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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of clinical management of stroke rehabilitation显示文摘Stroke is the third leading cause of long-term disability.Effective stroke rehabilitation should be provided to patients with a moderate or severe stroke so as to achieve functional recovery.Also,stroke rehabilitation is moving towards more intense therapy models that incorporate technologies such as robotics and computer games.Evidence-based guidelines are useful for promoting the best possible clinical practices.This guideline summarises the modes of stroke rehabilitation in China-three-stage rehabilitation network,rehabilitation of stroke dysfunction,training for activities of daily living,stroke complications and rehabilitation care.The aim of this guideline was to provide a synopsis of best clinical practices in the stroke rehabilitation of adult patients in China. | Tong Zhang Jun Zhao Xueping Li Yulong Bai Baojun Wang Yun Qu Bingjie Li Shengjie Zhao Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020,5,3: | 38 |
| 2 | Overview of Mechanism and Mitigation Measures on Multi-frequency Oscillation Caused by Large-scale Integration of Wind Power显示文摘In recent years,the large-scale integration of re-newable energy sources represented by wind power and the widespread application of power electronic devices in power systems have led to the emergence of multi-frequency oscillation problems covering multiple frequency segments,which seriously threaten system stability and restrict the accommodation of renewable energy.The oscillation problems related to renewable energy integration have become one of the most popular topics in the field of wind power integration and power system stability research.It has received extensive attention from both academia and industries with many promising research results achieved to date.This paper first analyzes several typical multi-frequency oscillation events caused by large-scale wind power integration in domestic and foreign projects,then studies the multi-frequency oscillation problems,including wind turbine’s shafting torsional oscillation,sub/super-synchronous oscillation and high frequency resonance.The state of the art is systematically summarized from the aspects of oscillation mechanism,analysis methods and mitigation measures,and the future research directions are explored. | Yongning Chi Bingjie Tang Jiabing Hu Xinshou Tian Haiyan Tang Yan Li Sujuan Sun Lei Shi Lei Shuai | 2019 | CSEE Journal of Power and Energy Systems2019,5,4: | 23 |
| 3 | Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization显示文摘 | Yuli Lin Xuguang Yang Wenjie Yue Xiaofei Xu Bingji Li Linlin Zou Rui He | 2014 | Cellular & Molecular Immunology2014,11,4: | 21 |
| 4 | Molecular mechanisms governing plant responses to high temperatures显示文摘The increased prevalence of high temperatures(HTs) around the world is a major global concern, as they dramatically affect agronomic productivity. Upon HT exposure, plants sense the temperature change and initiate cellular and metabolic responses that enable them to adapt to their new environmental conditions.Decoding the mechanisms by which plants cope with HT will facilitate the development of molecular markers to enable the production of plants with improved thermotolerance. In recent decades, genetic, physiological, molecular, and biochemical studies have revealed a number of vital cellular components and processes involved in thermoresponsive growth and the acquisition of thermotolerance in plants. This review summarizes the major mechanisms involved in plant HT responses, with a special focus on recent discoveries related to plant thermosensing, heat stress signaling, and HT-regulated gene expression networks that promote plant adaptation to elevated environmental temperatures. | Bingjie Li Kang Gao Huimin Ren Wenqiang Tang | 2018 | Journal of Integrative Plant Biology2018,60,9: | 19 |
