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| 1 | Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?显示文摘AIM To clarify which factors may influence pathological tumor response and affect clinical outcomes in patients with locally advanced rectal carcinoma treated with neo-adjuvant chemoradiotherapy and surgery.METHODS Tumor regression grade(TRG) according to the Dworak system and yT NM stage were assessed and correlated with pre-treatment clinico-pathological variables in 215 clinically locally advanced(c TNM stage Ⅱ and Ⅲ) rectal carcinomas. Prognostic value of all pathological and clinical factors on disease free survival(DFS) and cancer specific survival(CSS) was analyzed by Kaplan Meier and Cox-regression analyses.RESULTS cN + status, mucinous histotype or poor differentiation in the pre-treatment biopsy were significantly associated with lower pathological response(low Dworak grade and TNM remaining unchanged/upstaging). Cases showing acellular mucin pools in surgical specimens all had unremarkable clinical courses with no deaths or recurrences during follow-up. Dworak grade had prognostic significance for DFS and CSS. However, compared to the 5-tiered system, a simplified twotiered grading system, in which grades 0, 1 and 2 were grouped as absent/partial regression and grades 3 and 4 were grouped as total/subtotal regression, was more reproducible and prognostically informative. The twotiered Dworak system, yN stage, craniocaudal extension of the tumor and radial margin status were significant independent prognostic variables. CONCLUSION Our data suggest that caution should be applied in using a conservative approach in rectal carcinomas with c N+ status, extensive/lower involvement of the rectum and mucinous histotype or poor differentiation. Although Dworak TRG is prognostically significant, a simplified two-tiered system could be preferable. Finally, cases with acellular mucin pools should be carefully evaluated to definitely exclude residual mucinous carcinoma. | Luca Reggiani Bonetti Simona Lionti Federica Domati Valeria Barresi | 2017 | World Journal of Gastroenterology2017，23，8： | 7 |
| 2 | Cell-block procedure in endoscopic ultrasound-guided-fine-needle-aspiration of gastrointestinal solid neoplastic lesions显示文摘In the present review we have analyzed the clinical applications of endoscopic ultrasound-guided-fineneedle-aspiration(EUS-FNA) and the methodological aspects obtained by cell-block procedure(CBP) in the diagnostic approach to the gastrointestinal neoplastic pathology. CBP showed numerous advantages in comparison to the cytologic routine smears; in particular, better preservation of cell architecture, achievement of routine haematoxylin-eosin staining equivalent to histological slides and possibility to perform immunohistochemistry or molecular analyses represented the most evident reasons to choose this method. Moreover, by this approach, the differential diagnosis of solid gastrointestinal neoplasias may be more easily achieved and the background of contaminant nonneoplastic gastrointestinal avoided. Finally, biological samples collected by EUS-FNA CBP-assisted should be investigated in order to identify and quantify further potential molecular markers. | Antonio Ieni Valeria Barresi Paolo Todaro Rosario Alberto Caruso Giovanni Tuccari | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，11： | 6 |
| 3 | Endoscopic treatment of biliary complications after liver transplantation显示文摘AIM:To evaluate the efficacy of endoscopic treatment in patients who undergo OLTx or LRLTx and develop biliary complications. METHODS:This is a prospective, observational study of patients who developed biliary complications, after OLTx and LRLTx, with duct-to-duct anastomosis performed between June 2003 and June 2007. Endoscopic Retrograde Cholangiopancreatography (ERCP) was considered unsuccessful when there was evidence of continuous bile leakage despite endoscopic stent placement, or persistence of stenosis after 1 year, despite multiple dilatation and stent placement. When the ERCP failed, a percutaneous trans-hepatic approach (PTC) or surgery was adopted. RESULTS: From June 2003 to June 2007, 261 adult patients were transplanted in our institute, 68 from living donors and 193 from cadaveric donors. In the OLTx group the rate of complications was 37.3%, while in the LRLTx group was 64.7%. The rate of ERCP failure was 19.4% in the OLTx group and 38.6% in LRLTx group. In OLTx group, 1 patient was re- transplanted and 8 patients died. In the LRLTx group, 2 patients underwent OLTx and 8 patients died. The follow-up was 23.3 ± 13.13 mo and 21.02 ± 14.10 mo, respectively.CONCLUSION: Although ERCP is quite an effective mode of managing post-transplant bile duct complications, a significant number of patients need other types of approach. Further prospective studies are necessary in order to establish whether other endoscopic protocols or new devices, could improve the current results. | Ilaria Tarantino Luca Barresi Ioannis Petridis Riccardo Volpes Mario Traina Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，26： | 6 |
