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| 1 | Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice显示文摘 | Pierkes M Gambaryan S Boknik P | 2002 | Cardiovasc Res2002，53，4： | 1 |
| 2 | Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation显示文摘 | El-Armouche A Boknik P Eschenhagen T | 2006 | Circulation2006，114，7： | 1 |
| 3 | Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation显示文摘 | El-Armouche A Boknik P Eschenhagen T | 2006 | Circulation2006，114，7： | 1 |
| 4 | L-type Ca2+ current down-regulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases显示文摘 | Christ T Boknik P Wohrl S | 2004 | Circulation2004，110，： | 1 |
| 5 | Mechanisms of the contractile effects of levosimendan in the mammalian heart显示文摘 | Boknik P Neumann J Kaspareit G | 1997 | J Pharmacol Ea''p Ther1997，280，1： | 1 |
| 6 | Cantharidin enhances norepinephrine- induced vasoconstriction in an endothelium - dependent fashionl 显示文摘 | Knapp J Boknik P Linek B | 2000 | J Pharmacol Exp Ther2000，294，2： | 1 |
| 7 | Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia显示文摘AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+. | Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 8 | L-type Ca2 + current down regula- tion in chronic human atrial fibrillation is associated with increased ac- tivity of protein phosphatases 显示文摘 | Christ T Boknik P Wohrl S | 2004 | Circulation2004，110，17： | 1 |
| 9 | L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases显示文摘 | Christ T Boknik P Wohrl S | 2004 | Circulation2004，110，17： | 1 |
| 10 | L-type Ca^2+ current down regulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases显示文摘 | T Christ P Boknik S W hrl E | 2004 | Circulation2004，110，： | 1 |
| 11 | L-type Ca2+ current downregula- tion in chronic human atrial fibrillation is associated with increased activity of protein phosphatases 显示文摘 | Christ T Boknik P Whrl S | 2004 | Circulation2004，110，17： | 1 |
| 12 | Enhanced protein phosphorylation in hypertensive hypertrophy显示文摘 | Boknik P Heinroth-Hoffmann I Kirchhefer U | 2001 | Cardiovasc Res2001，51，4： | 1 |
| 13 | L-type Ca2+ current down- regulation in chronic human al fibrillation is associated with increased activity of protein phosphatases 显示文摘 | Christ T Boknik P W6hrl S | 2004 | Circulation2004，110，17： | 1 |
| 14 | Molecular deter- minants of altered Ca2 + handling in human ehronie atrial fibrilla- tion显示文摘 | Armouehe A Boknik P Esehenhagen T | 2006 | Circulation2006，15，7： | 1 |
| 15 | L-type Ca2 + current downregulation in chronic human atrial fi- brillation is associated with increased activity of pro- tein phosphatases 显示文摘 | CHRIST T BOKNIK P WOHRL S | 2004 | Circulation2004，110，17： | 1 |
| 16 | L-type Ca^2+ current downregulation in chronic human atral fibrillation is associated with incressed activity of protein phosphatases显示文摘 | Christ T Boknik P Wohrl S | 2004 | Circulation2004，110，17： | 1 |
| 17 | Hemin,inducer of heme-oxygenase 1,improves functional recovery from myocardial stunning in conscious dogs显示文摘 | Weber TP Meissner A Boknik P | | 0，，04： | 1 |
| 18 | Contractility and inhibition of protein phosphatases by cantharidin 显示文摘 | Knapp J Boknik P Huke S | 1998 | Gen Pharmacol1998，31，5： | 1 |
| 19 | L-type Ca2 + current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases显示文摘 | Christ T Boknik P Wohrl S | 2004 | Circulation2004，110，17： | 1 |
| 20 | Gastmprotection by vitamin C-a heme oxygenase-l-dependent mechanism显示文摘 | BECKER JC CROSSER N BOKNIK P | 2003 | Biochem Biophys Res Commnun2003，312，2： | 1 |
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