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| 1 | Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats显示文摘AIM To explore the exact interaction between Notch and transforming growth factor(TGF)-β signaling in liver fibrosis. METHODS We established a rat model of liver fibrosis induced by concanavalin A. Peripheral blood mononuclear cells(PBMCs) were isolated from the modeled rats, and cultured with γ-secretase inhibitor DAPT and TGF-β inhibitor for 24 h. The m RNA levels of Notch and TGF-β signaling were detected by quantitative real-time polymerase chain reaction. Expression of Notch and TGF-β proteins was analyzed by western blotting.RESULTS Compared to control rats, Notch and TGF-β signaling was activated in PBMCs of model rats. Administration of DAPT and TGF-β inhibitor suppressed Notch and TGF-β signal transducer in PBMCs of model rats. DAPT reduced m RNA and protein expression of TGF-β signaling, such as TGF-β1 and Smad3. TGF-β inhibitor also downregulated Notch1, Hes1 and Hes5, and m RNA and protein expression of the Notch signaling pathway.CONCLUSION Notch and TGF-β signaling play a role in liver fibrosis. TGF-β signaling upregulates Notch signaling, which promotes TGF-β signaling. | Yi Wang Ruo-Wu Shen Bing Han Zhen Li Le Xiong Feng-Yu Zhang Bei-Bei Cong Bei Zhang | 2017 | World Journal of Gastroenterology2017，23，13： | 25 |
| 2 | Detection of YMDD.mutants using universal template real-time PCR显示文摘瞄准:与长期的肝炎 B 感染在病人在 lamivudine 治疗期间在肝炎 B 和 lamivudine 抵抗的监视器为 lamivudine 抵抗的变化的察觉建立一个快速、精确的方法。方法:我们用一个通用模板和 TaqMan 探查建立了一个即时 PCR 方法检测 YMDD 异种。YVDD 和 YIDD 的变体被单个反应测试(反应 V 和反应我) 并且全部的肝炎 B 为控制(反应 C ) 在另一反应被检测。结果被 deltaCt <
决定 3.5 (反应 V 的 deltaCt = Ct 或我 - 反应 C 的 Ct ) 。包含不同 YMDD 变化的 HBV 聚合酶基因的克隆被测试。从有长期的肝炎 B 感染的 163 个对待 lamivudine 的病人的浆液样品用这个方法被检测,结果被定序的 DNA 证实。结果:同样多每宽类型的原生质标志的毫升象 1000 个拷贝一样被检测,非特定的 priming 被排除。在从与 lamivudine 对待的病人的 163 件样品, lamivudine 抵抗的变化在 51 件样品被检测。结论:这通用即时 PCR 是为在对待 lamivudine 的病人的 HBV 病毒的 YMDD 异种的数量化离子的一个快速、精确的方法并且能被用来监视 lamivudine 抵抗的变化在前并且在 lamivudine 治疗期间。 | Rong-Sheng Wang Hua Zhang Yu-Fen Zhu Bei Han Zhi-Jun Yang | 2006 | World Journal of Gastroenterology2006，12，8： | 17 |
| 3 | Recent developments of large diameter X80 UOE line pipes显示文摘High-strength pipeline steel and large diameter line pipes are often used to increase the capacity of transportation and reduce the cost associated with the construction and operation of long-distance gas pipeline projects. China's initiatives to construct long-distance natural gas pipelines has brought in new opportunities for the development of X80 line pipes. Baosteel has designed the optimum chemical composition of X80 with high niobium and low molybdenum content. In addition,a welding experimental platform and a finite element model(FEM) have supported the development of X80 UOE pipes in an efficient and economical way. The application and recent development of X80 UOE pipes were introduced in this paper. To comply with the requirements of the Second West-East Gas Pipeline Project(2ndWEPP),X80 pipeline steel with low carbon bainite microstructure was developed by utilizing the optimized composition and TMCP process. The matching welding material,welding procedure and UOE forming processes for 1219mm outside diameter X80 UOE pipes were also developed. More than 340000 t of X80 UOE pipes were produced and applied in the 2ndWEPP. Furthermore,to meet the prospective demand for long-distance gas pipelines with an annual transportation capacity of over 40 billion m3,larger size X80UOE pipes with 1 422 mm OD × 30. 8 mm WT were trial produced recently. DWTT performance,the main technical challenge for heavier wall pipes,was improved by using optimized microstructural design. The newly developed X80 pipes can be potentially used for larger transportation capacity pipelines in China. | ZHANG Chuanguo ZHENG Lei XIE Shiqiang ZHANG Bei HAN Jianzeng QIAN Weifang | 2014 | Baosteel Technical Research2014，8，2： | 9 |
