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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 2 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | Effect β-glucan from oat and yeast on serum lipids显示文摘 | Bell S Coldmanm V M Bistrian B R | 1999 | Critical reviews in food science and nutrition1999，39，： | 1 |
| 5 | Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternative spliced exons显示文摘 | Screaton G R Bell M V Jackson D G | 1992 | Proc Natl Acad Sci USA1992，89，12： | 1 |
| 6 | Epigenetie inactivation of14-3-3 sigma in oral carcinoma : association with p16 (INK4a) silencing and human papillomavirus negativity 显示文摘 | Gasco M Bell AK Heath V | 2002 | Cancer Res2002，62，： | 1 |
| 7 | Requirement criteria for essential fatty acid 显示文摘 | Sargent J R Bell J G Bell M V | 1995 | J Appl Iehthyol1995，11，： | 1 |
| 8 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 1 |
| 9 | Infectious hypodermal and haematopoietic necrosis, a newly recognized virus disease of penaeid shrimp 显示文摘 | Lighter D V Redman R M Bell T A | 1983 | J Invertebr Pathol1983，42，： | 1 |
| 10 | Requirement criteria for essential fatty acids显示文摘 | Sargent J R Bell J G Bell M V Henderson R J Tocher D R | 1995 | J Appl Ichthyol1995，11，： | 1 |
| 11 | Origins of long-chain polyunsaturated fatty acids in the hydrothermal vent worms Ridgea pisceae and Protis hydrothermica显示文摘 | POND D W ALLEN C E BELL M V | 2002 | Marine Ecology Progress Series2002，225，： | 1 |
| 12 | Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons显示文摘 | Screaton G R Bell M V Jackson D G | 1992 | Proc Natl Acad Sic USA1992，89，12： | 1 |
| 13 | Lipid nutrition of marine fish during early development:current status and future directions显示文摘 | Sargent J R McEvoy L A Estevez A Bell J G Bell M V Henderson R J Tocher D R | 1999 | Aquaculture1999，179，： | 1 |
| 14 | Fatty acid compositions of gonadal material and diets of the sea urchin,Psammechinu smilliaris:trophic and nutritional implications显示文摘 | COOK E J BELL M V BLACK K D | 2000 | Journal of Experimental Marine Biology and Ecology2000，255，： | 1 |
| 15 | Molecular species composition of phosphatidylinositol from brain,retina,liver and musle of cod (Gadus morhua)显示文摘 | BELL M V DICK J R | 1990 | Lipids1990，25，： | 1 |
| 16 | Therole of polyunsaturated fatty acidsin fish显示文摘 | BELL M V HENDERSON R J SARGENT J R | 1986 | Comp BiochemPhysiol B1986，83，4： | 1 |
| 17 | Sulfasalazine induced oxidative stress a possible mechanism of male infertility 显示文摘 | Alonso V Linares V Belles M | 2009 | Reprod Toxicol2009，27，： | 1 |
| 18 | Flexural properties of fiber reinforced root canal posts 显示文摘 | Lassila L V Tanner J Le Bell A M | 2004 | Dent Mater2004，20，1： | 1 |
| 19 | Suppressing subordinate reproduction provides benefits to dominants in cooperative societies of meerkats 显示文摘 | Bell M B V Cant M A Borgeaud C | 2014 | Nature Communications2014，5，： | 1 |
| 20 | Decreased 20:4n-6/20:5n-3 ratio in sperm from cultured sea bass Dicentrarchus labrax, broodstock compared to wild fish显示文摘 | Dick J R Thrush M | 1996 | Aquaculture1996，144，： | 1 |
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