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| 1 | Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure显示文摘AIM: To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure (CRF).METHODS: Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori (H pylori) and CRF status. Groups were labeled as follows: 1a: normal renal function, H pylori negative (n = 12), 1b: normal renal function,H pylori positive (n = 11), 2a: CRF, H pylori negative (n = 10), 2b: CRF, H pylori positive (n = 11). Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation,antral biopsy specimens were taken from each patient.In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen (PCNA) labeling indexes (LI) were assessed with immunohistochemical staining method.RESULTS: For groups 1a, 1b, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5,60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22,respectively. When the one-way ANOVA test was applied,statistically significant differences were detected between the groups for both Bax LI (P = 0.004 <0.01) and PCNA LI (P = 0.009 <0.01). When groups were compared further in terms of Bax LI and PCNA LI with Tukey's HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups 1a and 2b (P = 0.006 <0.01).CONCLUSION: In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells. | Selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 2 | Preparation and in vitro bioactivity of CaSiO3 powders显示文摘 | Binnaz Yoruc Hazar A | 2007 | Cercmies International2007，33，4： | 1 |
| 3 | Determinants of alveolar ridge preservation differ by anatomic location显示文摘 | Binnaz Leblebicioglu Mabel Salas Yirae Ort Ashley Johnson Vedat O. Yildiz Do‐Gyoon Kim Sudha Agarwal Dimitris N. Tatakis | 2013 | J Clin Periodontol2013，，4： | 1 |
| 4 | comfort properties of different in cycling clothes 显示文摘 | OZKAN Thermophysiological knitted fabrics used Tastan MERIC Binnaz | 2015 | Textile Research Journal2015，85，1： | 1 |
| 5 | Salivary detection of periodontopathicbacteria and periodontal health status in dental students 显示文摘 | Binnaz L Guven K | 2009 | Anaerobe2009，15，3： | 1 |
| 6 | Effect of early water contact on solubility of glass ionomer Luting cements 显示文摘 | Deniz Gemalmaz Binnaz Yoruc Mutlu Ozcan | 1998 | J Prosthet Dent1998，80，4： | 1 |
| 7 | Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene:A case report显示文摘BACKGROUND Cytotoxic T Lymphocyte Antigen-4(CTLA4)deficiency is a genetic defect that causes a common variable immunodeficiency(CVID)clinical phenotype.Several studies have reported an association between CTLA mutations or variants and various autoimmune diseases.Targeted therapy models,which have become increasingly popular in recent years,have been successful in treating CTLA4 deficiency.In this article,we discuss the clinical outcomes of abatacept treatment in a patient with CTLA4 and lipopolysaccharide-responsive beige-like anchor(LRBA)variants that was previously diagnosed with CVID.CASE SUMMARY A 25-year-old female patient,who was visibly cachectic,visited our clinic over the course of five years,complaining of diarrhea.The patient was diagnosed with ulcerative colitis in the centers she had visited previously,and various treatments were administered;however,clinical improvement could not be achieved.Severe hypokalemia was detected during an examination.Her serum immunoglobulin levels,CD19+B-cell percentage,and CD4/CD8 ratio were low.An endoscopic examination revealed erosive gastritis,nodular duodenitis,and pancolitis.Histopathological findings supported the presence of immune mediated enteropathy.When the patient was examined carefully,she was diagnosed with CVID,and intravenous immunoglobulin treatment was initiated.Peroral and rectal therapeutic drugs including steroid therapy episodes were administered to treat the immune mediated enteropathy.Strict follow-ups and treatment were performed due to the hypokalemia.After conducting genetic analyses,the CTLA4 and LRBA variants were identified and abatacept treatment was initiated.With targeted therapy,the patient’s clinical and laboratory findings rapidly regressed,and there was an increase in weight.CONCLUSION The heterozygous CTLA4 variant identified in the patient has been previously shown to be associated with various autoimmune diseases.The successful clinical outcome of abatacept treatment in this patient supports the idea that this variant plays a role in the immunopathogenesis of the disease.In the presence of severe disease,abatacept therapy should be considered until further testing can be conducted. | Ugur Musabak Tuba Erdoğan Serdar Ceylaner EmreÖzbek Nuretdin Suna Binnaz HandanÖzdemir | 2023 | World Journal of Clinical Cases2023，11，26： | 0 |
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