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| 1 | Intravenous chemotherapy for resected gastric cancer:meta-analysis of randomized controlled trials显示文摘AIM: To assess the safety and efficacy of different intravenous chemotherapeutic regimens in patiedts with gastric acrcinomas who had undergone gastrectomy. | Jian-KunHu Zhi-xinChen Zong-GuangZhou BoZhang JingTian Jia-Pin | 2002 | World Journal of Gastroenterology2002，8，6： | 31 |
| 2 | Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer显示文摘AIM: The study of immune response of open versus laparoscopical total mesorectal excision with anal sphincter preservation in patients with rectal cancer has not been reported yet. The dissected retroperitoneal area that contacts directly with carbon dioxide is extensive in laparoscopic total mesorectal excision with anal sphincter preservation surgery. Tt is important to clarify whether the immune response of laparoscopic total mesorectal excision with anal sphincter preservation (LTME with ASP) in patients with rectal cancer is suppressed more severely than that of open surgery (OTME with ASP). This study was designed to compare the immune functions after laparoscopic and open total mesorectal excision with anal sphincter preservation for rectal cancer.METHODS: This study involved 45 patients undergoing laparoscopic (n=20) and open (n=25) total mesorectal excisions with anal sphincter preservation for rectal cancer.Serum interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor α (TNFα) were assayed preoperatively and on days 1 and 5 postoperatively. CD3+ and CD56+ T lymphocyte count, CD3- and CD56+ natural killer cell (NK)count and immunoglobulin (IgG/IgM/IgA) were assayed preoperatively and on day 5 postoperatively. The numbers of CD3+ and CD56+ T lymphocytes and CD3- and CD56+ NK cells were counted using flow cytometry. An enzyme-linked immunosorbent assay (ELISA) was used for IL-2, TL-6 and TNFα determination. And IgG, IgM, and IgA were assayed using immunonephelometry.RESULTS: The demographic data of the two groups had no difference. The preoperative levels of CD3+ and CD56+ T lymphocyte count, CD3- and CD56+ NK count, serum IgG,IgM, IgA, IL-2, IL-6 and TNFα also had no significant difference in the two groups (P>0.05). The CD3+ and CD56+ T lymphocyte counts had no obvious changes after surgery in laparoscopic (d=-0.79±3.83 %) and open (d=0.42±2.09 %)groups. The CD3- and CD56+ NK counts were decreased postoperatively in both laparoscopic (d=-7.23±11.33 %) and open (d=-9.21±13.93 %) groups. The differences of the determined values of serum IgG, IgM and IgA on the fifth day after operation subtracted those before operation were -2.56±2.14 g/L, -252.35±392.94 mg/L, -506.15±912.24 mg/L in laparoscopic group, and -1.81±2.10 g/L, -282.72±356.75mg/L, -252.20±396.28 mg/L in open group, respectively. The levels of IL-2 were decreased after operation in both groups.However, the levels of IL-6 were decreased after laparoscopic surgery (d1=-23.14±263.97 ng/L and d5=-40.08±272.03 ng/L),and increased after open surgery (d1=27.38±129.14 ng/L and d5=21.67±234.31 ng/L). The TNFα levels were not elevated after surgery in both groups. There were no significant differences in the numbers of CD3+ and CD56+ T lymphocytes and CD3- and CD56+ NK cells, the levels of IgG, IgM, IgA,IL-2, IL-6 and TNFα between the two groups (P>0.05).CONCLUSION: There are no differences in immune responses between the patients having laparoscopic total mesorectal excision with anal sphincter preservation and those undergone open surgery for rectal cancer. | Jian-KunHu Zong-GuangZhou Zhi-XinChen Lan-LanWang Yong-YangYu JinLiu BoZhang LiLi YeShu Jia-PingChen | 2003 | World Journal of Gastroenterology2003，9，12： | 23 |
| 3 | Tumor type M_2 pyruvate kinase expression in gastric cancer,colorectal cancer and controls显示文摘AIM: Tumor formation is generally linked to an expansion of glycolytic phosphometabolite pools and aerobic glycolytic flux rates. To achieve this, tumor cells generally overexpress a special glycolytic isoenzyme, termed pyruvate kinase type M2. The present study was designed to evaluate the use of a new tumor marker, tumor M2-PK, in discriminating gastrointestinal cancer patients from healthy controls, and to compare with the reference tumor markers CEA and CA72-4. METHODS: The concentration of tumor M2-PK in body fluids could be quantitatively determined by a commercially available enzyme-linked immunosorbent assay (ELISA)-kit (ScheBo(R) Tech, Giessen, Germany). By using this kit, the tumor M2-PK concentration was measured in EDTA-plasma of 