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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Cumulative positive fluid balance is a risk factor for acute kidney injury and requirement for renal replacement therapy after liver transplantation显示文摘AIM To analyze whether fluid overload is an independent risk factor of adverse outcomes after liver transplantation(LT).METHODS One hundred and twenty-one patients submitted to LT were retrospectively evaluated.Data regarding perioperative and postoperative variables previously associated with adverse outcomes after LT were reviewed.Cumulative fluid balance(FB) in the first 12 h and 4 d after surgery were compared with major adverse outcomes after LT.RESULTS Most of the patients were submitted to a liberal approach of fluid administration with a mean cumulative FBover 5 L and 10 L,respectively,in the first 12 h and 4 d after LT.Cumulative FB in 4 d was independently associated with occurrence of both AKI and requirement for renal replacement therapy(RRT)(OR = 2.3;95%CI:1.37-3.86,P = 0.02 and OR = 2.89;95%CI:1.52-5.49,P = 0.001 respectively).Other variables on multivariate analysis associated with AKI and RRT were,respectively,male sex and Acute Physiology and Chronic Health Disease Classification System(APACHE II) levels and sepsis or septic shock.Mortality was shown to be independently related to AST and APACHE II levels(OR = 2.35;95%CI:1.1-5.05,P = 0.02 and 2.63;95%CI:1.0-6.87,P = 0.04 respectively),probably reflecting the degree of graft dysfunction and severity of early postoperative course of LT.No effect of FB on mortality after LT was disclosed.CONCLUSION Cumulative positive FB over 4 d after LT is independently associated with the development of AKI and the requirement of RRT.Survival was not independently related to FB,but to surrogate markers of graft dysfunction and severity of postoperative course of LT. | Liana Codes Ygor Gomes de Souza Ricardo Azevedo Cruz D'Oliveira Jorge Luiz Andrade Bastos Paulo Lisboa Bittencourt | 2018 | World Journal of Transplantation2018，8，2： | 4 |
| 3 | The varia- bility of the apnoea-hypopnoea index 显示文摘 | Bittencourt L R Suchecki D Tufik S | 2001 | J Sleep Res2001，10，3： | 1 |
| 4 | The variability ofthe apnoea-hypopnoea index显示文摘 | Bittencourt LR Suchecki D Tufik S | 2001 | Sleep Res2001，10，3： | 1 |
| 5 | Microbiological assay for enrofloxacin injection 显示文摘 | Souza M J Bittencourt C F Paulo D A | 2004 | Int J Pharma2004，271，： | 1 |
| 6 | Study on the formation of mesoporous molecular sieves in the presence of various anions显示文摘 | Pastore H Munsignatti M Bittencourt D R S | 1999 | Microporous and Mesoporous Materials1999，32，12： | 1 |
| 7 | Therapeutic applications of repetitive transcranial magnetic stimulation in clinical neurorehabilitation显示文摘 | Machado S Bittencourt J Minc D | 2008 | Funct N eurol2008，23，3： | 1 |
| 8 | Fluid dy- namics and thermal aspects of the dewatering of high-alumina re- fractory castables : removal of physically absorbed water 显示文摘 | Innocentini M D M Ribeiro C Bittencourt L R M | 2001 | J Am Ceram Soc2001，84，11： | 1 |
| 9 | Therapeutic ap- plications of repetitive transcranial magnetic stimulation in clinical neurorehabilitation显示文摘 | Machado S Bittencourt J Minc D | 2008 | Functional Neurology2008，23，3： | 1 |
| 10 | Analysis of co-transcriptional RNA processing by RNA-ChIP assay显示文摘 | Bittencourt D Auboeuf D | 2012 | Methods Mol Biol2012，809，： | 1 |
| 11 | Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells显示文摘 | GELAIN D P de BITTENCOURT PASQUALIA M A ZANOTTOFILHO A | 2008 | Chemico-Biological Interactions2008，174，1： | 1 |
| 12 | Influence of polymerization conditions on the molecular weight and polydispersity of polyepichlorohydrin显示文摘 | Guanaes D Bittencourt E Eberlin M N | 2007 | European Polymer Journal2007，43，： | 1 |
| 13 | A method for testing the host specificity of ectoparasites:give them the opportunity to choose显示文摘 | Esbéard CE Martins-Hatano F Bittencourt EB Bossi DE Fontes A Lareschi M Menezes V Bergallo HG Gettinger D | 2005 | Memórias do Instituto Oswaldo Cruz2005，，07： | 1 |
| 14 | 显示文摘 | Quinn P D Bittencourt C Brown D | 2002 | J Phys: Condens Matter2002，14，： | 1 |
| 15 | Plasmapheresis for recurrent posttransplant focal segmental glomerulosclerosis 显示文摘 | GARCIA C D BITTENCOURT V B TUMELERO A | 2006 | Transplant Proc2006，38，6： | 1 |
| 16 | Spidroins from the Brazilian spider Nephilengys cruentata (Araneae: Nephilidae)显示文摘 | BITTENCOURT D SOUTO B M VERZA N C | 2007 | Comp Bioehem Physiol B Biochem Mol Biol2007，147，4： | 1 |
| 17 | 查看详情显示文摘 | Guanaes D Bittencourt E Eberlin M N Sabino A A | | 0，，： | 1 |
| 18 | Retinol increases catalase activity and protein content by a reactive species dependent mechanism in Sertoli cells 显示文摘 | Gelain D P de Bittencourt Pasquali M A Zanotto-Fiho A | 2008 | Chemico-Biological Interactions2008，174，1： | 1 |
| 19 | Tensor LEED and MEIS determination of the Ni(110)c(2×2)-Sn surface structure显示文摘 | QUINN P D BITTENCOURT C BROWN D | 2002 | J Phys:Condens Matter2002，14，： | 1 |
| 20 | Therapeutic applications of repetitive transcranial magnetic stimulation in clinical neurorehabilitation显示文摘 | Machado S Bittencourt J Minc D | | 0，，03： | 1 |
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