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| 1 | 睾酮和良性前列腺增生症显示文摘由于医患双方对于男性迟发性腺功能减退症状的警觉,使得近期针对此类患者的睾酮治疗增多。但是考虑到睾酮治疗对前列腺的影响,尤其可能增加前列腺癌发病风险,促进了该方面的研究进展。出乎意料的是大量的回顾性或小样本随机研究提示睾酮治疗或可改善男性下尿路症状。虽然此改善的确切机理仍在争论中,但或许和代谢综合征密切相关。对于临床医生,这些研究的结果虽然让人期待,但是缺乏高等级证据支持。因此在诊断迟发性腺功能减退症或考虑睾酮治疗前,仍需对患者进行包括病史、体检和睾酮测量在内的全面临床检查。睾酮补充治疗可能导致尿潴留和加重下尿路症状,这些产品说明上标注的风险依然存在,应该在用药前向患者解释说明。 | Thomas R Jarvis Bilal Chughtai Steven A Kaplan | 2015 | Asian Journal of Andrology2015，17，2： | 7 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Role of endoscopic ultrasound in liver disease: Where do we stand in 2017?显示文摘Endoscopic ultrasound(EUS) was first introduced into medical practice in 1980 s as a diagnostic imaging modality for pancreatic pathology. EUS has the unique advantage of combining ultrasound and endoscopy to obtain detailed information of the gastrointestinal tract. Over the past decade, the use of EUS in liver diseases has been increasing. EUS, which was initially used as a diagnostic tool, is now having increasing therapeutic role as well. We provide a review of the application of EUS in the diagnostic and therapeutic aspects of liver disease. We also look at the evolving future research on the role of EUS in liver diseases. | Hamzeh A Saraireh Mohammad Bilal Shailendra Singh | 2017 | World Journal of Hepatology2017，9，24： | 4 |
| 4 | Tube thorocostomy: management and outcome in patients with penetrating chest trauma显示文摘 | Muslim M Bilal A Salim M | 2008 | J Ayub Med Coil Ablmttabad2008，20，4： | 1 |
| 5 | MODENAR: Multi-objective differ- ential evolution algorithm for mining numeric association rules 显示文摘 | BILAL A ERHAN A ALI K | 2008 | Applied Soft Computing2008，8，1： | 1 |
| 6 | Comparison by simulation of energy con-sumption and WSN lifetime and LEACH-SM 显示文摘 | BILAL A LESZEK T | 2014 | Procedia computer science2014，34，： | 1 |
| 7 | Application of factorial design in optimization of ultrasonic - assisted extraction of aluminum in juices and soft drinks 显示文摘 | Nusrat Jalbani Tasnecm G Kazi Bilal M Arain M K Jamali Hassan I Afridi R A Sarfraz | 2006 | Talanta2006，，70： | 1 |
| 8 | A probabilistic fouling and cost model for plate-and-frame heat exchangers显示文摘 | Zubair Bilal A Q | 2006 | Energy Research2006，30，1： | 1 |
| 9 | -Association of nitrogen-fixing, plant-growth-promoting rhizobacteria (PGPR) with kallar grass and rice显示文摘 | Malik K A Bilal R Mehnaz | 1997 | Plant and Soil1997，194，： | 1 |
| 10 | Flight control of a rotary wing UAV using backstepping 显示文摘 | Bilal A Hemanshu P R Matt G | 2010 | International Journal of Robust and Nonlinear Control2010，20，6： | 1 |
| 11 | Microstructure and tensile behavior of a friction stir processed magnesium alloy 显示文摘 | BILAL Mansoor GHOSH A K | 2012 | Acta Mater2012，60，1314： | 1 |
| 12 | Hydrocarbon habitat in main producing areas,Saudi Arabia 显示文摘 | AYRES M BILAL M JONES R W SLENTZ L W TARTIR M WILSON A O | 1982 | AAPG bulletin1982，66，1： | 1 |
| 13 | Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation显示文摘 | Handra-Luca A Bilal H Bertrand J C Fouret P | 2003 | Am J Pathol2003，163，： | 1 |
| 14 | Connective tissue growth factor expression hints at aggressive nature of colorectal cancer显示文摘BACKGROUND Connective tissue growth factor(CTGF)is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling,inflammatory processes and fibrosis in various illnesses including cancer.AIM To investigate the role of CTGF in colorectal cancer(CRC)progression and to compare the CTGF expression with different clinicopathological parameters.METHODS Real-time polymerase chain reaction,immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version 16.RESULTS CTGF expression levels in tumor specimens were significantly higher than their paired normal specimens.The higher protein expression levels showed a significant association with smoking,staging,tumor grade,invasion depth,necrosis of tumor tissue,and both lymphovascular and perineural invasion.As per the cox regression model and classification tree analysis,tumor-nodemetastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC patients.Survival analysis indicated that CTGF overexpression was associated with poorer overall and disease-free survival.CONCLUSION Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC patients.These findings support prior observations and thus CTGF may be a possible prognostic marker in CRC. | Ishrat Parveiz Bhat Tahseen Bilal Rather Irfan Maqbool Gowhar Rashid Kulsum Akhtar Gulzar A Bhat Fazl Q Parray Besina Syed Ishrat Younas Khan Mohsin Kazi Muhammad D Hussain Mudassar Syed | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
| 15 | Multi-criteria selection of electric power plants using the analytic hierarchy process显示文摘 | Rustom Mamlook Mousa S Mohsen | 1999 | Electric Power Systems Research1999，52，： | 1 |
| 16 | Removal of methylene blue from aqueous solution using cotton stalk,cotton waste and cotton dust显示文摘 | Murat Erta(s)a Bilal Acemiǒglub M Hakkl Almaa | | 0，，： | 1 |
| 17 | Assessment of LPG as a Possible Alternative to R-12 in Domestic Refrigerators显示文摘 | BILAL A | 2003 | Energy Conversion Management2003，44，381： | 1 |
| 18 | Allelopathy in agroecosystems: wheat phytotoxicity and its possible roles in crop rotation显示文摘 | Lodhi M A K Bilal R Malik K A | 1987 | Journal of Chemical Ecology1987，13，8： | 1 |
| 19 | Characterization of Azospirillum and relate diazotrophs associated with root of plant growing in saline soils显示文摘 | Bilal R Rasul G Qurshi J A | 1990 | World J of Microbiology and Biotechnology1990，11，6： | 1 |
| 20 | Shoot regeneration and free-radical scavenging activity in Silybum marianum L 显示文摘 | Bilal H A Mubarak A K Tariq M | 2010 | Plant Cell Tiss Organ Cult2010，101，： | 1 |
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