108 patients. For the healthy blood donors a cut-off value of 15 U/mL was evaluated, which corresponded to 90% specificity. Overall 108 patients were included in this study, 54 patients had a histological confirmed gastric cancer, 54 patients colorectal cancer, and 20 healthy volunteers served as controls. RESULTS: The cut-off value to discriminate patients from controls was established at 15 U/mL for tumor M2-PK. The mean tumor M2-PK concentration of gastric cancer was 26.937 U/mL. According to the TNM stage system, the mean tumor M2-PK concentration of stage I was 16.324 U/mL, of stage II 15.290 U/mL, of stage Ⅲ 30.289 U/mL, of stage IV 127.31 U/mL, of non-metastasis 12.854 U/mL and of metastasis 35.711 U/mL. The mean Tumor M2-PK concentration of colorectal cancer was 30.588 U/mL. According to the Dukes stage system, the mean tumor M2-PK concentration of Dukes A was 16.638 U/mL, of Dukes B 22.070 U/mL, and of Dukes C 48.024 U/mL, of non-metastasis 19.501 U/mL, of metastasis 49.437 U/mL. The mean tumor M2-PK conoentration allowed a significant discrimination of colorectal cancers(30.588 U/mL) from controls (10.965 U/mL) (P<0.01), and gastric cancer (26.937 U/mL) from controls (10.965 U/mL)(P<0.05). The overall sensitivity of tumor M2-PK for colorectal cancer was 68.52%, while that of CEA was 43.12%. In gastric cancer, tumor M2-PK showed a high sensitivity of 50.47%, while CA72-4 showed a sensitivity of 35.37%. CONCLUSION: Tumor M2-PK has a higher sensitivity than markers CEA and CA72-4, and is a valuable tumor marker for the detection of gastrointestinal cancer. | BoZhang Jian-YingChen Dao-DaChen Guo-BinWang PingShen | 2004 | World Journal of Gastroenterology2004，10，11： | 22 |
| 4 | A Quotient Space Approximation Model of Multiresolution Signal Analysis显示文摘In this paper, we present a quotient space approximation model of multiresolution signal analysis and discuss the properties and characteristics of the model. Then the comparison between wavelet transform and the quotient space approximation is made. First, when wavelet transform is viewed from the new quotient space approximation perspective, it may help us to gain an insight into the essence of multiresolution signal analysis. Second, from the similarity between wavelet and quotient space approximations, it is possible to transfer the rich wavelet techniques into the latter so that a new way for multiresolution analysis may be found. | LingZhang BoZhang | 2005 | Journal of Computer Science & Technology2005，20，1： | 19 |
| 5 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 6 | PROLIFERATION AND DIFFERENTIATION OF NEURAL STEMCELLS IN ADULT RATS AFTER CEREBRAL INFARCTION显示文摘Objective To investigate proliferation and differentiation of neural stem cells in adult rats after cerebral infarction. Methods Models of cerebral infarction in rats were made and the time-course expression of bromodeoxyuridine(BrdU), Musashi1, glial fibrillary acidic protein (GFAP), and neuronal nuclear antigen (NeuN) were determined by immunohistochemistry and immunofluorescence staining. BrdU and Musashi1 were used to mark dividing neural stem cells. GFAP and NeuN were used to mark differentiating neural stem cells. Results Compared with controls, the number of BrdU-labeled and BrdU-labeled with Musashi1-positive cells incre-ased strikingly 1 day after cerebral infarction; approximately 6 fold with a peak 7 days later; markedly decreased 14 days later, but was still elevated compared with that of controls; decling to the control level 28 days later. The number of BrdU-labeled with GFAP-positive cells nearly remained unchanged in the hippocampus after cerebral infarction. The nu-mber of BrdU-labeled with NeuN-positive cells increased strikingly 14 days after cerebral infarction, reached maximum peak in the hippocampus 28 days after cerebral infarction in rats. Conclusion Cerebral infarction stimulate proliferation of inherent neural stem cells and most proliferated neural stem cells differentiate into neurons. | BoZhang Ren-zhiWang YongYao Zhi-haiLiu Zhi-gangLian Yu-jieZou Yu-kuiWei | 2004 | Chinese Medical Sciences Journal2004，19，2： | 5 |