| 4 | 胰腺的膀胱的损害: 内视镜的超声形态学和内视镜的超声罚款针渴望帮助怎么开诊断难题显示文摘 Cystic lesions of the pancreas are being diagnosed with increasing frequency,covering a vast spectrum from benign to malignant and invasive lesions.Numerous investigations can be done to discriminate between benign and non-evolutive lesions from those that require surgery.At the moment,there is no single test that will allow a correct diagnosis in all cases.Endoscopic ultrasound(EUS) morphology,cyst fluid analysis and cytohistology with EUS-guided fine needle aspiration can aid in this difficult diagnosis. | Luca Barresi Ilaria Tarantino Antonino Granata Gabriele Curcio Mario Traina | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 5 |
| 5 | Phagocytosis(cannibalism) of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas显示文摘AIM:To identify those with a micropapillary pattern,ascertain relative frequency and document clinicopathological characteristics by reviewing gastric carcinomas.METHODS:One hundred and fifty-one patients diagnosed with gastric cancer who underwent gastrectomy were retrospectively studied and the presence of a regional invasive micropapillary component was evaluated by light microscopy.All available hematoxylin-eosin(HE)-stained slides were histologically reviewed and 5 tumors were selected as putative micropapillary carcinoma when cancer cell clusters without a vascular core within empty lymphatic-like space comprised at least5%of the tumor.Tumor tissues from these 5 invasive gastric carcinomas were immunostained using an antimucin 1(MUC1)antibody(clone MA695)to detect the characteristic inside-out pattern and with D2-40antibody to determine the presence of intratumoral lymph vessels.Detection of intraepithelial neutrophil apoptosis was evaluated in consecutive histological tissue sections by three independent methods,namely light microscopy with HE staining,the conventional terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end-labeling(TUNEL)method and immunohistochemistry for activated caspase-3(clone C92-605).RESULTS:Among 151 gastric cancers resected for cure,5(3.3%)were adenocarcinomas with a micropapillary component.Four of the patients died of disease from 6 to 23 mo and one patient was alive with metastases at 9 mo.All patients had advanced-stage cancer(≥p T2)and lymph node metastasis.Positive MUC1 immunostaining on the stroma-facing surface(inside-out pattern)of the carcinomatous cluster cells,together with negative immunostaining for D2-40 in the cells limiting lymphatic-like spaces,confirmed the true micropapillary pattern in these gastric neoplasms.In all five cases,several micropapillae were infiltrated by neutrophils.HE staining,TUNEL assay and immunostaining for caspase-3 demonstrated apoptoticneutrophils within cytoplasmic vacuoles of tumor cells.These data suggest phagocytosis(cannibalism)of apoptotic neutrophils by micropapillary tumor cells.Tumor cell cannibalism is usually found in aggressive tumors with anaplastic morphology.Our data extend these observations to gastric micropapillary carcinoma:a tumor histotype analogously characterized by aggressive behavior and poor prognosis.The results are of interest because they raise the intriguing possibility that neutrophil cannibalism by tumor cells may be one of the mechanisms favoring tumor growth in gastric micropapillary carcinomas.CONCLUSION:This is the first study showing phagocytosis(cannibalism)of apoptotic neutrophils by tumor cells in gastric micropapillary carcinomas. | Valeria Barresi Giovanni Branca Antonio Ieni Luciana Rigoli Giovanni Tuccari Rosario Alberto Caruso | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 6 | Interventional endoscopic ultrasound:Therapeutic capability and potential显示文摘The linear echoendoscope,introduced in the 1990s,opened the era of interventional endoscopic ultrasound(IEUS).The linear echoendoscope enabled EUS guided Fine Needle Aspiration(EUS-FNA) allowing the path of the needle to be traced during the puncture process.After EUS-FNA,other interventional procedures were introduced in clinical practice.Tissue acquisition was the first EUS-guided interventional procedure and its higher diagnostic quality has undoubtedly been established.After EUS-FNA,Celiac plexus neurolysis(CPN) and block(CPB),pancreatic pseudocyst drainage,abdominal and mediastinal collections/abscesses drainage,and in selected cases,pancreatic and biliary ductal system drainage,were introduced in clinical practice.EUS-guided fine needle injection with local delivery of antitumor agents is considered a promising modality.We have reviewed published data on EUS guided interventional procedures with the object of summarizing the diagnostic capability of endoscopic ultrasound and elaborates in detail its therapeutic capability and potential. | Ilaria Tarantino Luca Barresi | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 4 |
