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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 3 | Loss of Halophytism by Interference with SOS1 Expression1[W][OA]显示文摘 | Oh Dong-Ha Leidi Eduardo Zhang Quan Hwang Sung-Min Li Youzhi Quintero Francisco J Jiang Xingyu D’Urzo Matilde Paino Lee Sang Yeol Zhao Yanxiu Bahk Jeong Dong Bressan Ray A Yun Dae-Jin Pardo José M Bohnert Hans J | 2009 | Plant Physiology2009，，1： | 1 |
| 4 | Tissue-specific activation of the osmotin gene by ABA, C2H4 and NaCl involves the same promoter region显示文摘 | K. G. Raghothama Albino Maggio Meena L. Narasimhan Andrzej K. Kononowicz Guangli Wang Matilde Paino D’Urzo Paul M. Hasegawa Ray A. Bressan | 1997 | Plant Molecular Biology1997，，3： | 1 |
| 5 | Mi- croRNAs couple cell fate and developmental timing in ret- ina显示文摘 | DECEMBRINI S BRESSAN D VIGNALI R | 2009 | Proc Natl Acad Sci USA2009，106，21： | 1 |
| 6 | Spatial and temporal changes of type VI collagen expression during mouse de- velopment显示文摘 | Marvulli D Volpin D Bressan GM | 1996 | Dev Dyn1996，206，4： | 1 |
| 7 | TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome显示文摘 | McDERMOTT D A BRESSAN M C HE J | 2005 | Pediatr Res2005，58，： | 1 |
| 8 | Metabolic changes associated with adaptation of plant cells to water stress显示文摘 | HANDA S BRESSAN R A | 1986 | Plant Physiol1986，82，： | 1 |
| 9 | Dissection of floral induction pathways using global expression analysis 显示文摘 | Schmid M Uhlenhaut N H Godard F Demar M Bressan R Weigel D Lohmann J U | 2003 | Development2003，130，： | 1 |
| 10 | Influence of abutment mate- rial on the gingival color of implant - supported all - ceramic res- torations: a prospective muhicenter study 显示文摘 | Bressan E Paniz G Lops D | 2011 | Clin Oral Im- plants Res2011，22，6： | 1 |
| 11 | Pediatric Emergency Care Applied Research Network head injury clinical prediction rules are reliable in practice 显示文摘 | Schonfeld D Bressan S Da Dalt L | 2014 | Arch Dis Child2014，99，5： | 1 |
| 12 | Influence of abutment material on the gingival color of implant-supported all-ceramic restoralions : a prospective multicenter study 显示文摘 | Bressan E Paniz G Lops D | 2011 | Clin Oral Implants Res2011，22，6： | 1 |
| 13 | Modeling of nanoindentation of bulk and thin film by finite element method显示文摘 | Bressan J D Tramontin A C Rosa C | 2005 | Wear2005，258，： | 1 |
| 14 | Influence of abutment material on the gingival colour of implant-supported all-ceramic restorations: a prospective multicenter study 显示文摘 | Bressan E Paniz G Lops D | 2011 | Clin Oral Implants Res2011，22，6： | 1 |
| 15 | Standerdization and interlabo- ratory reproducibilit assessment of plused - field gel electrophoresis -generated fingerprints of Acinetobacter baumannii显示文摘 | Harald S Lucilla D Bressan R | 2005 | J Clin Mi- crobiol2005，43，： | 1 |
| 16 | The Best Men Are(Not Always)Already Taken Female Preference for Single Versus Attached Males Depends on Conception Risk显示文摘 | Bressan P Stranieri D | 2008 | Psychological Science2008，19，2： | 1 |
| 17 | Short implants in partially edentuolous maxillae and mandibles:a 10 to 20 years retrospec- tive evaluation 显示文摘 | Lops D Bressan E Pisoni G | 2012 | lnt J Dent2012，2012，35： | 1 |
| 18 | Abrasive wear behavior of high speed steel and hard metal coated with TiAlN and TiCN显示文摘 | BRESSAN J D HESSE R SILVA E M | 2001 | Wear2001，250，： | 1 |
| 19 | Intracellular conse- quences of SOS1 deficiency during salt stress 显示文摘 | Oh D H Lee S Y Bressan R A | 2010 | Journal of Experimental Botany2010，61，4： | 1 |
| 20 | Ki-1/57 in- teracts with PRMT1 and is a substrate for arginine methylation显示文摘 | Passos D O Bressan G C Nery F C | 2006 | Febs J2006，273，： | 1 |
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