| 7 | Dynamic and nonlinear properties of epitaxial quantum dot lasers on silicon for isolator-free integration显示文摘This work investigates the dynamic and nonlinear properties of quantum dot(QD) lasers directly grown on silicon with a view to isolator-free applications. Among them, the chirp parameter, also named the αHfactor,is featured through a thermally insensitive method analyzing the residual side-mode dynamics under optical injection locking. The αHat threshold is found as low as 0.32. Then, the nonlinear gain is investigated from the gain compression factor viewpoint. The latter is found higher for epitaxial QD lasers on silicon than that in heterogeneously integrated quantum well(QW) devices on silicon. Despite that, the power dependence of the αHdoes not lead to a large increase of the chirp coefficient above the laser’s threshold at higher bias. This effect is confirmed from an analytical model and attributed to the strong lasing emission of the ground-state transition, which transforms into a critical feedback level as high as-6.5 d B, which is ~19 d B higher than a comparable QW laser.Finally, the intensity noise analysis confirms that QD lasers are overdamped oscillators with damping frequencies as large as 33 GHz. Altogether, these features contribute to fundamentally enhancing the reflection insensitivity of the epitaxial QD lasers. This last feature is unveiled by the 10 Gbit/s error-free high-speed transmission experiments. Overall, we believe that this work is of paramount importance for future isolator-free photonics technologies and cost-efficient high-speed transmission systems. | Jianan Duan Heming Huang Bozhang Dong Justin C.Norman Zeyu Zhang John E.Bowers Frederic Grillot | 2019 | Photonics Research2019，7，11： | 4 |
| 8 | INHIBITORY ROLE OF TRANSCRIPTION FACTOR COUP-TFII IN EXPRESSION OF HTERT IN HELA CELLS显示文摘To clone and identify the proteins involved in regulating the transcription of hTERT and study the role of genes in both hTERT transcription and telomerase activity. Methods The full cDNA of COUP-TFII was cloned from HeLa cDNA library by hTERT promoter-based yeast one-hybrid assay and then in-frame inserted into His-tag fusion expression vector pEK318. The His-tag COUP-TFII fusion proteins were purified by Ni-NTA chromatography. The interaction of COUP-TFII with hTERT promoter in vitro was identified by electrophoretic mobility shift assay and Footprint. The role of COUP-TFII in both hTERT transcription and telomerase activity were probed through Luciferase reporter assay, Northern blot, and TRAP-PCR ELISA. Results COUP-TFII could firmly bind to the downstream E-box and the other two binding sites in hTERT promoter. Luciferase reporter assay indicated COUP-TFII could suppress hTERT promoter activity and stable introduction of COUP-TFII into HeLa cells also decreased both endogenous hTERT transcription and telomerase activity. Conclusion The human COUP-TFII can firmly bind to hTERT promoter, and inhibit telomerase activity through decreasing hTERT transcription. It will greatly facilitate understanding of telomerase regulation in normal and cancer | QiangWang Zeng-liangBai: LiXuan LinHou BoZhang | 2004 | Chinese Medical Sciences Journal2004，19，3： | 2 |
| 9 | 9 Waste Rubber Technologies Passed the Review on Advanced Applicable Technologies by MIIT显示文摘 | Qiart Bozhang | 2012 | 中国橡胶2012，28，12： | 2 |
| 10 | A 3D Coordination Framework Based on Linkages of Nanosized Hydroxo Lanthanide Clusters and Copper Centers by Isonicotinate Ligands显示文摘 | Man‐BoZhang JieZhang Shou‐TianZheng Guo‐YuYang | 2005 | Angewandte Chemie International Edition2005，，9： | 2 |
| 11 | The soybean Dof‐type transcription factor genes, GmDof4 and GmDof11, enhance lipid content in the seeds of transgenic Arabidopsis plants显示文摘 | Hui‐WenWang BoZhang Yu‐JunHao JianHuang Ai‐GuoTian YongLiao | 2007 | The Plant Journal2007，，4： | 2 |
| 12 | DNA damage in mice treated with sulfur dioxide by inhalation显示文摘 | ZiqiangMeng GuohuaQin BoZhang | 2005 | Environ Mol Mutagen2005，，3： | 1 |
| 13 | Pentylenetetrazole‐induced seizures cause acute, but not chronic, mTOR pathway activation in rat显示文摘 | BoZhang MichaelWong | 2012 | Epilepsia2012，，3： | 1 |
| 14 | Cloning and expression of mouse peroxiredoxin I in 1EC-6 Cells显示文摘AIM: To clone and express mouse peroxiredoxin Ⅰ in IEC-6 cells.METHODS: Total RNAs were isolated from cultured IEC-6 cells, and the coding region of peroxiredoxin I was amplified by RT-PCR. After it was cloned into T-vector and sequenced,pSG5 was used to transiently express peroxiredoxin I in IEC-6 by liposome-mediated transfection, and the expression of peroxiredoxin I was evaluated by RT-PCRand Western blot. RESULTS: A DNA fragment about 750 bp was amplified from total RNAs of IEC-6 cells using specific primers of peroxiredoxin Ⅰ. The sequencing confirmed the coding region was successfully cloned into T-vector, which was completely coincident with the sequence in GeneBank. After the EcoRI-BamHI fragment of T-vector containing peroxiredoxin I was inserted into pSG5, the recombinant plasmid was transferred to IEC-6 cells. RT-PCR assay showed that a DNA fragment of 930 bp could be amplified,which indicated the transcription of pSG5-Prx. Western blot confirmed the expression of peroxiredoxin Ⅰ in IEC-6 cells.CONCLUSION: Mouse peroxiredoxin I can be successfully expressed in IEC-6 cells. | BoZhang Yong-PingSu TaoWang Feng-ChaoWang Guo-PingAi HuiXu Jun-PingWang Yue-ShengHuang Jian-XinJiang | 2004 | World Journal of Gastroenterology2004，10，14： | 1 |
