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| 1 | Predicting(side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics显示文摘Inflammatory bowel disease (IBD) is a chronic and heterogeneous intestinal inflammatory disorder. The medical management of IBD aims for long-lasting disease remission to prevent complications and disease progression. Early introduction of immunosuppression forms the mainstay of medical IBD management. Large inter-individual variability in drug responses, in terms of both efficacy and toxicity, leads to high rates of therapeutic failure in the management of IBD. Better patient stratification is needed to maximize patient benefit and minimize the harm caused by adverse events. Pre-treatment pharmacogenetic testing has the potential to optimize drug selection and dose, and to minimize harm caused by adverse drug reactions. In addition, optimizing the use of cheap conventional drugs, and avoiding expensive ineffective drugs, will lead to a significant reduction in costs. Genetic variation in both TPMT and NUDT15, genes involved in thiopurine metabolism, is associated to an increased risk of thiopurine-induced myelosuppression. Moreover, specific HLA haplotypes confer risk to thiopurine-induced pancreatitis and to immunogenicity to tumor necrosis factor-antagonists, respectively. Falling costs and increased availability of genetic tests allow for the incorporation of pre-treatment genetic tests into clinical IBD management guidelines. In this paper, we review clinically useful pharmacogenetic associations for individualized treatment of patients with IBD and discuss the path from identification of a predictive pharmacogenetic marker to implementation into IBD clinical care. | Michiel Dirk Voskuil Amber Bangma Rinse Karel Weersma Eleonora Anna Margaretha Festen | 2019 | World Journal of Gastroenterology2019，25，21： | 2 |
| 2 | Prostate-specific antigen-based prostate cancer screening:reduction of prostate cancer mortality after correction for nonattendance and contamination in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer显示文摘 | Bokhorst L P Bangma C H van Leenders G J | 2014 | Eur Urol2014，65，2： | 1 |
| 3 | Human xenografi mod- els as useful tools to assess the potential of novel therapeutics in prostate cancer显示文摘 | Van Weerden WM Bangma C De Wit R | 2009 | Bri J Cancer2009，100，1： | 1 |
| 4 | Diagnosis and management of seminal vesicle cysts associated with ipsilateral renal agenesis: a pooled analysis of 52 cases显示文摘 | Van den Ouden VD Blom JH Bangma C | 1998 | Eur Urol1998，33，5： | 1 |
| 5 | Novel tools to improve patient selection and monitoring on active surveillance for low-risk prostate cancer: a systematic review显示文摘 | VAN DEN BERGH RC AHMED HU BANGMA CH | 2014 | Eur Urol2014，65，6： | 1 |
| 6 | The value of (-7,-5 ) pro-prostate-specific antigen and human kallikrein-2 as serum markers for grading prostate cancer 显示文摘 | Bangma CH Wildhagen MF Yurdakul G | 2004 | BJU Int2004，93，6： | 1 |
| 7 | Active surveillance for prostate cancer: a systematic review of the literature显示文摘 | Dall' Era MA Albertsen PC Bangma C | 2012 | Eur Urol2012，62，6： | 1 |
| 8 | The value of EZH2,p27(kip1),BMI-1 and MIB-1 on biopsy specimens with low-risk prostate cancer in selecting men with significant prostate cancer at prostatectomy显示文摘 | Wolters T Vissers K J Bangma CH | 2010 | BJU Int2010，106，2： | 1 |
| 9 | Algorithms based on prostatespecific antigen (PSA),free PSA,digital rectal examination and prostate volume reduce false-positive PSA results in prostate cancer screening显示文摘 | Finne P Finne R Bangma C | | 0，，02： | 1 |
| 10 | Diagnosis and management of seminal vesicle cysts associated with ipsilateral renalagenesis:a pooled analysis of 52 cases显示文摘 | van den Ouden D Blom JH Bangma C | 1998 | Eur Urol1998，33，5： | 1 |
| 11 | Crystals cause acute necrotic cell death in renal proximal tubule cells,but not in collecting tubule cells显示文摘 | Schepers MS van Ballegooijen ES Bangma CH | 2005 | Kidney Int2005，68，4： | 1 |
| 12 | Prostate specific antigen in a community-based sample of men without prostate cancer:correlations with prostate volume,age,body mass index,and symptoms of prostatism显示文摘 | Bosch J L Hop W C Bangma C H | 1995 | Prostate1995，27，5： | 1 |
| 13 | Diagnosis and management of seminal vesicle cysts associated with ipsilateral renal agenesis : a pooled analysis of 52 cases 显示文摘 | Van den Ouden D Blom JH Bangma C | 1998 | Eur Urol1998，33，5： | 1 |
| 14 | The Free-to-Total Serum Prostate Specific Antigen Ratio for Staging Prostate Carcinoma显示文摘 | Chris H. Bangma Ries Kranse Bert G. Blijenberg Fritz H. Schroder | 1997 | The Journal of Urology1997，，2： | 1 |
| 15 | Diagnosis and management of seminal vesicle cysts associated with ipsilateral renalagenesis:a pooled analysis of 52 cases显示文摘 | Van den Ouden D Blom JH Bangma C et a1 | | 0，，05： | 1 |
| 16 | Outcomes of a bladder cancer screening program using home hematuria testing and molecular markers显示文摘 | Bangma CH Loeb S Busstra M | 2013 | Eur Urol2013，64，： | 1 |
| 17 | Adenovirus-mediated interleukin-12 gene therapy for prostate cancer:suppression of orthotopic tumor growth and pre established lung metastases in an orthotopic model 显示文摘 | Nasu Y Bangma CH Hull GW | 1999 | Gene Ther1999，6，3： | 1 |
| 18 | Immunotherapy for superficial bladder cancer显示文摘 | Ellen A. M. Schenk-Braat Chris H. Bangma | 2005 | Cancer Immunology Immunotherapy2005，，5： | 1 |
| 19 | Diagnosis and management of seminal vesicle cysts associated with ipsilateral renal agenesis: a pooled analysis of 52 cases显示文摘 | van den Ouden D Biota JH Bangma C | 1998 | Ear Urol1998，33，5： | 1 |
| 20 | Comparison of two assays for human kallikrein 2显示文摘 | Blijenberg B G Wildhagen M F Bangma C H | 2003 | Clin Chem2003，49，： | 1 |
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