|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Pyrolytic conversion of methyland vinylsilane polymers to Si-C ceramics 显示文摘 | HURWITZ F I KACIK T A BU X Y | 1995 | J Mater Sci1995，30，： | 2 |
| 4 | Some sufficient conditions for a planar graph of maximum degree six to be class 1显示文摘 | BU Y WANG W | 2006 | Discrete Math2006，306，13： | 1 |
| 5 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 6 | Diazoxide prevents diabetes throughinhibiting pancreatic beta-cells from apoptosis via Bc- l 2/ Baxrate and p38 -beta mitogen-activated protein kinase显示文摘 | Huang Q Bu S Yu Y | 2007 | Endocri-nology2007，148，1： | 1 |
| 7 | Community-wide germination strategies in an alpine meadow on the eastern Qinghai-Tibet Plateau:phylogenetic and life-history correlates显示文摘 | Bu H Y Du G Z Chen X L | 2008 | Plant Ecology2008，195，1： | 1 |
| 8 | Topological structure analysis of the protein-protein interaction network in budding yeast 显示文摘 | Bu D Zhao Y Cai L | 2003 | Nucleic Acids Research2003，31，9： | 1 |
| 9 | Mutant DNA-binding domain of HSF4is associated with autosomal dominant lamellar and Marner cataract显示文摘 | Bu L Jin Y Shi Y | 2002 | Nat Genet2002，31，： | 1 |
| 10 | NFBD1/MDC1 is a protein of oncogenie potential in human cervical cancer 显示文摘 | Yuan C Bu Y Wang C | 2012 | Mol Cell Biochem2012，359，： | 1 |
| 11 | Seed size and germination in an alpine meadow on the eastern Qinghai-Tibet plateau显示文摘 | Bu H Y Chen X L Xu X L | 2007 | Plant Ecology2007，191，： | 1 |
| 12 | Anti-coagulation effect of Fc fragment against anti-βz-GP 1 antibodies in mouse models with APS显示文摘 | Xie W Zhang Y Bu C | 2010 | lnt Immunophamacol2010，11，： | 1 |
| 13 | Diazoxide prevents diabetes through inhibiting pancreatic Beta- cells from apoptosis via Bcl-2/Bax Rate and p38-beta mitogen-activated protein kinase显示文摘 | Huang Q Bu S Yu Y | 2007 | Endocrinology2007，148，1： | 1 |
| 14 | Rural - urban disparities of breast cancerpatients in China 显示文摘 | Zhang Y Bu Y Gao H | 2013 | Med Oncol2013，30，1： | 1 |
| 15 | Antidiabetic effect of ginsengoside Rb3 in alloxan-induced diabetic mice 显示文摘 | BU Q T ZHANG W Y CHEN Q C et a l | 2012 | Med Chem2012，8，5： | 1 |
| 16 | Synthesis of Porous NiO/Reduced Graphene Oxide Composites for Supercapacitors显示文摘 | Bu Y F Wang S Jin H L | | 0，，： | 1 |
| 17 | Using the LANDIS model to evaluate forest harvesting and planting strategies under possible warming climates in Northeaster显示文摘 | Bu R C He H S Hu Y M | 2008 | Forest Ecology and Management2008，254，： | 1 |
| 18 | Co-delivery of IL-2 or liposomes augment the responses of mice to a DNA vaccine for pseudorabies virus IE180显示文摘 | J Bu Y Song G Rompato D.J Burgess A.E Garmendia | 2002 | Comparative Immunology Microbiology and Infectious Diseases2002，，3： | 1 |
| 19 | Representations for the Drazin inverses of the sum of two matrices and some block matrices显示文摘 | Bu C J Feng C C Bai S Y | 2012 | Appl Math Comput2012，218，10： | 1 |
| 20 | Dual effects of nitric oxide on meiotic maturation of mouse cumulus cell- enclosed ooeytes in vitro 显示文摘 | BU S XIA G TAO Y | 2003 | Mol Cell Endocrinol2003，207，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员