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| 1 | lsolation of cells from ovine fetal long bone and characterization of their osteoblastic antivities during in vitro mineralization显示文摘 | Collignon H Davicco M J Barlet J P | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 2 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco MJ Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 3 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco MJ Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 4 | lsolation of cells from oxine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco MJ Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 5 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco M J Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 6 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco M J Barlet J P | 1997 | Arch PhysiolBiochem1997，105，2： | 1 |
| 7 | FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer显示文摘AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.METHODS This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and safety.RESULTS Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the 'irinotecan-na?ve' patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the 'pre-exposed irinotecan' patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), respectively.CONCLUSION Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept. | CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel | 2018 | World Journal of Clinical Oncology2018，9，5： | 1 |
| 8 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization 显示文摘 | Collignon H Davicco M J Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 9 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization 显示文摘 | Collignon H Davicco M J Barlet J P | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 10 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Colliguon H Davicco MJ Barlet JP | 1997 | Arch Physiol Biochcm1997，105，2： | 1 |
| 11 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | COLLIGNON H DAVICCO M J BARLET J P | 1997 | Arch Physiod Biochem1997，105，： | 1 |
| 12 | Recent devdopments on the analysis and optimum design of sheet metal forming parts using a simplified inverse approach 显示文摘 | Y Q Guo J L Batoz H Naceur S Bouabdallah F Mercier O Barlet | 2000 | Computers and Structures 782000，，： | 1 |
| 13 | Recent developments on the analysis and optimum design of sheet metal forming parts using a simplified inverse approach 显示文摘 | Guo Y Q Batoz J L Naceur H Bouabdallah F Mercier F Barlet O | 2000 | Computers and Structures2000，78，： | 1 |
| 14 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | COLLIGNON H DAVICCO M J BARLET J P | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 15 | Isolation of cells from ovine fetal long bone and characterization显示文摘 | Collignon H Davicco MJ Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 16 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization 显示文摘 | Collignon H Davieco MJ Barlet JP | 1997 | Archives of physiology and bio- chemistry1997，105，2： | 1 |
| 17 | Mechanism of propofol bradycardia 显示文摘 | Colson P Barlet H Roquefeuill B | 1988 | Anesth Analg1988，67，9： | 1 |
| 18 | Isolation of cells from bovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco MJ Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 19 | Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization 显示文摘 | Collignon H Davicco M J Barlet JP | 1997 | Arch Physiol Biochem1997，105，2： | 1 |
| 20 | Isolation of cellsfrom ovine fetal long bone and characterization of theirosteoblastic activities during in vitro mineralization显示文摘 | Collignon H Davicco MJ Barlet JP | 1997 | ArchPhysiol Biochem1997，105，2： | 1 |
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