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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Industrial Ultrafiltration Design and Application of Diafihration process显示文摘 | Beaton N C Klinkowski P R | 1983 | Separ Proc Technol1983，4，2： | 1 |
| 3 | A study compared nine patient - specific indices for musculoskeletal disorders 显示文摘 | Jolles BM Buchbinder R Beaton DE | 2005 | J Clin Epidemiol2005，58，： | 1 |
| 4 | Exposure to duty-related in cident stressors in urban firefighters and paramedics显示文摘 | Beaton R Murphy S Johnson C | 1998 | J Trauma Stress1998，11，4： | 1 |
| 5 | Looking back at design,looking forward to construction显示文摘 | BROWN C D BEATON H R | 1990 | Journal of Management in Engineering1990，6，3： | 1 |
| 6 | Measuring worker productivity : frameworks and measures 显示文摘 | BEATON D BOMBARDIER C ESCORPIZO R | 2009 | J Rheumatol2009，36，9： | 1 |
| 7 | A synthesis of aldosterone acetate显示文摘 | Barton H R Beaton J M | 1960 | J Am Chem Soc1960，82，10： | 1 |
| 8 | Reaction of bone to multiple metallic implants 显示文摘 | Bothe R T Beaton L E Davenport H A | 1940 | Surg Gynecol Obstet1940，71，： | 1 |
| 9 | A study compared nine patient-specific indices for museuloskeletal disorders显示文摘 | Jolles BM Buchbinder R Beaton DE | 2005 | J Clin Epidemiol2005，58，8： | 1 |
| 10 | Plant response to sulfur in Western Canada 显示文摘 | Beaton J D Soper R J | 1986 | Agric Agronomy1986，27，： | 1 |
| 11 | Suppression of β -casein gene expression by inhibition of protein synthesis in mouse mammary epithelial cells is associated with stimulation of NF - KB activity and blockage of prolactin - Stats signaling显示文摘 | Beaton A Marita K Broadhurst R J | 2003 | Cell Tissue Res2003，311，： | 1 |
| 12 | 显示文摘 | Bertolacini R | 1991 | Catal Rev-Sci Eng1991，34，34： | 1 |
| 13 | Sulphur--a vital component of maximum economic yield systems显示文摘 | Beaton J D Wagner R E | 1985 | Sulphur in Agriculture1985，9，： | 1 |
| 14 | Dynamic full-scale tests median barrier 显示文摘 | Beaton J L Field R N | 1960 | HRB Bull1960，266，1： | 1 |
| 15 | Associations of exogenous DNA with cattle and insect spermatozoa in vitro显示文摘 | Atkinson P W Hines E R Beaton S | 1991 | Mol Reprod1991，29，： | 1 |
| 16 | Coping responses and posttraumaticstress symptomatology in urban fire service personnel显示文摘 | Beaton R Murphy S | 1999 | Traum Stress1999，12，2： | 1 |
| 17 | Disaster nursing curriculum development based on vulnerability assessment in the pacific northwest显示文摘 | Bond E F Beaton R | 2005 | Nurs Clin North Am2005，40，3： | 1 |
| 18 | Associa-tion of exoigenous DNA with cattle and insect sper-matozoa in vitro显示文摘 | Atkinson P W Hines E R Beaton S | 1991 | Mol Reprod1991，29，1： | 1 |
| 19 | Randomized trial of an in- ternet-bascd computer-tailored expert system for physical activity in patients with heart disease显示文摘 | Reid R D Morrin L I Beaton L J | 2012 | Eur J Prey Cardiol2012，19，6： | 1 |
| 20 | Validity of observerbasedaggregate scoring symtems as descriptors of elbow pain,function anddisability显示文摘 | Turchin D C Beaton D E Richards R R | 1998 | J bone Surg(Am)1998，80，： | 1 |
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