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| 1 | Transarterial chemoembolization and bland embolization for hepatocellular carcinoma显示文摘Transarterial chemoembolization(TACE)is the first line treatment for patients with intermediate stage hepatocellular carcinoma but is also increasingly being used for patients on the transplant waiting list to prevent further tumor growth.Despite its widespread use,TACE remains an unstandardized procedure,with variation in type and size of embolizing particles,type and dose of chemotherapy and interval between therapies.Existing evidence from randomized controlled trials suggest that bland transarterial embolization(TAE)has the same efficacy with TACE.In the current article,we review the use of TACE and TAE for hepatocellular carcinoma and we focus on the evidence for their use. | Emmanuel A Tsochatzis Evangelia Fatourou James O'Beirne Tim Meyer Andrew K Burroughs | 2014 | World Journal of Gastroenterology2014，20，12： | 18 |
| 2 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 3 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 4 | Role of self-expanding metal stents in the management ofvariceal haemorrhage:Hype or hope?显示文摘Despite the advances of medical,endoscopic and radiological therapy over recent years the mortality rates of acute variceal haemorrhage are still 16%-20% and the medium term outcome has not improved in the last 25 years. Early transjugular intrahepatic portosystemic shunt has proved to be an effective therapy for selected groups of patients with a high risk of re-bleeding and moderate liver disease. However,there is an unmet need for a therapy that can be applied in patients with a high risk of re-bleeding and advanced liver disease either as definitive therapy or as a bridge to permanent therapy. Selfexpanding metal stents can be placed without the need for endoscopic or fluoroscopic control and,once in place,will provide effective haemostasis and allow a route for oral fluids and nutrition. They can remain in place whilst liver function recovers and secondary prophylaxis is initiated. We review the results of 6 case series including a total of 83 patients and the first randomised controlled trial of self-expanding metal stents vs balloon tamponade(BT) in the management of refractory variceal haemorrhage. We report that self-expanding metal stents provide effective haemostasis and perform better than BT in refractory bleeding,where they are associated with fewer complications. Whilst the most effective place for self-expanding metal stents in the management algorithm needs to be determined by further randomised controlled trials,currently they provide an effective alternative to BT in selected patients. | Brian J Hogan James P O’Beirne | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，1： | 5 |
| 5 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 3 |
| 6 | Laryngeal Mask Airways Have a Lower Risk of Airway Complications Compared With Endotracheal Intubation: A Systematic Review显示文摘 | Seung H. Yu O. Ross Beirne | 2010 | Journal of Oral and Maxillofacial Surgery2010，，10： | 2 |
| 7 | Continued evidence for safety of endoscopic retrograde cholangiopancreatography during pregnancy显示文摘AIM: To report the safety of continued use of endoscopic retrograde cholangiopancreatography(ERCP) during pregnancy at various maternal ages.METHODS: A retrospective chart review of pregnant patients who underwent ERCP at a tertiary academic center was undertaken between 2002 and 2012. Pertinent past medical history and initial presenting laboratory data were collected. Review of the procedure note for each ERCP performed provided documentation of lead shielding, type of sedation, fluoroscopy time, and post-procedure complications. Patients' clinical courses were reviewed until the time of delivery and pregnancy complications with fetal outcomes were examined. Data was stratified based upon the mother's age at the time of ERCP: 18-21, 22-29, and ≥ 30 years of age.RESULTS: Twenty pregnant patients who underwent ERCP between 2002 and 2012 were identified. The mean age at the time of ERCP was 26.4 years(18-38 years) and the average trimester was the second. The indications for ERCP were choledocholithiasis in 17 patients, gallstone pancreatitis in 2 patients, and cholangitis in 1 patient. The mean fluoroscopy time of ERCP was 3.8 min(0.3-23.6 min). Sphincterotomy was performed in 18 patients with therapeutic intent and not as a prophylactic measure to prevent recurrences. Clinical documentation of use of protective shielding was found in only 8 notes(40%). Post procedure complications were limited to two cases of post-ERCP pancreatitis(10%). Elective cholecystectomy was performed shortly after ERCP in 11 of the pregnant patients. Birth records were available for 16 patients, of which 15 had fullterm pregnancies. Cesarean sections were performed in 5(31%) patients. Term birth weight was greater than 2500 g in all cases except one in which the mother had a known hypercoagulable state. CONCLUSION: ERCP during pregnancy is both safe and efficacious regardless of maternal age or trimester. | Sean Fine Joshua Beirne Silvia Delgi-Esposti Fadlallah Habr | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 2 |
| 8 | Radionuclide bone imaging for detection of mandibular invasion by squamous cell carcinoma 显示文摘 | Lewis-Jones HG Rogers SN Beirne JC | 2000 | Br J Radiol2000，73，869： | 1 |
| 9 | Laryngeal mask airways have a lower risk of airway complications compared with endotracheal intubation: a systematic review 显示文摘 | Yu SH Beirne OR | 2010 | J Oral Maxillofae Surg2010，68，10： | 1 |
| 10 | Major field study compares pipeline SCC with coatings显示文摘 | O Beirne J | 1992 | Oil Gas Journal1992，90，24： | 1 |
| 11 | Laryngeal mask airways have 'a lower risk of airway complications compared with endotrdcheal intubation:A systematic review显示文摘 | Yu SH Beirne OR | 2010 | J Oral Maxillofac Surg2010，68，10： | 1 |
| 12 | Laryngeal mask airways have a lower risk of airway complications compared with endotracheal intubation: a systematic review 显示文摘 | YU S H BEIRNE O R | 2010 | J Oral Maxillofac Surg2010，68，10： | 1 |
| 13 | Surgical management of patients on warfarin sodium显示文摘 | Beirne OR Koehler JR | 1996 | J Oral Maxillofac Surg1996，54，9： | 1 |
| 14 | Chemical basis of anti-listerial effects of rosemary herb during stomaching with fresh-cut vegetables显示文摘 | Johann Scollard Gillian A. Francis David O’Beirne | 2014 | LWT - Food Science and Technology2014，，： | 1 |
| 15 | Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy显示文摘 | Aymer Postgate Edward Despott David Burling Arun Gupta Robin Phillips James O’Beirne David Patch Chris Fraser | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 16 | Test-retest reliability of motor evoked potentials (MEPs) at the submental muscle group du- ring volitional swallowing 显示文摘 | Doeltgen SH Ridding MC O'Beirne GA | 2009 | J Neurosci Methods2009，178，1： | 1 |
| 17 | Quality of Shredded Carrots as Affected by Packaging Film and Storage Temperature显示文摘 | RYANBARRY C PACUSSI J M O'BEIRNE D | 2000 | J Food Sci2000，65，4： | 1 |
| 18 | Global and regional spillovers in emerging stock markets: A multivariate GARCH-in-mean analysis显示文摘 | John Beirne Guglielmo Maria Caporale Marianne Schulze-Ghattas Nicola Spagnolo | 2010 | Emerging Markets Review2010，，3： | 1 |
| 19 | Oxidative stability of ca- mellia oil in salad dressings, mayonnaises and during frying显示文摘 | Deirdre N1 Eidhin David O'Beirne | 2010 | International Journal o{ Food Science and Technology2010，，45： | 1 |
| 20 | Survival of hydroxyapatite-coated implants:a meta-analytic review显示文摘 | Lee J J Rouhfar L Beirne O R | 2000 | Journal of Oral and Maxillofacial Surgery2000，58，12： | 1 |
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