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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Respiro- metry techniques and activated sludge models显示文摘 | BENES O SPANJERS H HOLBA M | 2002 | Water Science and Technology2002，46，45： | 1 |
| 3 | Neutral search technique for short-term pump schedule optimization显示文摘 | BENE J G SELEK I HS C | 2010 | Water Resour Plng Mgmt2010，136，1： | 1 |
| 4 | Respirometry techniques and activated sludge models显示文摘 | Benes O Spanjers H Holba M | 2002 | Water Sci Technol2002，46，45： | 1 |
| 5 | Rapid activation and nuclear translocation of mitogen- activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line 显示文摘 | Benes C Roisin M P Van Tan H | 1998 | J Biol Chem1998，273，15： | 1 |
| 6 | Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion on-cogene EML4-ALK显示文摘 | Katayama R Khan T M Benes C Lifshits E Ebi H Rivera V M | 2011 | Proc Natl Acad Sci USA2011，108，： | 1 |
| 7 | Expression of a novel form of the p56lck protooncogene in rat cerebellar granular neurons显示文摘 | Van Tan H Allee G Benes C | 1996 | J Neurochem1996，67，： | 1 |
| 8 | The C2 domain of PKC delta is a phosphotyrosine binding domain 显示文摘 | BENES C H WU N ELIA A E | 2005 | Ce112005，121，2： | 1 |
| 9 | Increased glutathione Stransferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease显示文摘 | WHITWORTH A J THEODORE D A GREENE J C BENES H WES P D PALLANCK L J | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，22： | 1 |
| 10 | Biological activity of paediatric cerebral cavernomas:an immunohistochemical study of 28 patients 显示文摘 | Bertalanffy H Benes Luwig Miyazawa T | 2006 | Childs Nerv Syst2006，22，7： | 1 |
| 11 | Ceramic-sup-ported thin PVA pervaporation membranes combining high flux and high selectivity;contradicting the flux-selectivity paradigm 显示文摘 | Peters T A Poeth C H S Benes N E | 2006 | Journal of Membrane Science2006，276，12： | 1 |
| 12 | Cerebral caver- nomas in the adult: review of the literature and analysis of 72 surgically treated patients 显示文摘 | Bertalanffy H Benes L Miyazawa T | 2002 | Neurosurg Rev2002，25，12： | 1 |
| 13 | Corticotropin-releasing hormone affects short immobilization stress-inducedchanges in lung cytosolic and membrane glucocorticoid bindingsites 显示文摘 | Benes J Tomankova H Novakova M | 2013 | Cell Mol Neurobiol2013，33，4： | 1 |
| 14 | Microporous silica membranes, Recent advances in gas separations by mi croporous membranes显示文摘 | Benes N E Nijmeijer A Verweij H | 2000 | N Kannellopoulos2000，6，： | 1 |
| 15 | Biosaline agriculture for forage and livestock production显示文摘 | Masters D G Benes S E Norman H C | 2007 | Agriculture Ecosystems & Environment2007，119，34： | 1 |
| 16 | Early effects of short-time cigarette smoking on the human lung: a study of bronchoalveolar lavage fluid 显示文摘 | Mancini NM Bene MC Gerard H | 1993 | Lung1993，171，5： | 1 |
| 17 | Studies on the molecular-genetic basis of replicative senescence in Werner syndrome and normal fibroblasts显示文摘 | Goldstein S Murano S Benes H | 1989 | Exp Gerontol1989，24，56： | 1 |
| 18 | Optical controlof zebrafish behavior with halorhodopsin显示文摘 | Arrenberg AB Del Bene F Baler H | 2009 | Pro Nat Acad Sci U S A2009，106，17： | 1 |
| 19 | Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised,double-blind, placebo-controlled trial显示文摘 | Trenkwalder C Benes H Poewe W | 2008 | Lancet Neurol2008，7，7： | 1 |
| 20 | Ropinirole improves depressive symptoms and restless legs syndrome severity in RLS patients: a multicentre, randomized, placebo-controlled study 显示文摘 | Benes H Mattern W Peglau I | 2011 | J Neurol2011，258，6： | 1 |
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