Boros DL | | 0，，09： | 1 |
| 10 | Endothelin 1 induces leukocyte adhesion in submucosal venules of the rat small Intestine显示文摘 | Boros M Massberg S Baranyi L | 1998 | Gastroenterology1998，114，1： | 1 |
| 11 | Iridoids, an updated review显示文摘 | Boros CA Stermitz FR | 1990 | J Nat Prod1990，53，5： | 1 |
| 12 | Methane formation in aerobic environments显示文摘 | Keppler F Boros M Frankenberg C | 2009 | Environmental Chemistry2009，6，6： | 1 |
| 13 | Fas ligand-expressing B-la lymphoeytes mediate CD4 (--)-T-cell apoptosis during schistosomal infec tion induction by interleukin 4 (IL-4) and IL-10显示文摘 | Lundy SK Boros DL | 2002 | Infect Im- mun2002，70，2： | 1 |
| 14 | Tumor necrosis factor play a role in schistosoma mansoni egg-induced granulomatous inflammation显示文摘 | Joseph AL Boros DL | 1993 | The Journal of Immunology1993，151，10： | 1 |
| 15 | Plasma fractionation : production and properties of albu- min显示文摘 | Boros B | 1979 | Ann ImmunolHung1979，19，： | 1 |
| 16 | Phase II study of ifosfamide,carboplatin,and etoposide in patients with advanced non- small cell lung cancer 显示文摘 | Hsieh RK Chang AY Boros L | 1994 | Am J Clin Oncol1994，17，6： | 1 |
| 17 | Inhibition of the oxidative and nonoxidative pentose phosphate pathways by somatostatin:a possible mechanism of antitumor action显示文摘 | Boros LG Brandes JL Yusuf FI | 1998 | Med Hypotheses1998，50，6： | 1 |
| 18 | Tumor necrosis factor plays a role in Schistosoma mansoni egg- induced granulomatous inflammation 显示文摘 | Joseph AL and Boros DL | 1993 | J Immunol1993，151，10： | 1 |
| 19 | New cellular and molecular immune pathways in ischemia/reperfusion injury显示文摘 | Boros P Bromberg JS | 2006 | Am J Transplant2006，6，4： | 1 |
| 20 | Intrabepatic expression and release of vascular endothelial growth factor following orthotopic liver transplantation in the rat显示文摘 | Boros P TaresafalviA Wang L | 2001 | Transplantation2001，72，： | 1 |
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