| 4 | Dislocations-induced precipitates and their effect on mechanical properties of Mg-Gd-Y-Zr alloy显示文摘Optical microscope(OM),scanning electron microscope(SEM),transmission electron microscope(TEM)and tensile machine were used to characterize the microstructures and mechanical properties of as-forged and aged Mg-9.5Gd-3.8Y-0.6Zr alloys.The results show that a novel kind of dislocation arrays,comprising parallel arranged dislocations,were obtained in the forged alloy.The arrays tend to extend parallel and are heterogeneously distributed with adjacent distances varying from 0.3μm to 1.4μm.After aging the alloy at 265°C,a large number of preferential-oriented phases were precipitated on the dislocation arrays,forming a structure of'precipitation chains'(PCs),which results in simultaneous increments of strength and ductility. | Chao You Churning Liu Yingchun Wan Bei Tang Bizheng Wang Yonghao Gao Xiuzhu Han | 2019 | Journal of Magnesium and Alloys2019，7，3： | 8 |
| 5 | Small interference RNA targeting vascular endothelial growth factor gene effectively attenuates retinal neovascularization in mice model显示文摘 | KONG Yi-chun SUN Bei ZHAO Kan-xing HAN Mei WANG Yu-chuan | 2013 | Chinese Medical Journal2013，，8： | 7 |
| 6 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 7 | microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout I显示文摘 | Shuang Han Yi-Chun Kong Bei Sun Quan-Hong Han Ying Chen Yu-ChuanWang | 2016 | Chinese Medical Journal2016，，6： | 6 |
| 8 | Hemosuccus pancreaticus:a rare cause of gastrointestinal bleeding显示文摘BACKGROUND: Hemosuccus pancreaticus (HP) is defined as upper gastrointestinal (GI) hemorrhage from the papilla of Vater via the pancreatic duct and is a rare cause of digestive bleeding. DATA SOURCE: A PubMed search of relevant articles published from January 1967 to September 2011 was performed to identify current information about HP in terms of its etiology, pathophysiology, clinical presentation, diagnosis and management. RESULTS: A variety of etiological factors, most commonly chronic pancreatitis but also tumors and vascular diseases, can lead to this condition. Appropriate endoscopic or radiologic procedures should be chosen to establish a precise diagnosis for patients, especially those with a known history of pancreatic disorders, who present with abdominal pain, GI hemorrhage and hyperamylasemia. There are two main therapeutic options for this condition: angiographic embolotherapy and surgery. Both treatments can stop bleeding, but angiographic embolotherapy is the treatment of choice for stable patients. Recently, new and less invasive treatments have emerged to treat this condition. CONCLUSIONS: Because of its rarity and broad spectrum of causes, HP is difficult to diagnose accurately. However, appropriate endoscopic and radiologic procedures are extremely helpful for establishing a correct diagnosis. Both angiographic embolotherapy and surgery are reliable treatment options for this condition, and transcatheter intervention is the treatment of choice for clinically stable patients. Additional innovative treatments have emerged, but their effectiveness and safety must be confirmed. | Han, Bing Song, Zeng-Fu Sun, Bei | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 4 |
| 9 | Biological characters of [^18F]O-FEt-PIB in a rat model of Alzheimer's disease using micro-PET imaging显示文摘瞄准:评估是否最新综合的正电子排放断层摄影术( PE T )示踪器,[ 18F ]2-(4'-(甲基amino )苯基) -6-fluoroethoxy-benzothiazole([18F]O-FEt-PIB),could 用micro-PET.Method:在 Alzheimer 的疾病(广告)的一个老鼠模型绑在贝它淀粉的总数[ 18F ] O-FEt-PIB 被收音机 HPLC.PET 成像综合并且净化在 3 模型和 3 控制与一台 R4 啮齿类动物模型扫描仪被执行老鼠。动态宠物扫描在跟随约 37 MBq 的注射的每只老鼠为 40 min 被执行[18F ] O-FEt-PIB.Static 扫描也被执行因为在每个 rat.PET 数据的 15 min 被一个最大的后验概率算法重建。在花冠宠物图象上,兴趣的区域分别地被放在外皮上,半大脑[包括马头鱼尾的怪兽和丘脑( HT )],并且被 3-D 指导老鼠大脑的数字地图或大脑图象[ 18F ] 2-Deoxy-2-fluoro-D-glucose ([ 18F ] FDG )在正常rats.Time活动,曲线( TAC )为大脑和小脑被获得。在 2 个半大脑之间的活动差别价值(副词) 也是 calculated.Results : TAC 为[18F ] 在大脑或小脑的 O-FEt-PIB 早达到顶点(在约 2 min ) ,但是有点慢慢地外面洗了。在里面动态、静态微 -- 宠物图象,在灌输了与的地方,增加的放射性在模型老鼠在正确 HT 的区域被发现贝它淀粉(1-40 ) 。放射性的不同差别都没在控制老鼠在正确、左的 HT 区域之间被发现。ADV_( HT )在 AD 模型老鼠和比控制老鼠(3.9%)的大的约 4 次是约14.6% .Conclusion :到我们的知识,这研究是第一为P淀粉的存款在活体内评估一根小分子的宠物探针用微--在一只注射广告的老鼠的宠物成像当模特儿。合适的生物人物证明示踪器有潜力为在广告检测 P 淀粉的匾作为一根探针被发展。 | Ming-qiang ZHENG Duan-zhi YIN Lan ZHANG Bei LEI Deng-feng CHENG Han-cheng CAI Yan-jiang HAN Ming-xing WU Hong ZHANG Jing WANG | 2008 | Acta Pharmacologica Sinica2008，29，5： | 4 |
