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| 1 | Embryonic stem cell factors and pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC),the most common type of pancreatic tumor,is a highly aggressive human cancer with the lowest five-year survival rate of any human maligancy primarily due to its earlymetastasis and lack of response to chemotherapy and radiation.Recent research suggests that PDAC cells comprise a hierarchy of tumor cells that develop around a population of cancer stem cells(CSCs),a small and distinct population of cancer cells that mediates tumoregenesis,metastasis and resistance to standard treatments.Thus,CSCs could be a target for more effective treatment options.Interestingly,pancreatic CSCs are subject to regulation by some of key embryonic stem cell(ESC)transctiption factors abberently expressed in PDAC,such as SOX2,OCT4 and NANOG.ESC transcription factors are important DNA-binding proteins present in both embryonic and adult somatic cells.The critical role of these factors in reprogramming processes makes them essential not only for embryonic development but also tumorigenesis.Here we provide an overview of stem cell transcription factors,particularly SOX2,OCT4,and NANOG,on their expression and function in pancreatic cancer.In contrast to embryonic stem cells,in which OCT4 and SOX2 are tightly regulated and physically interact to regulate a wide spectrum of target genes,de novo SOX2 expression alone in pancreatic cancer cells is sufficient to promote self-renewal,dedifferentiation and imparting stemness characteristics via impacting specific cell cycle regulatory genes and epithelial-mesnechymal transtion driver genes.Thus,targeting ESC factors,particularly SOX2,could be a worthy strategy for pancreatic cancer therapy. | Marta Herreros-Villanueva Luis Bujanda Daniel D Billadeau Jin-San Zhang | 2014 | World Journal of Gastroenterology2014，20，9： | 5 |
| 2 | NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independ ent regulatory pathway显示文摘 | Billadeau DD Upshaw JL Schoon RA etal | 2003 | Nat Immunol2003，4，： | 1 |
| 3 | Characterization of theCXCR4 signaling in pancreatic cancer cells显示文摘 | Billadeau D D Chatterjee S Bramati P | 2006 | Int J GastrointestCancer2006，37，4： | 1 |
| 4 | Characterization of the CXCR4 signaling in pancreatic cancer cells 显示文摘 | Billadeau DD Chatterjee S Bramati P | 2006 | Int J Gastrointest Cancer2006，37，4： | 1 |
| 5 | Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2显示文摘 | Ougolkov A V Bilim V N Billadeau D D | 2008 | Clin Cancer Res2008，14，21： | 1 |
| 6 | Thetandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis显示文摘 | Kim JE Billadeau DD Chen JJ | 2005 | J Biol Chem2005，280，7： | 1 |
| 7 | Analysis of B- lymphoid malignancies using allele-specific polymerase chain re- action a technique for sequential quantitation of residual disease 显示文摘 | Billadeau D Blackstadt M Greipp P | 1991 | Blood1991，78，： | 1 |
| 8 | Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76显示文摘 | Charvet C Canonigo AJ Billadeau DD | 2005 | J Biol Chem2005，280，15： | 1 |
| 9 | Regulation of pan- ereatic tumor cell proliferation and chemoresistanee by the histone methyltransferase enhancer of zeste homologue 2 显示文摘 | Ougolkov AV Bilim YN Billadeau DD | 2008 | Clin Cancer Res2008，14，21： | 1 |
| 10 | Targeting GSK-3:a promising approach for cancer therapy显示文摘 | Ougolkov A V Billadeau D D | | 0，，01： | 1 |
| 11 | Analysis of B lymphoid malignancies using allele specific polymerase chain reaction: a technique for sequential quantitation of residual disease显示文摘 | Billadeau D Blackstadt M Greipp P | 1991 | Blood1991，78，： | 1 |
| 12 | Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis显示文摘 | Samar H. Ibrahim Yuko Akazawa Sophie C. Cazanave Steven F. Bronk Nafisa A. Elmi Nathan W. Werneburg Daniel D. Billadeau Gregory J. Gores | 2010 | Journal of Hepatology2010，，4： | 1 |
| 13 | VAV proteins as signal integrators for multi-subunit immune-recognition receptors显示文摘 | TURNER M BILLADEAU D D | 2002 | Nature Reviews Immunology2002，2，47： | 1 |
| 14 | The Rac effector p67^phox regulates phagocyte NADPH oxidase by stimulating Vavl guanine nucleotide exchange activity 显示文摘 | Ming W Li S Billadeau DD | 2007 | Mol Cell Biol2007，27，1： | 1 |
| 15 | Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2显示文摘 | Jevremovic D Billadeau D D Schoon A R | 2001 | J Immunol2001，166，： | 1 |
| 16 | Targeting GSK-3:a promising approach for cancer therapy?显示文摘 | Billadeau DD | 2006 | Future Oncol2006，2，1： | 1 |
| 17 | Regulationof pancreatic tumor cell proliferation and chemoresistance by thehistone methyltransferase enhancer of zeste homologue 2 显示文摘 | OUGOLKOV AV BILIM VN BILLADEAU DD | 2008 | Clin Cancer Res2008，14，21： | 1 |
| 18 | Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity显示文摘 | Stebbins C C Watzl C Billadeau D D | 2003 | Mol Cell Biol2003，23，17： | 1 |
| 19 | Introduction of an activated N-ras oncogene alters the growth chracteristics of the interleukin6 dependent myeloma cell line ANBL6显示文摘 | Billadeau D Jelinek DF Shan N | 1995 | Cancer Res1995，55，16： | 1 |
| 20 | Vav proteins as signal integrators for mul- tisubunit immune-recognition receptors显示文摘 | Turner M Billadeau DD | 2002 | Nat Rev Immunol2002，2，7： | 1 |
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