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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Diversity of Microcystis aeruginosa isolates ( Chroococcales, Cyanobacteria) from East-African water bodies 显示文摘 | Haande S Ballot A Rohrlack T | 2007 | Arch Microbiol2007，188，： | 1 |
| 3 | Contribution of hot spring cya-nobacteria to the mysterious death of Lesser Flamingos at Lake BogoriaKenya显示文摘 | KRIENITZ L BALLOT A KOTUT K | 2003 | FEMS Microbiology Ecology2003，43，2： | 1 |
| 4 | Cyanobacteria and cyanobacteri- al toxins in three alkaline Rift Valley lakes of Kenya-Lakes Bogo- ria, Nakuru and Elmenteita显示文摘 | Ballot A Krienitz L Kotut K | 2004 | Journal of Plankton Research2004，26，8： | 1 |
| 5 | Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities显示文摘 | CASTERA L HATZFELD-CHARBONNIER A S BALLOT C | 2009 | Journal of Cellular and Molecular Medicine2009，13，7： | 1 |
| 6 | Contribution of hot spring cyanobacteria to the mysterious death of Lesser Flamingos at Lake Bogoria Kenya显示文摘 | KRIENITZ L BALLOT A KOTUT K | 2003 | FEMS Microbiology Ecology2003，43，2： | 1 |
| 7 | The serum inhibin B concentration and reference ranges in normozoospermia显示文摘 | BARBOTIN A L BALLOT C SIGALA J | 2015 | Eur J Endocrinol2015，14，： | 1 |
| 8 | Detection on immunoblot of new proteins from the soluble fraction of the cell recognized either by anti-liver-kidney microsome antibodies type 1 or by anti-liver cytosol antibodies type 1-relationship with hepatitis C virus infection显示文摘 | Desbos A Monier JC | 1996 | Clin Immunol Immunopathol1996，80，3： | 1 |
| 9 | Detection on immunoblot of new proteins from the microsomal fraction recognized by anti - liver- kidney microsome antibodies type 1 显示文摘 | Desbes A Auger C | 1996 | Clin Immunol Immunopathol1996，80，： | 1 |
| 10 | Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D显示文摘 | Ballot C Kluza J Martoriati A | | 0，，12： | 1 |
| 11 | Diversity of Microcystis aeruginosa isolates (Chroococcales, Cyanobacteria) from East-African water bodies显示文摘 | HAANDE S BALLOT A ROHRLACK T | 2007 | Archives of Microbiology2007，188，1： | 1 |
| 12 | Contribution of hot spring cyanobacteria to the misterious deaths of lesser Flamingosat Lake Bogoria, Kenya显示文摘 | Krienitz L Ballot A Kotut K | 2003 | FEMS Microbiol Ecol2003，，43： | 1 |
| 13 | Serum 1,3-betaD-Glucan as-say in the diagnosis of invasive fungal disease in neonates 显示文摘 | Mackay C A Ballot D EPerovic 0 | 2011 | Ped-iatr Rep2011，3，2： | 1 |
| 14 | Contribution of hot spring cyanobacteria to the mysterious deaths of Lesser Flamingos at Lakc Bogoria,Kenya显示文摘 | KRIENITZ L BALLOT A KOTUT K | 2003 | FEMS Microbiology Ecology2003，43，2： | 1 |
| 15 | Cyanobacterial toxins in Lake Baringo, Kenya显示文摘 | Ballot A Stephan Pflugmacher Claudia Wiegand | 2003 | Limnologica2003，33，： | 1 |
| 16 | All-atom empirical potential for molecular modeling and dynamics studies of proteins显示文摘 | MACKERELL A D BALLOT M | 1998 | J Phys Chem B1998，102，： | 1 |
| 17 | Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D显示文摘 | Ballot C Kluza J Martoriati A | 2009 | Mol Cancer Ther2009，8，12： | 1 |
| 18 | Diversity of Microcystis aeruginosaisolates ( Chroococcales, Cyanobacteria ) from East- African water bodies 显示文摘 | Haande S Ballot A Rohrlack T | 2007 | Arch M icrobiol2007，188，1： | 1 |
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