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| 1 | Fast-tracking regenerative medicine for traumatic brain injury显示文摘Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death.Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect.In this review,we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation,edema,and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants.Although these studies of stand-alone treatments have yielded some positive results,more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy.Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts.The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan | 2020 | Neural Regeneration Research2020，15，7： | 5 |
| 2 | Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy显示文摘Stroke persists as a global health and economic crisis,yet only two interventions to reduce stroke-induced brain injury exist.In the clinic,many patients who experience an ischemic stroke often further suffer from retinal ischemia,which can inhibit their ability to make a functional recovery and may diminish their overall quality of life.Despite this,no treatments for retinal ischemia have been developed.In both cases,ischemia-induced mitochondrial dysfunction initiates a cell loss cascade and inhibits endogenous brain repair.Stem cells have the ability to transfer healthy and functional mitochondria not only ischemic neurons,but also to similarly endangered retinal cells,replacing their defective mitochondria and thereby reducing cell death.In this review,we encapsulate and assess the relationship between cerebral and retinal ischemia,recent preclinical advancements made using in vitro and in vivo retinal ischemia models,the role of mitochondrial dysfunction in retinal ischemia pathology,and the therapeutic potential of stem cell-mediated mitochondrial transfer.Furthermore,we discuss the pitfalls in classic rodent functional assessments and the potential advantages of laser Doppler as a metric of stroke progression.The studies evaluated in this review highlight stem cell-derived mitochondrial transfer as a novel therapeutic approach to both retinal ischemia and stroke.Furthermore,we posit the immense correlation between cerebral and retinal ischemia as an underserved area of study,warranting exploration with the aim of these treating injuries together. | Chase Kingsbury Matt Heyck Brooke Bonsack Jea-Young Lee Cesar V.Borlongan | 2020 | Neural Regeneration Research2020，15，6： | 2 |
| 3 | Abdominal adhesions to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I | | 0，，02： | 1 |
| 4 | Visceral adhesions to hernia prostheses显示文摘 | Gaertner WB Bonsack ME Delaney JP | 2010 | Hernia2010，14，4： | 1 |
| 5 | Abdominal ad- hesions to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I | 2000 | J Am Coil Surg2000，190，3： | 1 |
| 6 | Abdominal adhesions to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I etal | 2000 | J Am Coll Surg2000，190，3： | 1 |
| 7 | Radioprotection of the rat small intestine with topical WR-2721 显示文摘 | Delaney JP Bonsack ME Felemovicius I | 1994 | Cancer1994，74，8： | 1 |
| 8 | Abdominal adhesions to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I | 2000 | Am Coll Surg2000，190，2： | 1 |
| 9 | Abdominal adhesions to prosthetic mesh evaluated by laparoscopy and electron microscopy 显示文摘 | Baptista ML Bonsack ME Felemovicius I | 2000 | J Am Coll Surg2000，190，3： | 1 |
| 10 | Abdominal adhesions to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I | 2000 | J Am Coll Surg2000，190，： | 1 |
| 11 | Atypical antipsychotics and sexual dysfunction : five case-reports associated with risperidone显示文摘 | Haefliger T Bonsack C | 2006 | Eneephale2006，32，1： | 1 |
| 12 | Seprafilm reduces adhesions to polypropylene mesh显示文摘 | Baptista ML Bonsack ME Delaney JP | 2000 | Surgery2000，128，1： | 1 |
| 13 | Abdominal adhension to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I | 2000 | Surgery2000，128，1： | 1 |
| 14 | Abdominal adhension to prosthetic mesh evaluated by laparoscopy and electron microscopy显示文摘 | Baptista ML Bonsack ME Felemovicius I | 2000 | J Am Coll Surg2000，190，： | 1 |
| 15 | Abdominal radiation causes bacterial translocation显示文摘 | GUZMAN G BONSACK M LIBERTY J | 1989 | J Surg Res1989，46，： | 1 |
| 16 | Abdominal radiation causes bacterial translocation 显示文摘 | Guzman GS Bonsack M Liberty J | 1959 | J Surg Res1959，46，2： | 1 |
| 17 | The French Version of the Defense Style Questionnaire 显示文摘 | Despland JN Spagnoli J | 1998 | Psychother Psychosom1998，67，1： | 1 |
| 18 | Abdominal radia- tion causes bacterial translocation 显示文摘 | Guzman-Stein G Bonsack M Liberty J | 1989 | J Surg Res1989，46，2： | 1 |
| 19 | Difficult-to-engage pa- tients: a specific target for time-limited assertive outreach in a Swiss setting 显示文摘 | Bonsack C Adam L Haefliger T | 2005 | Can J Psychiatry2005，50，13： | 1 |
| 20 | Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone显示文摘 | Haefliger T Bonsack C | 2006 | Encephale2006，32，1： | 1 |
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