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| 1 | In-vitro antimicrobial activity of marine actinobacteria against multidrug resistance Staphylococcus aureus显示文摘Objective:To investigate the antibacterial aclivily of marine actinobacteria against multidrug resistance Staphylococcus aureus(MDRSA).Methods:Fifty one actinobacterial strains were isolated from salt pans soil,costal area in Kothapattanam,Ongole,Andhra Pradesh.Primary screening was done using cross-streak method against MDRSA.The bioaclive compounds are extracted from efficient actinobacteria using solvent extraction.The antimicrobial activity of crude and solvent extracts was perfomied using Kirby-Bauer method.MIC for ethyl acetate extract was determined by modified agar well diffusion method.The potent actinobacteria are identified using Nonomura key,Shirling and Gottlieb 1966 with Bergey's manual of determinative bacteriology.Results:Among the fifty one isolates screened for antibacterial activity,SRB25were found efficient against MDRSA.The ethyl acetate extracts showed high inhibition against test organism.MIC test was performed with the ethyl acetate extract against MDRSA and found to be 1 000μg/mL.The isolaled actinobacteria are identified as Streptomyces sp with the help of Nonomura key.Conclusions:The current investigation reveals that the marine actinobacteria from salt pan environment can be able to produce new drug molecules against drug resistant microorganisms. | Sathish Kumar SR Kokati Venkata Bhaskara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 5 |
| 2 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 3 | Antioxidant activity of newly discovered lineage of marine actinobacteria显示文摘Objective:To investigate the antioxidant activity of marine actinobacteria.Methods:The content of total phenolics,the level of antioxidant potential by DPPH radical scavenging activity,metal chelating activity,FRAP method,βcarotene assay and NO scavenging activity in extract were determined.Results:In all the methods the extract exhibited good scavenging activity except NO scavenging activity.The IC50 values of marine actinobacteria extract on DPPH radical were found to be 41.09μg/mL.The zone of color retention was 12 mm inβ-carotene bleaching assay. DNA protective efficiency of the extracts was also studied using UV- photolysed H2O2-driven oxidative damage to pBR322.HPLC analysis identified some of the major phenolic compounds in extracts,which might he responsible for the antioxidant potential and cyto-protection.It showed a 100%cytotoxic effect in brine shrimp lethality assay within 10 mins.The novel actinobacteria was identified as Streptomyces LK-3(JF710608) through I6S rDNA Sequencing.Conclusions:The results obtained suggest that the extracts bear anti-cancer metabolites and could be considered as a potential source for anti-cancer drug development. | Loganathan Karthik Gaurav Kumar Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 3 |
| 4 | Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa显示文摘Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(C.gigantea)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(H.bispinosa).Methods:The lyophilized C.gigantea flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 h.Synthesized TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of H.bispinosa were exposed to filter paper impregnated method.Results:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 nm.The functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for C-O.SEM micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in shape.The maximum efficacy was observed in the aqueous flower extract of C.gigantea and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against H.bispinosa(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).respectively.Conclusions:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of H.bispinosa.This study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity. | Sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai Siva Loganathan Karthik Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 2 |
| 5 | Do economic, financial and institutional developments matter for environmental degradation? Evidence from transitional economies显示文摘 | Artur Tamazian B. Bhaskara Rao | 2009 | Energy Economics2009，，1： | 2 |
| 6 | Complete convergence and almost sure convergence of weighted sums of random variables显示文摘 | Deli Li M. Bhaskara Rao Tiefeng Jiang Xiangchen Wang | 1995 | Journal of Theoretical Probability1995，，1： | 1 |
| 7 | Carotid artery remodeling in Acute Coronary Syndrome and Chronic Stable Angina显示文摘 | N. Rama Kumari I. Bhaskara Raju M. Aruna Devi J. Rama Krishna K. Sridhar Babu V.S.R. Bhopal Venkata Shivakrishna B. Moksha Prasanna | 2014 | Journal of Indian College of Cardiology2014，，： | 1 |
| 8 | The chemistry of dicalcium silicate mineral显示文摘 | Surendra N. Ghosh P. Bhaskara Rao A. K. Paul K. Raina | 1979 | Journal of Materials Science1979，，7： | 1 |
| 9 | A review on pharmacological and phytochemical properties of Zingiber offtcinale Roscoe (Zingiberaceae) 显示文摘 | Gaurav Kumar L Karthik K V Bhaskara Rao | 2011 | Jour-nal of Pharmacy Research2011，4，9： | 1 |
| 10 | Intermittent hy- poxia effect on osteoclastogenesis stimulated by neuroblasto- ma cells 显示文摘 | Bhaskara VK Mohanam I Gujrati M | 2014 | PLoS One2014，9，10： | 1 |
| 11 | On generalized inverses of Boolean matnces显示文摘 | Prasada Rao P S S N V Bhaskara Rao KPS | 1975 | Linear Algebra andIts Applications1975，11，： | 1 |
| 12 | The theory of generalized inverses over commutative rings显示文摘 | BHASKARA R K P S | 2002 | London:Taylar and Francis2002，，： | 1 |
| 13 | 显示文摘 | Muniyandy Saravanana Kesavan Bhaskara Gomathinayagam Maharajanb | 2004 | International Journal of Pharmaeeutics2004，283，9： | 1 |
| 14 | Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells显示文摘 | Bhaskara VK Mohanam I Rao JS | 2012 | PLoS One2012，7，30： | 1 |
| 15 | Generalized inverse of matrices over integral domains显示文摘 | Bhaskara Rao K P S | 1983 | Linear Algebra Appl1983，49，1： | 1 |
| 16 | A Panel Data Approach to the Demand for Money and the Effects of Financial Reforms in the Asian Countries 显示文摘 | B Bhaskara Rao Saten Kumar | 2009 | Economic Modeling2009，26，5： | 1 |
| 17 | Multicastbased mobility:a novel architecture for efficient micromobility显示文摘 | Jaseemuddin M Bhaskara G | 2004 | IEEE Journal on Selected Areas in Communications2004，22，4： | 1 |
| 18 | A characterization of the permanent function by the Binet-Cauchy theorem显示文摘 | Heuvers K J Cummings L J Bhaskara Rao K P S | 1988 | Linear Algebra and Its Applications1988，101，： | 1 |
| 19 | Characterization and use of essential oil from thymus vulgaris aganm st Botrytis cinerea and Rhizopus stolonifer in strawberry fruits 显示文摘 | Bhaskara R V Paul A Andre G | 1998 | Phytochemistry1998，47，8： | 1 |
| 20 | Reference pointbased multi-objective optimization using evolutionary al- gorithms 显示文摘 | Deb K Sundar J Udaya Bhaskara Rao N | 2006 | International Journal of Computational Intel- ligence Research2006，2，3： | 1 |
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