| 10 | Quality of terrestrial data derived from UAV photogrammetry:A case study of Hetao irrigation district in northern China显示文摘Most crops in northern China are irrigated,but the topography affects the water use,soil erosion,runoff and yields.Technologies for collecting high-resolution topographic data are essential for adequately assessing these effects.Ground surveys and techniques of light detection and ranging have good accuracy,but data acquisition can be time-consuming and expensive for large catchments.Recent rapid technological development has provided new,flexible,high-resolution methods for collecting topographic data,such as photogrammetry using unmanned aerial vehicles(UAVs).The accuracy of UAV photogrammetry for generating high-resolution Digital Elevation Model(DEM)and for determining the width of irrigation channels,however,has not been assessed.A fixed-wing UAV was used for collecting high-resolution(0.15 m)topographic data for the Hetao irrigation district,the third largest irrigation district in China.112 ground checkpoints(GCPs)were surveyed by using a real-time kinematic global positioning system to evaluate the accuracy of the DEMs and channel widths.A comparison of manually measured channel widths with the widths derived from the DEMs indicated that the DEM-derived widths had vertical and horizontal root mean square errors of 13.0 and 7.9 cm,respectively.UAV photogrammetric data can thus be used for land surveying,digital mapping,calculating channel capacity,monitoring crops,and predicting yields,with the advantages of economy,speed and ease. | Hongming Zhang Jiangtao Yang Jantiene E.M.Baartman Shuqin Li Bei Jin Wenting Han Xiaomei Yang Lingtong Gai Coen J.Ritsema Violette Geissen | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 4 |
| 11 | Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome: The Effect of Body Mass Index and Geographic Distribution显示文摘Genetic,lifestyle,and environmental factors contribute to the etiology of polycystic ovary syndrome(PCOS).Increased body mass index(BMI)exacerbates the reproductive and metabolic parameters and reduces the fecundity of women with PCOS.This is a secondary analysis of a large-sample,multicenter,randomized controlled trial conducted at 21 sites in Chinese mainland.A total of 1000 women diagnosed with PCOS were enrolled in this trial.Of these,998 women with PCOS were included in the analysis.Increased BMI was associated with more severe menstrual irregularities,elevated testosterone level,higher prevalence of metabolic syndrome,and poorer quality of life.The rates of ovulation per woman for the normal,overweight,and obese BMI groups were 83.0%,78.2%,and 63.6%,respectively(P<0.001),and the rates of live birth were 23.6%,18.1%,and 15.3%(P=0.030).Northern PCOS patients showed more severe reproductive,glucose,and lipid profiles;less exercise;and lower total ovulation rates compared with PCOS patients from Southern China(74.8%vs 81.2%,absolute difference 6.4%,95%confidence interval 1.2%–11.5%).The results show the typical phenotypic features of Han women with PCOS in Northern and Southern China.The women living in Northern China showed a higher BMI,more severe glycolipid metabolism profiles,and subsequently worse clinical outcomes by the same interventions than those living in Southern China.The difference in phenotypic features can be explained mostly by differences in BMI and the resulting difference in ovulation. | Jingshu Gao Hongli Ma Yu Wang Xinming Yang Yijuan Cao Bei Zhang Conghui Han Xiaoke Wua | 2021 | Engineering2021，7，2： | 3 |