| 5 | Adsorption of Heavy Metal Ions,Dyes and Proteins by Chitosan Composites and Derivatives-A Review显示文摘Chitosan composites and derivatives have gained wide attentions as effective biosorbents due to their low costs and high contents of amino and hydroxyl functional groups.They have showed significant potentials of removing metal ions,dyes and proteins from various media.Chemical modifications that lead to the formation of the chitosan derivatives and chitosan composites have been extensively studied and widely reported in literatures.The aims of this review were to summarize the important information of the bioactivities of chitosan,highlight the various preparation methods of chitosan-based active biosorbents,and outline its potential applications in the adsorption of heavy metal ions,dyes and proteins from wastewater and aqueous solutions. | LIU Bingjie WANG Dongfeng YU Guangli MENG Xianghong | 2013 | Journal of Ocean University of China2013,12,3: | 15 |
| 6 | Novel CeO_2@TiO_2 core–shell nanostructure catalyst for selective catalytic reduction of NOx with NH_3显示文摘The CeO_2@TiO_2 core-shell nanostructure catalyst prepared by a two-step hydrothermal method was used for selective catalytic reduction(SCR) of NOx with NH_3 in this study.The catalyst presented the obvious core-shell structure,and the shell was amorphous TiO_2which could protect the active center from the SO_2 erosion.The catalyst showed high activity and stability,excellent N_2 selectivity and superior SO_2 resistance and H_2O tolerance.Characterizations such as TEM,HR-TEM,XRD,BET,XPS,NH_3-TPD,and H_2-TPR were carried out.The results indicated that the catalyst had large surface area and the active sites were well dispersed on the surface.The NH_3-TPD,H_2-TPR and XPS results implied that its increased SCR activity might be due to the enhancement of NH_3 chemisorption and the increase of active oxygen species,both of which were conductive to NH_3 activation.The excellent catalytic performance suggests that it is a promising candidate for SCR catalyst. | Bingjie Huang Danqing Yu Zhongyi Sheng Liu Yang | 2017 | Journal of Environmental Sciences2017,29,5: | 15 |
| 7 | Role of plant autophagy in stress response显示文摘Autophagy is a conserved pathway for the bulk degradation of cytoplasmic components in all eukaryotes.This process plays a critical role in the adaptation of plants to drastic changing environmental stresses such as starvation,oxidative stress,drought,salt,and pathogen invasion.This paper summarizes the current knowledge about the mechanism and roles of plant autophagy in various plant stress responses. | Shaojie Han Bingjie Yu Yan Wang Yule Liu | 2011 | Protein & Cell2011,2,10: | 15 |
| 8 | Sinomenine reduces iNOS expressionvia inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats显示文摘Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum.It is widely used as an immunosuppressive drug for treating rheumatic and arthritic diseases.In our previous studies,we found that sinomenine reduced cellular infiltration within the spinal cord and alleviated experimental autoimmune encephalomyelitis(EAE) in rats.In this study,we further investigated the mechanisms of sinomenine treatment in EAE rats.In EAE rats,treatment with sinomenine exerted an anti-inducible NO synthase(anti-iNOS) effect,which is related to the reductions of Th1 cytokine interferon-γ(IFN-γ) and its transcription factor,T-bet,in spinal cords.Moreover,sinomenine treatment of splenocytes stimulated with anti-CD3 antibody and recombinant rat interleukin 12 reduced the expression of T-bet and IFN-γ in vitro and also reduced the capability of supernatants of splenocyte culture to induce iNOS expression by primary astrocytes.However,sinomenine had no direct inhibitory effect on iNOS produced by astrocytes cultured with IFN-γ and tumor necrosis factor α in vitro.In conclusion,the anti-iNOS effect of sinomenine on EAE is mediated via the suppression of T-bet /IFN-γ pathway. | Bingjie Gu Yanying Zeng Cheng Yin Huijiuan Wang Xiaofan Yang Song Wang Xiaohui Ji | 2012 | The Journal of Biomedical Research2012,26,6: | 11 |
