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| 1 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 2 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 4 | Early closure of a multicenter randomized clinical trial of endoscopic stenting versus surgery for stage IV left-sided colorectal cancer显示文摘 | J. van Hooft P. Fockens A. Marinelli R. Timmer A. van Berkel P. Bossuyt W. Bemelman | 2008 | Endoscopy2008，，03： | 2 |
| 5 | 矿业生产环境改善的生命周期评价显示文摘 | Rene Van Berkel 徐曙光 | 2005 | 国土资源情报2005，，5： | 2 |
| 6 | A randomized trial of endoscopic balloon dilation and endoscopic sphincterotomy for removal of bile duct stones in patients with a prior Billroth II gastrectomy显示文摘 | Jacques J.G.H.M Bergman Anne-Marie van Berkel Marco J Bruno Paul Fockens Erik A.J Rauws Jan G.P Tijssen Guido N.J Tytgat Kees Huibregtse | 2001 | Gastrointestinal Endoscopy2001，，1： | 2 |
| 7 | Interleukins in atherosclerosis:molecular pathway sand therapertic potential显示文摘 | Von der Thusen JH Kuiper J van Berkel TJ | 2003 | Pharmacol Rev2003，55，1： | 1 |
| 8 | Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock显示文摘 | Van Amersfoort ES Van Berkel TJ Kuiper J | 2003 | Ctin Microbiol Rev2003，16，3： | 1 |
| 9 | Free insulin-like growth factor 1 and breast cancer risk显示文摘 | Li BD Khosravi MJ Berkel HJ | 2001 | Int J Cancer2001，91，5： | 1 |
| 10 | Mechanism of hyperoxia - indeuced chromosomal breakage in Chinese hamstet cells 显示文摘 | Gille J van Berkel C Joenje H | 1993 | Environ Mol Mutagen1993，22，： | 1 |
| 11 | A randomized trial of endoscopic balloon dilation and endoscopic sphineterotomy for removal of bile duet stones in patients with a prior Billroth Ⅱ gastrectomy 显示文摘 | Bergman JJ van Berkel AM Bruno M J | 2001 | Gastrointest Endosc2001，53，1： | 1 |
| 12 | lnterIeukins in ather oscler o2sis: molecular pathways and therapeutic potential显示文摘 | Vonder Thusen jH Kui per J van Berkel TJ | 2003 | Phar macol Rev2003，55，13： | 1 |
| 13 | In vivo regulation of scavenger receptor B I and the selective uptake of high density lipoprotein cholesteryl esters in rat liver parenchymal and Kupffer cells显示文摘 | Fluiter K van der Westhui jzen DR van Berkel TJ | 1998 | J Biol Chem1998，273，14： | 1 |
| 14 | Large scale production of recombinant human lactoferrin in the milk of transgenic cows 显示文摘 | VAN BERKEL P H WELLING M M GEERTS M | 2002 | Nat Biotechnol2002，20，5： | 1 |
| 15 | Novel peptides with tyrosinase inhibitory activity 显示文摘 | Marloes S Willem J H van Berkel Harry J W | 2007 | Peptides2007，28，3： | 1 |
| 16 | Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma显示文摘 | Puar T van Berkel A Gotthardt M | 2016 | J Clin Endocrinol Metab2016，101，1： | 1 |
| 17 | Journal of Chromatography B显示文摘 | Berkel J J B N V Dallinga J W Moller G M Godschalk R W L Moonen E Wouters E F M Schoolen F J V | 2008 | 861 : 1012008，861，： | 1 |
| 18 | Randomised trial of endo- scopic balloon dilation versus endoscopic sphineterotomy for re- moval of bileduct stones显示文摘 | Bergman JJ Van Berkel AM Groen AK | 1997 | Lancet1997，349，9059： | 1 |
| 19 | Preconditioning by toll like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia /reperfusion injury显示文摘 | Mersmann J Berkels R Zacharowski P | 2010 | Crit Care Med2010，38，3： | 1 |
| 20 | Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice显示文摘 | von der ThusenJH van Berkel TJ Biessen EA | 2001 | Circulation2001，103，8： | 1 |
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