| 7 | Endoscopic ultrasound-guided fine-needle aspiration cytology in pancreaticobiliary carcinomas:diagnostic efficacy of cell-block immunocyto-chemistry显示文摘BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration cytology was demonstrated to be a useful tool for the diagnosis and staging of pancreaticobiliary neoplastic lesions.Nonetheless,the diagnostic value of this procedure may be limited by low cellularity of the specimen,contamination of intestinal cells and unfeasibility of ancillary immunocytochemical procedures.The present study was to evaluate its usefulness in the diagnosis of neoplastic lesions.METHODS:A series of 46 pancreaticobiliary carcinomas with available cell block preparations was submitted to immunocytochemistry against cytokeratins,carcinoembryonic antigen,E-cadherin,CD10 and p53.The sensitivity,specificity,positive and negative predictive values of the cytological smear in the discrimination of malignant lesions were calculated and compared with those of cell block preparation with the immunocytochemical stains against p53 and CD10.RESULTS:According to our findings,the use of cell block preparations together with immunostains against p53 and CD10allowed to discriminate malignant versus benign specimens with higher sensitivity than the only cytological examination.In detail,CD10 immunostaining was of significant help for the discrimination between cytological contaminants,such as benign gastrointestinal cells,and the neoplastic elements of pancreaticobiliary well differentiated adenocarcinomas.Also,intense nuclear immunoreactivity for p53 was encountered in about 2/3 of the cases and identified pancreatic malignancy with high sensitivity.CONCLUSIONS:We suggest that immunocytochemistry against both CD10 and p53 could be applied case by case,mainly to differentiate gastrointestinal and pancreatic benign cellular contaminants showing hyperplasia or reactive changes from differentiated pancreaticobiliary adenocarcinomas. | Antonio Ieni Paolo Todaro Stefano Francesco Crinò Valeria Barresi Giovanni Tuccari | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 4 |
| 8 | Simultaneous endoscopic ultrasound fine needle aspiration and endoscopic retrograde cholangio-pancreatography:Evaluation of safety显示文摘AIM: To investigate the rate of complications of endoscopic retrograde cholangio-pancreatography (ERCP) performed immediately after endoscopic ultrasound fine needle aspiration (EUS-FNA) in a large series of patients. METHODS: Patients with the following conditions were considered candidates for EUS-FNA and ERCP: diagnosis of locally advanced or metastatic pancreatic lesion not eligible for surgery, and patients with pancreatic lesion of unknown nature causing jaundice. Data were prospectively collected on the following parameters: indication for FNA, EUS findings, pathological diagnosis, procedure duration of EUS-FNA and combined EUS-FNA and ERCP, and immediate and late complications. RESULTS: From January 2004 to October 2006, 72 patients were deemed eligible for combined EUS and ERCP. In 25/72 EUS-FNA was performed to obtain a pathology diagnosis of lesions causing biliary obstruction, and ERCP sequentially performed to drain the biliary system. No immediate complications occurred except for two mild bleeding episodes post sphincterotomy. No late complications were recorded except for one patient who experienced fever, promptly recovered with antibiotic therapy. CONCLUSION: Simultaneous approach appears to be feasible and safe. When possible, this can be considered the reference standard to avoid double sedation and reduce duration of the procedure and hospital stay. | Ilaria Tarantino Luca Barresi Marta Di Pisa Mario Traina | 2007 | World Journal of Gastroenterology2007，13，28： | 4 |
| 9 | 盖住的自我有为避免 stent 赶出的胰腺的 pseudocyst 的在内的闪耀的塑料的可扩充的金属性的 stent显示文摘 Endoscopic ultrasound-guided drainage has recently been recommended for increasing the drainage rate of endoscopically managed pancreatic fluid collections and decreasing the morbidity associated with conventional endoscopic trans-mural drainage. The type of stent used for endoscopic drainage is currently a major area of interest. A covered self expandable metallic stent (CSEMS) is an alternative to conventional drainage with plastic stents because it offers the option of providing a larger-diameter access fi stula for drainage, and may increase the fi nal success rate. One problem with CSEMS is dislodgement, so a metallic stent with flared or looped ends at both extremities may be the best option. An 85-year-old woman with severe comorbidity was treated with percutaneous approach