| 9 | FKF1 F-box protein promotes flowering in part by negatively regulating DELLA protein stability under long-day photoperiod in Arabidopsis^FA显示文摘FLAVIN-BINDING KELCH REPEAT F-BOX 1(FKF1)encodes an F-box protein that regulates photoperiod flowering in Arabidopsis under long-day conditions(LDs).Gibberellin(GA)is also important for regulating flowering under LDs.However,how FKF1 and the GA pathway work in concert in regulating flowering is not fully understood.Here,we showed that the mutation of FKF1 could cause accumulation of DELLA proteins,which are crucial repressors in GA signaling pathway,thereby reducing plant sensitivity to GA in flowering.Both in vitro and in vivo biochemical analyses demonstrated that FKF1 directly interacted with DELLA proteins.Furthermore,we showed that FKF1 promoted ubiquitination and degradation of DELLA proteins.Analysis of genetic data revealed that FKF1 acted partially through DELLAs to regulate flowering under LDs.In addition,DELLAs exerted a negative feedback on FKF1 expression.Collectively,these findings demonstrate that FKF1 promotes flowering partially by negatively regulating DELLA protein stability under LDs,and suggesting a potential mechanism linking the FKF1 to the GA signaling DELLA proteins. | Jindong Yan Xinmei Li Bingjie Zeng Ming Zhong Jiaxin Yang Piao Yang Xin Li Chongsheng He Jianzhong Lin Xuanming Liu Xiaoying Zhao | 2020 | Journal of Integrative Plant Biology2020,62,11: | 8 |
| 10 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015,47,8: | 8 |
| 11 | A learning method for energy optimization of the plug-in hybrid electric bus显示文摘The optimal energy management for a plug-in hybrid electric bus(PHEB)running along the fixed city bus route is an important technique to improve the vehicles’fuel economy and reduce the bus emission.Considering the inherently high regularities of the fixed bus routes,the continuous state Markov decision process(MDP)is adopted to describe a cost function as total gas and electric consumption fee.Then a learning algorithm is proposed to construct such a MDP model without knowing the all parameters of the MDP.Next,fitted value iteration algorithm is given to approximate the cost function,and linear regression is used in this fitted value iteration.Simulation results show that this approach is feasible in searching for the control strategy of PHEB.Simultaneously this method has its own advantage comparing with the CDCS mode.Furthermore,a test based on a real PHEB was carried out to verify the applicable of the proposed method. | SUN Yong CHEN Zheng YAN BingJie YOU SiXiong | 2015 | Science China(Technological Sciences)2015,58,7: | 7 |
| 12 | Effect of electro-acupuncture combined with psychological intervention on mental symptoms and P50 of auditory evoked potential in patients with internet addiction disorder显示文摘OBJECTIVE: To observe the therapeutic effects of electro-acupuncture(EA) combined with psychological intervention on the symptom of somzatization or obsession and mental symptom of depression or anxiety and P50 of Auditory Evoked Potential(AEP) on internet addiction disorder(IAD).METHODS: One hundred and twenty cases of IAD were randomly divided into an EA group, a psycho-intervention(PI) group and a comprehensive therapy(EA plus PI) group. Patients in the EA group were treated with EA. Patients in the PI group were treated with cognition and behavior therapy. Patients in the EA plus PI group were treated with electro-acupuncture plus psychological intervention. Scores of IAD, scores of the symptom checklist90(SCL-90), latency and amplitude of P50 of AEP were measured before and after treatment.RESULTS: The scores of IAD after treatment significantly decreased in all groups(P < 0.05), and thescores of IAD in the EA plus PI group were significantly lower than those in the other two groups(P < 0.05). The scores of SCL-90 assembled and each factor after treatment in the EA plus PI group significantly decreased(P < 0.05). After treatment in the EA plus PI group, the amplitude distance of S1P50 and S2P50(S1-S2) significantly increased(P < 0.05).CONCLUSION: EA combined with PI could relieve the mental symptoms of IAD patients, and the mechanism is possibly related to the increase of cerebrum sense perception gating function. | Li Hui Jin Rongjiang Yuan Kezhu Zheng Bo Zheng Zhong Luo Ying Ye Hua Huang Bingjie Zhu Tianmin | 2017 | Journal of Traditional Chinese Medicine2017,37,1: | 7 |