| 15 | Development status of the the plasticizer in domesticand oversea (part one)显示文摘 | Qian Bozhang | 2010 | Shanghai Chemical Industry2010，36，1： | 1 |
| 16 | Uncovering recent progress in nanostructured light-emitters for information and communication technologies显示文摘Semiconductor nanostructures with low dimensionality like quantum dots and quantum dashes are one of the best attractive and heuristic solutions for achieving high performance photonic devices.When one or more spatial dimensions of the nanocrystal approach the de Broglie wavelength,nanoscale size effects create a spatial quantization of carriers leading to a complete discretization of energy levels along with additional quantum phenomena like entangled-photon generation or squeezed states of light among others.This article reviews our recent findings and prospects on nanostructure based light emitters where active region is made with quantum-dot and quantum-dash nanostructures.Many applications ranging from silicon-based integrated technologies to quantum information systems rely on the utilization of such laser sources.Here,we link the material and fundamental properties with the device physics.For this purpose,spectral linewidth,polarization anisotropy,optical nonlinearities as well as microwave,dynamic and nonlinear properties are closely examined.The paper focuses on photonic devices grown on native substrates(InP and GaAs)as well as those heterogeneously and epitaxially grown on silicon substrate.This research pipelines the most exciting recent innovation developed around light emitters using nanostructures as gain media and highlights the importance of nanotechnologies on industry and society especially for shaping the future information and communication society. | Frédéric Grillot Jianan Duan Bozhang Dong Heming Huang | 2021 | Light(Science & Applications)2021，10，9： | 1 |
| 17 | Bifurcations and chaos in indirect field-oriented control of induction motors显示文摘Stability of indirect field-oriented control (IFOC) of induction motor drives is greatly influenced by estimated value of rotor time constant.By choosing estimation error of rotor time constant as bifurcation parameter,the conditions of generating Hopf bifurcation in IFOC drives are analyzed.Dynamic responses and Lyapunov exponents show that chaos and limit cycles will arise for some ranges of load torque with certain PI speed controller setting.Stable drives are required for conventional applications,but chaotic rotation can promote efficiency or improve dynamic characteristics of drives.Thus,the study may be a guideline for designing a stable system or an oscillating system. | BoZHANG YiminLU ZongyuanMAO | 2004 | 控制理论与应用(英文版)2004，2，4： | 1 |
| 18 | Postharvest temperature influences volatile lactone production via regulation of acyl‐CoA oxidases in peach fruit显示文摘 | WAN‐PENGXI BOZHANG LILIANG JI‐YUANSHEN WEN‐WENWEI CHANG‐JIEXU ANDREW C.ALLAN IAN B.FERGUSON KUN‐SONGCHEN | 2012 | Plant Cell & Environment2012，，3： | 1 |
| 19 | The market analysis of caprolactam显示文摘 | Qian Bozhang | 2013 | Chem Ind2013，31，1： | 1 |
| 20 | Dynamic performance and reflection sensitivity of quantum dot distributed feedback lasers with large optical mismatch显示文摘This work reports on a high-efficiency In As/Ga As distributed feedback quantum dot laser.The large optical wavelength detuning at room temperature between the lasing peak and the gain peak causes the static,dynamic,and nonlinear intrinsic properties to all improve with temperature,including the lasing efficiency,the modulation dynamics,the linewidth enhancement factor,and consequently the reflection insensitivity.Results reported show an optimum operating temperature at 75°C,highlighting the potential of the large optical mismatch assisted single-frequency laser for the development of uncooled and isolator-free high-speed photonic integrated circuits. | BOZHANG DONG JIANAN DUAN HEMING HUANG JUSTIN CNORMAN KENICHI NISHI KEIZO TAKEMASA MITSURU SUGAWARA JOHN EBOWERS FRéDéRIC GRILLOT | 2021 | Photonics Research2021，9，8： | 1 |
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