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| 1 | 子宫内膜异位症患者自然周期卵泡液中细胞因子研究显示文摘目的观察子宫内膜异位症(EMs)患者自然周期卵泡液中细胞因子的表达情况,探讨其与EMs的相关性。方法收集2013~2016年间在瑞士伯尔尼大学妇女医院生殖中心因EMs行自然周期IVF-ET或卵胞浆内单精子注射(ICSI)助孕治疗的17例患者为研究对象(EMs组),其中轻度EMs患者7例,中重度EMs患者10例。同时收集同期17例年龄匹配,因输卵管因素或男方因素在该中心行自然周期IVF/ICSI-ET助孕的患者做为对照组。在自然周期采卵日收集卵泡液,通过Bio-Plex技术检测卵泡液中白介素(IL)-1β、IL-6、IL-8、IL-15、IL-18、调节活化正常T细胞表达与分泌的趋化因子(RANTES)、肿瘤坏死因子(TNF)-α、血管内皮生长因子(VEGF)、白血病抑制因子(LIF)等9种细胞因子的浓度;ELISA法检测单核细胞趋化因子-1(MCP-1)和瘦素(Leptin)的浓度,分析两组间细胞因子浓度的差异及其与EMs的相关性。结果IL-1β和IL-6在EMs患者卵泡液中的浓度显著高于对照组(中位数比较分别为0.8pg/mlvs.0pg/ml和9.1pg/mlvs.6.1pg/ml,P均<0.05)。中重度EMs患者卵泡液中IL-1β浓度(1.44pg/ml)显著高于轻度EMs及对照组(分别为0.26pg/ml、0pg/ml),VEGF浓度(2464pg/ml)亦显著高于轻度EMs及对照组(分别为1268pg/ml、1560pg/ml,P均<0.05)。通过Spearman相关分析发现卵泡液中只有IL-1β和IL-6的浓度与EMs相关,大部分细胞因子相互之间存在较强的相关性。结论EMs患者自然周期卵泡液中细胞因子微环境发生了变化,IL-1β和IL-6的浓度均异常增高,且大部分细胞因子相互之间存在较强的相关性,可能与EMs患者生育力降低有关。 | 吴庚香 Nick Bersinger Michael Mueller Michael von Wolff | 2019 | 生殖医学杂志2019，28，9： | 4 |
| 2 | Women with Preeclampsia Have Increased Serum Levels of Pregnancy‐Associated Plasma Protein A (PAPP‐A), Inhibin A, Activin A and Soluble E‐selectin显示文摘 | Nick A. Bersinger Alexander K. Smárason Shanthi Muttukrishna Nigel P. Groome Christopher W. Redman | 2003 | Hypertension in Pregnancy2003，，1： | 2 |
| 3 | PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis 显示文摘 | Bersinger NA yon Roten S Wunder DM | 2006 | AmJ Obstet Gynecol2006，195，1： | 1 |
| 4 | Women with pre-eclampsia have increased serum levels of pregnancy-associated plasma protein A(PAPP-A),inhibin-A,activin A and soluble Eselectin显示文摘 | Bersinger NA Smarason AK Muttukrish NA | 2003 | Hypertension Pregnancy2003，22，1： | 1 |
| 5 | First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia显示文摘 | Baumann MU Bersinger NA Mohaupt MG | 2008 | Am J Obstet Gynecol2008，199，3： | 1 |
| 6 | Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentra- tions in endometriosis显示文摘 | Scholl B Bersinger NA Kuhn A | 2009 | Gynecol Endocrinol2009，25，11： | 1 |
| 7 | Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for?gestational age pregnancies显示文摘 | Bersinger NA Odegard RA | 2004 | Acta Obstet Gynecol Scand2004，83，1： | 1 |
| 8 | First trimester maternal serum pregnancy associated plasma pretein A and pregnancy specific beta 1-glycoprotein in fetal trisomies显示文摘 | Bersinger NA Brizot ML Johnson A | 2004 | Br J Obstet Gynecol2004，101，： | 1 |
| 9 | Correlation betweensymptoms of pain and peritoneal fluid inflammatory cytokine con-centrations in endometriosis显示文摘 | Scholl B Bersinger NA Kuhn A | 2009 | Gynecol Endocrinol2009，25，11： | 1 |
| 10 | Human placental stem cells: biomedical potential and clinical relevance显示文摘 | Malek A Bersinger NA | 2011 | J Stem Cells2011，6，2： | 1 |
| 11 | Basal and cytokinestimulated production of epithelial neutrophil activating peptide-78(ENA-78) and interleukin-8 (IL-8) by cultured human endometrial epithelial and stromal cells显示文摘 | Bersinger NA Frischknecht F Taylor RN | | 0，，5： | 1 |
| 12 | A sensitive enzyme immunoas-say for pregnancy-associated plasma protein A (PAPP-A):a possible first rimester method of screening for Down syndrome and other trisomies显示文摘 | Bersinger NA | 2005 | Arch Gynecol Obstet2005，256，4： | 1 |
| 13 | PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with en- dometriosis显示文摘 | Bersinger NA von Roten S Wunder DM | 2006 | Am J Obstet Gyneeol2006，195，1： | 1 |
| 14 | Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies 显示文摘 | Bersinger NA θdegard RA | 2004 | Aeta Obstet Gynecol Stand2004，83，： | 1 |
| 15 | Women with pre - ec- lampsia have increased serum levels of pregnancy - associated plas- maprotein A ( PAPP - A), inhibin A, activin A, and soluble E - se- leetin 显示文摘 | Bersinger NA Smaerason AK MRCOG | 2003 | Hypertension Pregnancy2003，22，1： | 1 |
| 16 | Regression of the inflammatory microenvironment of the peritoneal cavity in women with endometriosis by GnRHa treatment 显示文摘 | Nirgianakis K Bersinger NA McKinnon B | 2013 | Eur J Obstet Gynecol Reprod Biol2013，170，2： | 1 |
| 17 | Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A(PAPP-A), inhibin A, activin A and soluble E- selectin显示文摘 | Bersinger N A Smarason A K Muttukrishna S | 2003 | Hypertens Pregnancy2003，22，1： | 1 |
| 18 | Statistically signif- icant changes of antimtillerian hormone and inhibin lev- els during the physiologic menstrual cycle in reproduc- tive age women显示文摘 | Wunder DM Bersinger NA Yared M | 2008 | Fertility dr Sterility2008，89，4： | 1 |
| 19 | First-trimester maternal serum PAPP-A, SPI and M-CSF levels in normal and trisemie twin pregnancies显示文摘 | Bersinger NA Noble P Nicolaldes KH | 2003 | Prenat Diagn2003，23，2： | 1 |
| 20 | Pregnancyassociated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia atterm显示文摘 | Bersinger N A Groome N Muttukrishna S | 2002 | Eur J Endocrinol2002，147，6： | 1 |
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