| 13 | Synthesis of hexaaluminate catalysts for methane combustion by reverse microemulsion medium显示文摘The aim of this study is to synthesize the catalysts of Fe-and Mn-substituted hexaaluminate by reverse microemulsion medium for methane catalytic combustion application.Pseudo-ternary phase diagrams in quaternary microemulsion systems of cetyltrimethylammonium bromide(CTAB),n-butanol,n-octane,and water [or Al(NO3)3 solution] were presented.The effects of the alcohol chain length,ratio of sur-factant to cosurfactant,and salt concentration on the formation and stability of microemulsion systems were studied.The phase behavior of microemulsion systems was confirmed through the varying of the conductivity with the water content.The performance and structure of the catalysts,La(Mnx/Fex)Al12-x-O19-δ synthesized with the optimal parameter in the phase diagrams of microemulsions systems were characterized by BET,TG-DTA,and XRD.The micro fix-bed reactor was used to measure the catalytic activities of catalysts to methane combustion.The results showed that this synthesis method could yield non-agglomerated and highly dispersed precursors that would undergo crystallization at the lower temperature of 950℃.When temperature was raised up to 1050℃,the complete crystalline La-hexaaluminate was shaped.The hexaaluminate substituted with Fe had high-catalytic activity and stability at high temperature,while the Mn-substituted had higher catalytic activity at lower temperature.When the cooperation of Fe and Mn occurred,i.e.,LaFeMnAl10O19-δ exhibited a high surface area and catalytic activity to CH4 combustion,the CH4 light-off temperature was only 475℃ and the complete combustion temperature was 660℃.This was attributed to the synergistic effect between Fe and Mn. | BAI ShouLi WANG LiangShi SHI BingJie YANG PengCheng CUI MeiSheng LONG ZhiQi LI DianQing CHEN AiFan | 2009 | Science China Chemistry2009,52,1: | 6 |
| 14 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77hkf55vcfwfbok6cpp.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021,6,10: | 6 |
| 15 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020,30,10: | 6 |
| 16 | Formation of Poly(ε-caprolactone) Networks via Supramolecular Hydrogen Bonding Interactions显示文摘In this contribution, we reported a novel approach to crosslink poly(ε-caprolactone)(PCL) via supramolecular hydrogen bonding interactions. First, a series of octa-armed poly(ε-caprolactone) stars with polyhedral oligomeric silsesquioxane(POSS) cores were synthesized via the ring-opening polymerizations. Thereafter, the arm ends of organic-inorganic star-shaped PCLs were reacted with 2-(6-isocyanatohexylaminocarbonylamino)-6-methyl-4[1 H]-pyrimidinone to obtain 2-ureido-4[1 H]-pyrimidone(UPy)-terminated PCL stars.Notably, the UPy-terminated PCL stars were physically crosslinked, which was evidenced by means of dynamic mechanical thermal analysis(DMTA) and rheological analysis. Owing to the formation of the physically-crosslinked networks, the organic-inorganic PCL stars displayed significant shape memory properties with about 100% of shape recovery, which was in marked contrast to the PCL stars without UPy termini. | Sen Xu Pengfei Chang Bingjie Zhao Muhammad Adeel Sixun Zheng | 2019 | Chinese Journal of Polymer Science2019,37,3: | 5 |
| 17 | LMI approach for absolute stability of general neutral type Lurie indirect control systems显示文摘This paper deals with the problem of the absolute stability for general neutral type Lurie indirect control systems by Lyapunov method and linear matrix inequality (LMI) technique. Delay_dependent sufficient conditions for the absolute stability are derived and expressed as the feasibility problem of LMI, which can be easily solved by Matlab Toolbox. Finally, some examples are provide to demonstrate the effectiveness of proposed method. | Bingji XU Qun WANG | 2005 | 控制理论与应用(英文版)2005,3,4: | 5 |
