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| 1 | Osteoporosis in primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an autoimmune cholestatic liver disease with multiple debilitating complications. Osteoporosis is a common complication of PBC resulting in frequent fractures and leading to significant morbidity in this population, yet evidence for effective therapy is lacking. We sought to summarize our current understanding of the pathophysiology of osteoporosis in PBC, as well as current and emerging therapies in order to guide future research directions. A complete search with a comprehensive literature review was performed with studies from Pub Med, EMBASE, Web of Science, Cochrane database, and the Countway Library. Osteoporosis in PBC is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Despite this fundamental difference, current treatment recommendations are based primarily on experience with postmenopausal osteoporosis. Trials specific to PBC-related osteoporosis are small and have not consistently demonstrated a benefit in this population. As it stands, prevention of osteoporosis in PBC relies on the mitigation of risk factors such as smoking and alcohol use, as well as encouraging a healthy diet and weight-bearing exercise. The primary medical intervention for the treatment of osteoporosis in PBC remains bisphosphonates though a benefit in terms of fracture reduction has never been shown. This review outlines what is known regarding the pathogenesis of bone disease in PBC and summarizes current and emerging therapies. | Christopher J Danford Hirsh D Trivedi Konstantinos Papamichael Elliot B Tapper Alan Bonder | 2018 | World Journal of Gastroenterology2018，24，31： | 13 |
| 2 | Hagen-Poiseuille's law:The link between cirrhosis,liver stiffness,portal hypertension and hepatic decompensation显示文摘The onset of hepatic decompensation in cirrhosis heralds an accelerated downhill course with poor outcome. The sole predictor of this decompensationin cirrhosis is increased hepatic vein to portal vein gradient hepatic venous pressure gradient(HVPG). Surrogate markers of liver function or hepatic reserve appear to be less relevant. The hepatic sinusoids become less elastic and more rigid as liver fibrosis and cirrhosis progress. We propose that the HagenPoiseuille's law,which applies to rigid,but not elastic vessels,determines the pressure-flow characteristics in the sinusoids. In the rigid cirrhotic liver,HVPG rises dramatically with any change in net surface area or radius,r4 of the vasculature that follows surgical resection. This review relates liver stiffness to the risk of decompensation in patients with cirrhosis. The liver has a unique dual blood supply comprising a low pressure portal vein and high pressure hepatic artery. We compare the complexity of autoregulation in the normal elastic liver with that in the rigid cirrhotic liver. Therapeutic modalities to reduce portal pressure may reduce the risk of hepatic decompensation and improve outcomes in cirrhosis. | Gerond Lake-Bakaar Muneeb Ahmed Amy Evenson Alan Bonder Salomao Faintuch Vinay Sundaram | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 3 | Effective use of FibroTest to generate decision trees in hepatitis C显示文摘AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy.The FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the target.For testing,a 10-fold cross validation was used.RESULTS:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on F3.The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients.The rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were tested.CONCLUSION:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression. | Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-Reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara Corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz David Kershenobich | 2009 | World Journal of Gastroenterology2009，15，21： | 2 |
| 4 | Intravaginal and intrarectal screening of antimitotic drugs for topical effectiveness 显示文摘 | Van Scott E J Bonder RH | 1971 | J Invest Dermatol1971，56，2： | 1 |
| 5 | Intervaginal and intrarectal screening of antimitotic druugs for topical effectiveness显示文摘 | Van Scott EJ Bonder RH | 1971 | Invest Dermatol1971，56，： | 1 |
| 6 | Acctylsalicylic acidis compounding to antiplaielet effect of C-reactive protein 显示文摘 | Bonder M LuzakB Rozalski M etal | 2007 | Thromb Res2007，119，2： | 1 |
| 7 | Methotrexate in patients with primary biliary cirrhosis who respond incompletely to treatment with ursodeoxycholic acid显示文摘 | Kaplan MM Bonder A Ruthazer R | 2010 | Dig Dis Sci2010，55，11： | 1 |
| 8 | Expression of p16 protein in patient with uterine smooth muscle tumors:an immunohistochemical analysis显示文摘 | Bodner-Adler B Bonder K Czerwenka K | 2005 | Gynecol Oncol2005，96，1： | 1 |
| 9 | Over-expression of sphingosinekinase-1 enhances a progenitor phenotype in humanendothelial cells显示文摘 | Barrett Jeffrey M Parham Kate A Pippal Jyotsna B CockshellMichaelia P Moretti Paul A B Brice Sarah L Pitson StuartM Bonder Claudine S | 2011 | Microcirculation2011，187，： | 1 |
| 10 | Bioinspired design and assembly of platelet reinforced polymer fihns 显示文摘 | BONDERER L J STUDART A R GAUCKLER L J | 2008 | Science2008，319，5866： | 1 |
| 11 | Intravaginal and intrarectal screening of antimitotic drugs for topical effectiveness显示文摘 | Bonder R H | 1971 | J Invest Dermatol1971，56，： | 1 |
| 12 | Methotrexate in patients with primary biliary cirrhosis who respond incompletely to treatment with ursodeoxycholic acid显示文摘 | Kaplan MM Bonder A Ruthazer R | 2010 | Dig Dis Sci2010，55，： | 1 |
| 13 | Bioinspired design and assembly of platelet reinforced polymer films 显示文摘 | BONDERER L J STUDART A R GAUCKLET L J | 2008 | Science2008，，319： | 1 |
| 14 | Interactions of transforming growth factor-β and Ang Ⅱ in renal fibrosis显示文摘 | Bonder WA Noble NA | 1998 | Hypertension1998，31，2： | 1 |
| 15 | Prevalence ofprimary biliary cirrhosis-autoimmune hepatitis overlap syndrome 显示文摘 | BONDER A RETANA A WINSTON D M | 2011 | Clin Gastroenterol Hepatol2011，9，7： | 1 |
| 16 | The GM – CSF / IL‐3 / IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling显示文摘 | Sophie E. Broughton Urmi Dhagat Timothy R. Hercus Tracy L. Nero Michele A. Grimbaldeston Claudine S. Bonder Angel F. Lopez Michael W. Parker | 2012 | Immunol Rev2012，，1： | 1 |
| 17 | Interactions of trnsforming growth factor-βand AngⅡin renal fibrosis显示文摘 | BONDER WA NOBLE NA | 1998 | Hypertension1998，31，： | 1 |
| 18 | Bulk SmCo5/α-Fe composite by plasma pressure consolidation显示文摘 | ZENG Q ZHANG Y BONDER M J | 2003 | IEEE Trans on Magn2003，39，： | 1 |
| 19 | Existence Results for Hamiltonian Elliptic Systems with Nonlinear Boundary Conditions 显示文摘 | BONDER J F PINASCO J P ROSSI J D | 1999 | Electron J Differential Equations1999，1999，40： | 1 |
| 20 | A fourth order elliptic equation with nonlinear boundary conditions显示文摘 | Bonder J Rossi J | 2002 | Nonlinear Anal2002，49，： | 1 |
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