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		题名	作者	年代	出处	被引量
	1	Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity显示文摘In this study,three new germacranolide sesquiterpenes(1–3),together with six related known analogues(4–9)were isolated from the whole plant of Carpesium cernuum.Their structures were established by a combination of extensive NMR spectroscopic analysis,HR-ESIMS data,and ECD calculations.The anti-leukemia activities of all compounds towards three cell lines(HEL,KG-1a,and K562)were evaluated in vitro.Compounds 1–3 exhibited moderate cytotoxicity with IC50 values ranging from 1.59 to 5.47μmol·L^(−1).Mechanistic studies indicated that 2 induced apoptosis by decreasing anti-apoptotic protein Bcl-2 and activating the caspase family in K562 cells.These results suggest that compound 2 is a potential anti-leukemia agent.	YAN Chen LONG Qun ZHANG Yun-Dong BABU Gajendran KRISHNAPRIYA Madhu Varier QIU Jian-Fei SONG Jing-Rui RAO Qing YI Ping SUN Mao LI Yan-Mei	2021	Chinese Journal of Natural Medicines2021，19，7：	3

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