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| 1 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 2 | 定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域显示文摘尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其交互作用时,自然便产生对临床药理学的协同作用。创新性和可塑性训练计划和策略均是将来临床研究工作中必不可少的要素。掌握定量药理学领域的知识成为对药理科学家的要求,具有定量药理学背景的人员可望获得更高的薪水。目前定量药理学相关培训计划,教学资料,及学术权威均比较贫乏,学生们可以从企业化、调控性的背景的教师等多种机构的教职员那获得指导,此外也可以通过在线课程,可视化教学进修课程,与他们的导师保持联系。对课程和学位的管理可以采取灵活的态度,这样可在短期内培养更多的定量药理学工作者。 | Jeffrey S Barrett Michael J Fossler K.David Cadieu Marc R Gastonguay 沈杰 谢海棠 孙瑞元 | 2008 | 中国临床药理学与治疗学2008，13，5： | 10 |
| 3 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 4 | Optimal soil conservation and the reform of agricultural price policies 显示文摘 | Barrett S | 1991 | Journal of Development Economics1991，，2： | 2 |
| 5 | Development of a European herbage growth model(the EU Grazemore project)显示文摘 | Barrett P D Mayne A S | 2004 | Grassland Science in Europe2004，9，： | 1 |
| 6 | The Epidemiology of Peste des Petits Ruminants in the Sultanate of Oman显示文摘 | TAYLOR W P ALBUSAIDY S BARRETT T | 1990 | Vet Microbiol1990，22，4： | 1 |
| 7 | Modulating chemokines:more lessons from viruses显示文摘 | LALANI A S BARRETT J W MCFADDEN G | 2000 | Immunol Today2000，21，2： | 1 |
| 8 | A randomised multicentre trial显示文摘 | Saunders M Dische S Barrett A et aL Continuous hyperfractionaed accelerated radiotherapy(CHART)versus conventional radiotherapy in non-small-cell lung cancer | 1997 | Lancet1997，350，9072： | 1 |
| 9 | Type 2 diabetes mellitus in UK children-an emerging problem显示文摘 | EHTISHAM S BARRETT TG SHAW NJ | 2000 | Diabet Med2000，17，12： | 1 |
| 10 | Bovine congenital erythrocytic protoporphyria in a Limousin calf bred in the UK 显示文摘 | Armstrong S C Jonsson N N Barrett D C | 2002 | Vet Rec2002，19，： | 1 |
| 11 | Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression显示文摘 | Dupont J Dunn S E Barrett J C | 2003 | Recent Prog Horm Res2003，58，： | 1 |
| 12 | Using weather in- dex insurance to improve drought response for famine preven- tion 显示文摘 | Chantarat S Barrett C B Mude A G | 2007 | American Journal of Agricultural Economics2007，89，5： | 1 |
| 13 | Fracture Intensity Distributions during Compression of Puffed Corn Meal Extrudates-Method for Quantifying Fracturability显示文摘 | Barrett A H Rosenberg S Ross E W | | 0，，3： | 1 |
| 14 | Shotcrete Support Design in Blocky Ground: Towards A Deterministic Approach显示文摘 | Barrett S V L McCreath D R | 1995 | Tunnelling and Underground Space Technology1995，10，1： | 1 |
| 15 | Interaction of electrons with grain boundaries 显示文摘 | Cohen M H Barrett C S | 1954 | Physical Review1954，95，4： | 1 |
| 16 | Genome-wide associationdefines more than 30 distinct susceptibility loci for Crohn's disease显示文摘 | Barrett JC Hansoul S Nicolae DL | 2008 | Nat Genet2008，40，8： | 1 |
| 17 | GrazeGro: a European herbage growth model to predict pasture production in perennial ryegrass swards for decision support 显示文摘 | Barrett P D Laidlaw A S Mayne C S | 2005 | European Journal of Agronomy2005，1，： | 1 |
| 18 | The evolution of plant sexual diversity显示文摘 | Barrett S C H | 2002 | Nature Reviews Genetics2002，3，： | 1 |
| 19 | Live p robiotics p rotect intestinal ep ithelial cells from the effects of infection with entenroinvasive escherichiacoil(EIEC)显示文摘 | Rests-Lenert S Barrett KE | 2003 | Gut2003，52，7： | 1 |
| 20 | The comparative biology of pollination and mating in flowering plants 显示文摘 | BARRETT S C H HARDER L D WORLEY A C | 1996 | Philosophical Transactions of the Royal Society B1996，351，1329： | 1 |
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