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| 1 | Structural insights into NEDD8 activation of cnllin-RING ligases: confor- mational control of conjugation 显示文摘 | Duda DM Borg LA Scott DC | 2008 | Cell2008，134，6： | 1 |
| 2 | Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats 显示文摘 | Reis LA Borges IT Simoes MJ | 2012 | PLoS One2012，7，44： | 1 |
| 3 | Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro显示文摘 | Carlsson C Borg LA Welsh N | 1999 | Endocrinoogyl1999，140，8： | 1 |
| 4 | Focus on vitamin D, inflammation and type 2 diabetes显示文摘 | Chagas CEA Borges MC Martini LA | 2012 | Nutrients2012，4，1： | 1 |
| 5 | A comparison of molar root canal preparation using stainless-steel and nickel-titanium instruments显示文摘 | Carvalho LA Bonetti I Borges MA | 1999 | J Endod1999，25，12： | 1 |
| 6 | Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain显示文摘 | Favero-Filho LA Borges AA Grassl C | 2008 | Braz J Med Biol Res2008，41，11： | 1 |
| 7 | Current perspertives on Vitamin D, immune system, and chronic diseases 显示文摘 | Borges MC Martini LA Rogero MM | 2011 | Nutri- tion2011，27，4： | 1 |
| 8 | An iterative algorithm for limit analysis with nonlinear yield functions显示文摘 | OUAIN N HERSKOVITS J BORGES LA | 1993 | International Journal of Solids and Structures1993，30，10： | 1 |
| 9 | Ex'tracellular vesicles: structure, function, and potential clinical uses in renal diseases显示文摘 | Borges FT Reis LA Schor N | 2013 | Braz J Med Biol Res2013，46，10： | 1 |
| 10 | Focus on vitamin D, inflammation and type 2 diabetes显示文摘 | Chagas CE Borges MC Martini LA | 2012 | Nutrients2012，4，1： | 1 |
| 11 | FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer显示文摘AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.METHODS This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and safety.RESULTS Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the 'irinotecan-na?ve' patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the 'pre-exposed irinotecan' patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), respectively.CONCLUSION Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept. | CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel | 2018 | World Journal of Clinical Oncology2018，9，5： | 1 |
| 12 | Occupational exposures to body fluids and behaviors regarding their prevention and postexposure among medical and nursing students at a Brazilian public university显示文摘 | SouzaBorges FR Ribeiro LA Oliveira LC | 2014 | Rev Inst Med Trop Sao Paulo2014，56，2： | 1 |
| 13 | Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro显示文摘 | Carlsson C Borg LA Welsh N | 1999 | Endocrinology1999，140，： | 1 |
| 14 | Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of-focal ischemia in the rat brain显示文摘 | Favero-Filho1 LA Borges AA Grassl C | 2008 | Brazilian Journal of Medical and Biological Research2008，41，： | 1 |
| 15 | Hyoerthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain显示文摘 | Favero-Filho LA Borges AA Grassl C | 2008 | Braz J Med Biol Res2008，41，11： | 1 |
| 16 | Protection by free oxygen radical scavenging enzymes against glucose induced embryonic malformations in vitro 显示文摘 | Eriksson U J Borg LA | 1991 | Diabetologia1991，34，5： | 1 |
| 17 | Current perspectives onvita- rain D, immune system, and chronic diseases 显示文摘 | Borges MC Martini LA Rogero MM | 2011 | Nutrition2011，27，4： | 1 |
| 18 | Focus on vitamin D, inflammation and type 2 diabetes显示文摘 | Chagas CE Borges MC Martini LA | 2012 | Nutrients2012，4，1： | 1 |
| 19 | Focus on vitamin D, inflammation and type2 diabetes显示文摘 | Chagas CE Borges MC Martini LA | 2012 | Nutrients2012，4，1： | 1 |
| 20 | Extracellular vesicles: structure, function, and potential clinical uses in renal diseases显示文摘 | Borges FT Reis LA Schor N | 2013 | Braz J Med Biol Res2013，46，10： | 1 |
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