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| 1 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Limitation of myocardial infarct size after primary angioplasty:Is a higher patency the only mechanism?显示文摘 | OTTERVANGER J P LIEM A De BOER M J | 1999 | Am Heart J1999，137，3： | 2 |
| 4 | Nutrient emissions from agriculture in the Netherland:causes and remedies显示文摘 | BOERS P C M | 1996 | Water Science Technology1996，33，： | 2 |
| 5 | Warming asymmey in climate change simulations显示文摘 | FLATO G M BOER G J | 2001 | Geophysical Research Letters2001，28，： | 1 |
| 6 | Agricultural nutrient losses to surface water in the Netherlands:Impact, strategies, and perspectives显示文摘 | Van Der Molen D T Breeuwsma A Boers P C M | 1998 | Journal of Environmentol Quality1998，27，1： | 1 |
| 7 | The diurnal inequality of the tide as a parameter for recognizing tidal influences显示文摘 | Boer P L Oost A P Visser M J | 1989 | Journal of Sedimentary Petrology1989，59，： | 1 |
| 8 | Chronic active Epstein-Barr virus infection in an adult with no detectable immune deficiency 显示文摘 | de Boer M Mol MJ Bogman MJ | 2003 | Neth J Med2003，61，11： | 1 |
| 9 | Re cent sedimentation and sediment accumulation rates of the Ba Lat prodelta(Red River, Vietnam) 显示文摘 | van den Bergh G D Boer W Schaapveld M A S | 2007 | Journal of Asian Earth Sciences2007，，29： | 1 |
| 10 | The global burden and stigma of epilepsy显示文摘 | de Boer HM Mula M SanderJW | 2008 | Epilepsy Behav2008，12，4： | 1 |
| 11 | Effects of prenatal steroids in the development of necrotizing enterocolitis in Wistar rat neonates 显示文摘 | Bortolin L Boer M Christiansen S | 2011 | Arch Argent Pediatr2011，109，1： | 1 |
| 12 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 13 | Exogenous administration of thiosulfate, a donor of Hydrogen sulfide, attenuates Angiotensin II-induced hypertensive heart disease in rats 显示文摘 | Snijder P M Frenay A S De Boer R A | 2014 | Br J Pharmacol2014，24，11： | 1 |
| 14 | Genetic polymor- phisms related to the renin-angiotensin-aldosterone system and response to antihypertensive drugs显示文摘 | Taverne K de Groot M de Boer A | 2010 | Expert Opin Drug Metab Toxicol2010，6，4： | 1 |
| 15 | Essential medicines are more available than other medicines around the globe 显示文摘 | Bazargani YT Ewen M De Boer A | 2014 | PLoS One2014，9，87： | 1 |
| 16 | Control of Fusarium wilt of radish by combining Pseudomonas putida strains that have different disease-suppressive mechanisms显示文摘 | de Boer M Born P Kindt F | 2003 | Phytopathology2003，93，5： | 1 |
| 17 | 一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。 | Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 1 |
| 18 | Coagulation disorders in septic shock 显示文摘 | Thijs L G de Boer J P de Groot M C | 1993 | Intensive Care Med1993，19，1： | 1 |
| 19 | Fatty acid export from the chloroplast molecular characterization of a major plastidial acyl-coenzyme a synthetase from Arabidopsis 显示文摘 | SCHNUR J A SHOCKEY J M BOER G I | 2002 | Plant Physiol2002，129，4： | 1 |
| 20 | Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy 显示文摘 | de Boer M J Ottervanger J P vant Hof A W | 2002 | J Am Coil Cardiol2002，39，11： | 1 |
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