for a large (20 cm) pancreatic pseudocyst with corpuscolated material inside. This approach failed. The patient was transferred to our institute for EUS-guided transmural drainage. EUS confi rmed a large, anechoic cyst with hyperechoic material inside. Because the cyst was large and contained mixed and corpusculated fluid, we used a metallic stent for drainage. To avoid migration of the stent and potential mucosal growth above the stent, a plastic prosthesis (7 cm, 10 Fr) with flaps at the tips was inserted inside the CSEMS. Two months later an esophagogastroduodenoscopy was done, and showed patency of the SEMS and plastic stents, which were then removed with a polypectomy snare. The patient experienced no further problems. | Ilaria Tarantino Marta Di Pisa Luca Barresi Gabriele Curcio Antonino Granata Mario Traina | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，4： | 3 |
| 10 | Endoscopic ultrasound guided biliary drainage显示文摘Endoscopic retrograde cholangio-pancreatography is the most appropriate technique for treating common bile duct and pancreatic duct stenosis secondary to benign and malignant diseases. Even if the procedure is performed by skillful endoscopist, there are patients in whom endoscopic stent placement is not possible. Common causes of failure include complex peripapillary diverticula, prior surgery procedures, tumor involvement of the papilla, biliary sphincter stenosis, and impacted stones. Percutaneous trans-hepatic biliary drainage (PTBD) and surgical intervention carry morbidity and mortality. Recently endoscopic ultrasonography-guided biliary drainage has been reported as an alternative technique. Endoscopic ultrasonography- guided biliary drainage using either direct access or a rendezvous technique has attracted attention as an alternative procedure to PTBD, with a technical success between 75%-100% and with low complication rate. We have reviewed published data on EUS guided biliary drainage procedures with the aim of summarizing the efficacy and safety of this promising method. | Ilaria Tarantino Luca Barresi Carlo Fabbri Mario Traina | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 3 |
| 11 | Tulip bundle technique and fibrin glue injection:Unusual treatment of colonic perforation显示文摘We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two endoloops.Finally we chose to use a fibrin glue injection to obtain a complete sealing.Four days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in situ.Inspection of the sigma showed complete repair of the perforation.This report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon. | Filippo Mocciaro Gabriele Curcio Ilaria Tarantino Luca Barresi Marco Spada Sergio Li Petri Mario Traina | 2011 | World Journal of Gastroenterology2011，17，8： | 2 |
| 12 | Variceal bleeding from ileum identified and treated by single balloon enteroscopy显示文摘We report a case of acute uncontrolled gastrointestinal bleeding in a patient with liver cirrhosis.The upper and lower endoscopy were negative for bleeding lesions. We decided to perform the examination of the small bowel using single-balloon enteroscopy.The lower enteroscopy revealed signs of bleeding from varices of the ileum.In this report,we showed that the injection of a sclerosant solution can be accomplished using a freehand technique via the single balloon enteroscopy. | Mario Traina Ilaria Tarantino Luca Barresi Filippo Mocciaro | 2009 | World Journal of Gastroenterology2009，15，15： | 2 |
| 13 | Development of simplified models for the freeze-drying process and investigation of optimal operating conditions显示文摘 | Velardi S A Barresi A A | 2008 | Chemical Engineering Research and Design2008，86，1： | 1 |
| 14 | Placement of covered self-expandable metal biliary stent for the treatment of severe postsphincterotomy bleeding:outcomes of two cases显示文摘 | Di Pisa M Tarantino I Barresi L | | 0，，： | 1 |
| 15 | Telomere instability in pa- pillary bladder urothelial carcinonms: Comparison with grading and risk of recurrence显示文摘 | Mucciardi G Gali'A Barresi V | 2014 | IndianJUrol2014，30，3： | 1 |
| 16 | Flocculation of asphaltenes in heavy oil at elevated temperatures显示文摘 | Storm D Barresi R J Sheu E | 1996 | Fuel Science & Tech- nology International1996，14，12： | 1 |
| 17 | Vestibular paroxysmia : diagnos- tic features and medical treatment 显示文摘 | Hufner K Barresi D Glaser M | 2008 | Neurology2008，71，13： | 1 |
| 18 | Bioassay-guided isolation of antiproliferative compounds from grape(Vitis vinifera)stems显示文摘 | Amico V Barresi RV Chiliemi DF | 2009 | Nat Prod Commum2009，4，1： | 1 |
| 19 | Analysis of the UK diagnostic strategy for limb girdle muscular dystrophy 2A 显示文摘 | Groen E J Charlton R Barresi R | 2007 | Brain2007，130，12： | 1 |
| 20 | Laparoscopic adrenalectomy 显示文摘 | Barresi RV Prinz RA | 1999 | Arch Surg1999，134，2： | 1 |
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