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| 1 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 2 | The electronic and magnetic properties of wurtzite Mn:CdS, Cr:CdS and Mn:Cr:CdS: first principles calculations显示文摘In this article, density functional theory(DFT) based on generalized gradient approximation(GGA)and GGACU, U is Hubbard term, is used to study the electronic properties of CdS doped with different dopants(Cr, Mn). The calculations are carried out for Mn-doped CdS, Cr-doped CdS, and co-doping of Mn/Cr in CdS simultaneously. It is found that hopping of electrons is possible with Cr:CdS and Mn:Cr:CdS while Mn:CdS does not allow the hopping of electrons. Moreover, double exchange interactions are observed in Cr:CdS and d-d superexchange interactions are observed in Mn:CdS. Now the problem becomes interesting when one magnetic ion(Cr) supporting double exchange interactions and another ion(Mn) supporting d-d super-exchange interactions are doped simultaneously in the same system(CdS). The co-doped CdS is more stable even at high Curie temperature due to p-d double exchange interactions and d-d super exchange interactions. Furthermore, the Cr-3d and Mn-3d states present in-between the band gap are responsible for inner shell transitions and hence for optical properties.Therefore, the co-doped system is taken into account to enhance its applications in the field of spintronic and magneto-optical devices. | Azeem Nabi Zarmeena Akhtar Tahir Iqbal Atif Ali Muhammad Arshad Javid | 2017 | Journal of Semiconductors2017，38，7： | 2 |
| 3 | Role of SNPs in determining QTLs for major traits in cotton显示文摘A single nucleotide polymorphism is the simplest form of genetic variation among individuals and can induce minor changes in phenotypic,physiological and biochemical characteristics.This polymorphism induces various mutations that alter the sequence of a gene which can lead to observed changes in amino acids.Several assays have been developed for identification and validation of these markers.Each method has its own advantages and disadvantages but genotyping by sequencing is the most common and most widely used assay.These markers are also associated with several desirable traits like yield,fibre quality,boll size and genes respond to biotic and abiotic stresses in cotton.Changes in yield related traits are of interest to plant breeders.Numerous quantitative trait loci with novel functions have been identified in cotton by using these markers.This information can be used for crop improvement through molecular breeding approaches.In this review,we discuss the identification of these markers and their effects on gene function of economically important traits in cotton. | MAJEED Sajid RANA Iqrar Ahmad ATIF Rana Muhammad ALI Zulfiqar HINZE Lori AZHAR Muhammad Tehseen | 2019 | Journal of Cotton Research2019，2，1： | 2 |
| 4 | Heat stress-induced alterations of antioxidants in the freshwater fish Channa punctata Bloch 显示文摘 | Kaur M Atif F Ali M Rehman H Raisuddin S | 2005 | Journal of Fish Biology2005，67，： | 1 |
| 5 | Modulatory effect of cadmium injection on endosulfan-induced oxidative stress in the freshwater fish, Channa punctata Bloeh 显示文摘 | Atif F Ali M Kaur M | 2005 | Bulletin of Environmental Contamination and Toxicology2005，74，4： | 1 |
| 6 | Syntheses,Spectral Studies and Bioanalyses of Some Triorganotin(IV) Complexes of Cephlaxine显示文摘Five novel triorganotin(IV) complexes have been synthesized by refluxing tri-methyl, triethyl, tributyl, triphenyl and tribenzyltin chloride with Cephlaxine. These compounds were characterized by spectroscopic (IR, 1H, 13C, 119Sn NMR) techniques and elemental analysis. The results obtained through these techniques are in full agreement with the proposed 1:1 stoichiometry. The synthesized compounds were than tested against various microorganisms and fungi. The results of new products obtained showed that the triphenyltin(IV) complex displayed promising activity against all types of bacteria and fungi used while all other compounds showed significant antibacterial and antifungal activity. | Wajid Rehman Bakhtiar Muhammad Farman Ali Sardar Atif | 2008 | Chinese Journal of Structural Chemistry2008，27，7： | 1 |