| 18 | Screen efficiency comparisons of decision tree and neural network algorithms in machine learning assisted drug design显示文摘In view of huge search space in drug design, machine learning has become a powerful method to predict the affinity between small molecular drug and targeting protein with the development of artificial intelligence technology. However, various machine learning algorithms including massive different parameters make the prediction framework choice to be quite difficult. In this work, we took a recent drug design competition(from XtalPi company on the DataCastle platform) as the typical case to find the optimized parameters for different machines learning algorithms and the most effective algorithm. After the parameter optimizations, we compared the typical machine learning methods as decision tree(XGBoost, LightGBM) and artificial neural network(MLP, CNN) with root-mean-square error(RMSE) and coefficient of determination(R^2) evaluation. As a result, decision tree is more effective than the neural network as LightGBM>XGBoost>CNN>MLP in the affinity prediction of the specific drug design problem with ~160000 samples. For a much larger screening task in a more complicated drug design study, the sophisticated neural network model may go beyond the decision tree algorithm after generalization enhancing and overfitting reducing. The advanced machine learning methods could extract more information of protein-ligand bindings than traditional ones and improve the screen efficiency of drug design up to 200–1000 times. | Qiumei Pu Yinghao Li Hong Zhang Haodong Yao Bo Zhang Bingji Hou Lin Li Yuliang Zhao Lina Zhao | 2019 | Science China Chemistry2019,62,4: | 5 |
| 19 | Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells显示文摘越来越多的研究建议了 type-2 糖尿病导致的 methylglyoxal (MGO ) 与 Parkinson 的疾病(PD ) 有关。然而,很少对分子的机制被知道。在这研究,我们在 neuroblastoma SH-SY5Y 房间探索了 MGO 毒性。MGO 的 Neurotoxicity 被 mitochondrial 膜潜力, malondialdehyde,和 methylthiazoletetrazolium 试金测量。多巴胺, 3,4-dihydroxyphenylacetic 酸(DOPAC ) ,和 1-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (salsolinol ) 的层次被液体 chromatographymass spectrometry/mass spectrometry 检测。酷氨酸 hydroxylase (TH ) 和多巴胺 transporter (DAT ) 的表情被反向的 transcriptase 聚合酶链反应和西方的污点分析检测。当多巴胺, DOPAC,和内长的神经毒素 salsolinol 的层次也增加了时,结果证明 MGO 在 SH-SY5Y neuroblastoma 房间在 TH 和 DAT 表情导致了增加。Aminoguanidine (AG ) 是 MGO 的一个禁止者。AG 能减少,这被发现反应的氧种类(ROS ) 水平由 MGO 导致了,但是不能禁止 TH, DAT 和多巴胺的增加。多巴胺, DOPAC 和 salsolinol 层次的增加能导致高 ROS 和 mitochondrial 损坏。当 MGO 在糖尿病的功课期间被增加时,这研究建议多巴胺引起的 ROS 能贡献 dopaminergic 神经原的损坏。 | Bingjie Xie Fankai Lin Lei Peng Kaleem Ullah Hanyan Wu Hong Qing Yulin Deng | 2014 | Acta Biochimica et Biophysica Sinica2014,46,11: | 4 |
| 20 | Effect of cross-section shape of rotating chute on particle movement and distribution at the throat of a bell-less top blast furnace显示文摘Rotating chutes are widely used to control the burden distribution and enhance the gas distribution in a blast furnace.The chute cross-section shape has a significant effect on the particle movement and distribution.Therefore,this study developed a three-dimensional model of a blast furnace top with rotating chute using the discrete element method.The effect of different chute shapes on the particle movement and radial burden distribution was then investigated.The results showed that the burden stream height at the chute discharge agrees well with the burden stream thickness at the burden surface.A semicircular chute had the largest main striking point,where the chute discharge joins the burden surface,and trapezoidal and rectangular chutes had successively smaller MSPs.The semicircular chute helped to obtain a uniform radial size distribution.The trapezoidal chute helped form an aggregated burden stream at low rotating speeds,while the rectangular shape chute achieved this at higher rotating speeds and different chute angles. | Mingyin Kou Jian Xu Shengli Wu Heng Zhou Kai Gu Shun Yao Bingjie Wen | 2019 | Particuology2019,17,3: | 3 |