| 12 | Two New Iridoid Glucosides from Clerodendrum serratum显示文摘Two new iridoid glucosides, serratoside A and serratoside B, were isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Their structures were elucidated by spectral and chemical methods. | Hui YANG Bei JIANG Zhi NA Yun Pin GUO Han Dong SUN | 2000 | Chinese Chemical Letters2000，11，3： | 2 |
| 13 | A New Phenolic Compound from Thamnolia vermicularis显示文摘A new phenolic compound, thamnolin (1), was isolated from the extract of Thamnolia vermicularis. Its structure was determined as 6-tricosyl-2,4-dimethoxy-phenol by spectral methods. | Bei JIANG, Shuang Xi MEI, Quan Bin HAN, Wei XIANG, Han Dong SUN* Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2001 | Chinese Chemical Letters2001，12，1： | 2 |
| 14 | Evaluation and prediction of slope stability using machine learning approaches显示文摘In this paper,the machine learning(ML)model is built for slope stability evaluation and meets the high precision and rapidity requirements in slope engineering.Different ML methods for the factor of safety(FOS)prediction are studied and compared hoping to make the best use of the large variety of existing statistical and ML regression methods collected.The data set of this study includes six characteristics,namely unit weight,cohesion,internal friction angle,slope angle,slope height,and pore water pressure ratio.The whole ML model is primarily divided into data preprocessing,outlier processing,and model evaluation.In the data preprocessing,the duplicated data are first removed,then the outliers are filtered by the LocalOutlierFactor method and finally,the data are standardized.11 ML methods are evaluated for their ability to learn the FOS based on different input parameter combinations.By analyzing the evaluation indicators R2,MAE,and MSE of these methods,SVM,GBR,and Bagging are considered to be the best regression methods.The performance and reliability of the nonlinear regression method are slightly better than that of the linear regression method.Also,the SVM-poly method is used to analyze the susceptibility of slope parameters. | Shan LIN Hong ZHENG Chao HAN Bei HAN Wei LI | 2021 | Frontiers of Structural and Civil Engineering2021，15，4： | 2 |
| 15 | Modeling the transport of TiO 2 nanoparticle aggregates in saturated and unsaturated granular media: Effects of ionic strength and pH显示文摘 | Jing Fang Mei-jia Xu Deng-jun Wang Bei Wen Jing-yi Han | 2012 | Water Research2012，，： | 2 |
| 16 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 17 | Expression of human leukocyte an- tigen G is associated with prognosis in nasopharyngeal carcinoma 显示文摘 | Cai MB Han HQ Bei JX | 2012 | Int J Bio Sci2012，8，6： | 1 |
| 18 | Significant Polymorphisms of Vitamin D Receptor Gene(rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area显示文摘Type 2 diabetes mellitus (T2DM) accounts for 90% of all diabetes cases and results in severe complications. It is a multifactorial metabolic disorder that results from a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The interaction between multiple genetic and environmental determinants has been considered to contribute to the pathogenesis of T2DM[1]. | HAN Han ZHAO Ming Xu WANG Yan WANG Jun REN Bing Nan GE Hui Na WANG Teng SUN Bei Bei BA Yue LI Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，1： | 1 |
| 19 | Microbio- logical safety and quality of commercial sufu and Chinese fermented soybean food 显示文摘 | Han Bei zhong Rijkelt R Rombouts Frans M | 2001 | Food Control2001，，12： | 1 |
| 20 | Crystal and Molecular Structure of an Inclusion Complex of p-tert-Butylcalix[6]arene with Toluene显示文摘IntroductionInthepastfewyears,thecalixareneshaveparticularlyatractedatentionfromresearcherswhohavebeenworkingonhost-guestcomp... | LU Tong bu, LI Xiao yan and JI Liang nian ** (Department of Chemistry and Center of Measurement, Zhongshan University, Guangzhou, 510275) HAN Bao hang and LIU Yu (Department of Chemistry, Nankai University, Tianjin, 300071) YU Kai bei (Ch | 1999 | Chemical Research in Chinese Universities1999，15，1： | 1 |
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