| 7 | Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single vs multivessel disease显示文摘BACKGROUND Even though percutaneous coronary intervention(PCI)improved the survival of patients with acute myocardial infarction,still multivessel coronary artery disease remains an important factor burdening prognosis and it is being associated with a worse prognosis compared to single-vessel disease(SVD).AIM To compare the clinical profile and outcomes after the primary PCI in young patients with SVD vs multivessel disease(MVD).METHODS The retrospective cohort of patients were divided into two groups:SVD and MVD group.The study population consisted of both male and female young(≤45 years)patients presented with ST-elevation myocardial infarction(STEMI)at the National Institute of Cardiovascular Disease,Karachi,Pakistan and undergone primary PCI from 1 st July 2017 to 31 st March 2018.Pre and postprocedure management of the patients was as per the guidelines and institutional protocols.RESULTS A total of 571 patients with STEMI,≤45 years were stratified into two groups by the number of vessels involved,342(59.9%)with SVD and 229(40.1%)with MVD.The average age of these patients was 39.04±4.86 years.A lower prevalence of hypertension and diabetes was observed in SVD as compare to MVD group(25.1%vs 38%,P<0.01;11.7%vs 27.5%,P<0.001)respectively.While,smoking was more prevalent among the SVD group as compare to MVD group(36.3%vs 28.4%,P=0.05).The high-C Lesion was observed in a significantly higher number of younger patients with MVD as compared to SVD group(48.8%vs 39.2%,P=0.021).Post-procedure thrombolysis in myocardial infarction flow grade was found to be not associated with the number of diseased vessels with a P value of 0.426 and thrombolysis in myocardial infarction flow grade III was observed in 98%vs 96.5%of the patients is SVD vs MVD group.CONCLUSION The MVD comprised of around 40%of the young patients presented with STEMI.Also,this study shows that diabetes and hypertension have a certain role in the pathogenesis of multivessel diseases,therefore,preventive measures for diabetes and hypertension can be effective strategies in reducing the burden of premature STEMI. | Atif Sher Muhammad Tariq Ashraf Ayaz Mir Syed Alishan Faiza Farooq Ali Ammar Musa Karim Syed Nadeem Hassan Rizvi Tahir Saghir Jawaid Akbar Sial Naveed Ullah Khan | 2020 | World Journal of Cardiology2020，12，4： | 1 |
| 8 | Foliar Application of Phosphorus Enhances Photosynthesis and Biochemical Characteristics of Maize under Drought Stress显示文摘Water is essential for the growth period of crops;however,water unavailability badly affects the growth and physiological attributes of crops,which considerably reduced the yield and yield components in crops.Therefore,a pot experiment was conducted to investigate the effect of foliar phosphorus(P)on morphological,gas exchange,biochemical traits,and phosphorus use efficiency(PUE)of maize(Zea mays L.)hybrids grown under normal as well as water deficit situations at the Department of Agronomy,University of Agriculture Faisalabad,Pakistan in 2014.Two different treatments(control and P@8 kg ha^(−1))and four hybrids(Hycorn,31P41,65625,and 32B33)of maize were tested by using a randomized complete block design(RCBD)with three replications.Results showed that the water stress caused a remarkable decline in total soluble protein(9.7%),photosynthetic rate(9.4%)and transpiration rate(13.4%),stomatal conductance(10.2%),and internal CO_(2)rate(20.4%)comparative to well-watered control.An increase of 37.1%,36.8%,and 24.5%were recorded for proline,total soluble sugar,and total free amino acid,respectively.However,foliar P application minimized the negative impact of drought by improving plant growth,physio-biochemical attributes,and PUE in maize plants under water stress conditions.Among the hybrids tested,the hybrid 6525 performed better both under stress and non-stress conditions.These outcomes confirmed that the exogenous application of P improved drought stress tolerance by modulating growth,physio-biochemical attributes,and PUE of maize hybrids. | Zahoor Ahmad Ejaz Ahmad Waraich Muhammad Zia ur Rehman Muhammad Ashar Ayub Muhammad Usman Hesham Alharby Atif Bamagoos Celaleddin Barutçular Muhammad Ali Raza FatihÇiğ Ayman El Sabagh | 2021 | Phyton-International Journal of Experimental Botany2021，90，2： | 1 |
