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| 1 | 炎症反应与药物治疗在脑动脉瘤治疗中的作用(英文)显示文摘Intracranial aneurysms remain important clinical concern. There is relatively low risk of rupture of symptomless aneurysms incidentally found in MRA or CTA performed due to other indications. Not all of the intracranial aneurysms should or can be treated with neurosurgery intervention or endovascular embolization. Clinical strategy for small, symptomless, unruptured aneurysms is still questionable. Mechanisms underlying aneurysms formation,progression and rupture are poorly understood. Inflammation is one of the factors suspected to participate in these processes. Therefore the aim of this manuscript is to present current state of knowledge about the role of inflammation in the formation and progression of intracranial aneurysms and in their rupture process. Current knowledge about possible pharmacological treatment of intracranial aneurysms will also be presented. Macrophages infiltration seems to participate in the formation of intracranial aneurysms. Inhibition of signals sent by macrophages may prevent the aneurysms formation. Inflammation present in the wall of the aneurysm seems to be also related to the aneurysm's rupture risk. However it does not seem to be the only cause of the degeneration,but it can be a possible target of drug therapy. Some preliminary studies in humans indicate the potential role of aspirin as a factor that decrease the level of inflammation and lower the risk of rupture of intracranial aneurysms. However further research including a greater number of subjects and a prospective randomized design are necessary to assess the role of aspirin in preventing strategy for small,symptomless,unruptured intracranial aneurysms. | Gruszka W Zbroszczyk M Komenda J Gruszczyńska K Baron J | 2018 | 中华神经外科疾病研究杂志2018，17，5： | 3 |
| 2 | Pancreaticobiliary and duode- nal perforations after periampullary endoscopic proce- dures : diagnosis and management显示文摘 | Fatima J Baron T H Topazian M D Houghton S G Iqbal C W Ott B J | 2007 | Arch Surg2007，142，： | 1 |
| 3 | Molecular Cloning and Characterization of Human and Murine Dnase Ⅱ显示文摘 | Baker K P Baron W F Henzel W J etal | 1998 | Gene1998，215，： | 1 |
| 4 | Suport for linkage of familial combined hyperlipidemia to chromosome1q21-q23 in Chinese and German families显示文摘 | Pei W Baron H MμLler-Myhsok B etal | 2000 | Clin Genet2000，57，1： | 1 |
| 5 | PDGF and FGF-2 signaling in oligodendrocyte progenitor cells:regulation of proliferation and differentiation by multiple intracellular signaling pathways显示文摘 | Baron W Metz B Bansal R | 2000 | Mol Cell Neurosci2000，15，3： | 1 |
| 6 | Forced convective condensation in tubes: A heat transfer correlation for condenser design显示文摘 | Traviss D P Rohsenow W M Baron A B | 1973 | ASHRAE Transactions1973，79，1： | 1 |
| 7 | Biomolecular modelling: goals, problems, perspectives 显示文摘 | Van Gunsteren W F Bakowies D Baron R | 2006 | Angew Chem Int Ed Eng2006，45，： | 1 |
| 8 | lh'amipexole for the treatment of depres- sive symptoms in patients with Parkinson's disease: a random- ised, double-blind, placebo-controlled trial 显示文摘 | Barone P Poewe W | 2010 | Lancet Neurol2010，9，6： | 1 |
| 9 | Rescue of recombinant peste des petits ruminants virus: crea- tion of a GFP-expressing virus and application in rapid virus neutralization test显示文摘 | Hu Q Chen W Huang K Baron M D Bu Z | 2012 | Vet Res2012，1，2： | 1 |
| 10 | Review of analytical techniques for arson residues显示文摘 | Pert A D Baron M G BirkeR J W | 2006 | Journal of Forensic Science2006，51，5： | 1 |
| 11 | Measures of agreement between computation and experiment : validation metrics 显示文摘 | Oberkampf W L Barone M F | 2006 | Journal of Computational Physics2006，217，1： | 1 |
| 12 | An investigation of dust generation by free falling powders显示文摘 | BARON P A WILLEKE K | 1992 | American Industrial Hygiene Association1992，53，10： | 1 |
| 13 | Maternal exposure to neighborhood carbon monoxide and risk of low birth weight 显示文摘 | ALDERMAN B W BARON A E SAVITZ D A | 1987 | Public Health Report1987，102，： | 1 |
| 14 | Regulation of integrin growth factor interactions in oligodendrocytes by lipid raft microdomains 显示文摘 | Baron W Decker L Colognato H | 2003 | Curr Biol2003，13，： | 1 |
| 15 | Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families显示文摘 | Pei W Baron H Müller-Myhsok B | 2000 | Clin Genet2000，57，： | 1 |
| 16 | Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data显示文摘 | Magerl W Krumova EK Baron R | 2010 | Pain2010，151，3： | 1 |
| 17 | Neuron-specific enolase increases in cerebral and systemic circulation following focal ischemia显示文摘 | CLARK R K PRICE W J | 1993 | Brain Res1993，623，1： | 1 |
| 18 | Neuron--specific enolase increase in cerebral and systemtic circulation fallowing focal ischemia显示文摘 | BARONE F CLARK R PRICE w | 1993 | Brain Res1993，623，1： | 1 |
| 19 | Lessons learned while compiling a quantitative exposure database from the published literature 显示文摘 | CALDWELL D J ARMSTRONG T W BARONE N J etal | 2001 | Appl Occup Environ Hyg2001，16，2： | 1 |
| 20 | Compounding and molding of polyethylene composites reinforced with keratin feather fiber显示文摘 | Barone J R Schmidt W F Liebner C F E | 2005 | Composites Science and Technology2005，65，34： | 1 |
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