| 9 | Hepatic portal venous gas due to cryptosporidiosis in a patient with acquired immunodefi ciency syndrome显示文摘Although the presence of hepatic portal venous gas (HPVG) on computed tomography (CT) is typically an ominous finding, HPVG may sometimes be less catastrophic. The clinical significance of HPVG is variable, and it depends primarily on the underlying pathol ogy. We report a case of a patient with acquired immunodeficiency syndrome (AIDS) who was found to have HPVG on CT as a presumed result of gastrointestinal cryp tosporidiosis, an association that, to our knowledge, has not been reported. This case illustrates another cause of HPVG that should be considered in patients with AIDS. | Nilesh Lodhia Atif Ali Joel Bessoff | 2010 | World Journal of Hepatology2010，2，11： | 0 |
| 10 | Two novel variants in CYP1B1 gene: a major contributor of autosomal recessive primary congenital glaucoma with allelic heterogeneity in Pakistani patients显示文摘AIM: To find the CYP1 B1 mutations associated with primary congenital glaucoma(PCG) in Pakistani consanguineous pedigrees. METHODS: After getting informed consent, 11 consanguineous pedigrees belonging to different ethnic groups were enrolled. Detailed medical history was recorded and pedigrees were drawn. The standard ophthalmological examination was done to characterize the phenotype. Genomic DNA was extracted from 10 mL whole blood and coding exons and exon intron boundaries of CYP1 B1 gene were directly sequenced. Bioinformatics tools were used to model the mutant protein and predict the effect of novel variants on protein structure and function. RESULTS: Sequencing analysis revealed 5 different CYP1 B1 variants in 7 families(7/11; 64%), including two novel variants. A common mutation, p.R390 H was found in four families, whereas p.P437 L was found once in a family. Two novel variants, a homozygous non sense variant p.L13* and a compound heterozygous variant, p.P350 T along with p.V364 M were segregating with PCGin two families. All the patients had the variable onset and severity of the disease. The success rate of early clinical interventions was observed dependent on mutation types and position. Two different haplotypes were associated with frequently found mutation, p.R390 H. CONCLUSION: Identification of novel CYP1 B1 variants reassert the genetic heterogeneity of Pakistani PCG patients. The patients with missense mutations show severe phenotypic presentations and poor vision after surgical interventions as compare to patients with null variants. This may help to better understand the role of CYP1 B1 mutations in the development of PCG and its course of pathogenicity. | Yar Muhammad Waryah Muhammad Iqbal Shakeel Ahmed Sheikh Muhammad Azhar Baig Ashok Kumar Narsani Muhammad Atif Munir Ahmad Bhinder Attiq Ur Rahman Azam Iqbal Memon Muhammad Suleman Pirzado Ali Muhammad Waryah | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 0 |
| 11 | Detection of ROS and translocation of ERP-57 in apoptotic induced human neuroblastoma(SH-SY5Y)cells显示文摘Several toxic compounds are known to induce apoptosis in mammalian cell lines.The human neuroblastoma cells(SHSH-SY5Y)were exposed to the phosphatase inhibiting toxin okadaic acid(OA)or hydrogen peroxide(H2O2)to induce apoptosis as well as generate reactive oxygen species(ROS).Mitoxantrone(MXT)was used as a positive control for apoptosis.The SHSH-SY5Y cells were transfected with eukaryotic expression plasmid pHyPer-dMito encoding mitochondrial-targeted fluorescent or pHyPer-dCito encoding cytoplasmic-targeted fluorescent sensor for hydrogen peroxide(HyPer).The ERp57,also called GRP58(Glucose-regulated protein 58),is a stress protein induced in conditions like glucose starvation and viral infection.Recently ERp57 was shown to translocate from the endoplasmatic reticulum to the cell surface in anthracycline-induced apoptotic cells.ERp57 co-translocation together with calreticulin has been suggested to be crucial for recognizing tumor cells to induce immunogenic cell death.ERp57 translocation after exposure to okadaic acid was studied using immunofluorescence and confocal microscopy.These studies indicated that okadaic acid has induced the translocation of ERp57 to the cellular membrane. | ATIF KAMIL MUBARAK ALI KHAN MUHAMMAD AASIM NADIR ZAMAN KHAN RAHAM SHER KHAN MUHSIN JAMAL WAQAR AHMAD MIR AZAM KHAN FAZAL JALIL | 2019 | BIOCELL2019，43，3： | 0 |
| 12 | Mathematical Analysis of Novel Coronavirus (2019-nCov) Delay Pandemic Model显示文摘In this manuscript,the mathematical analysis of corona virus model with time delay effect is studied.Mathematical modelling of infectious diseases has substantial role in the different disciplines such as biological,engineering,physical,social,behavioural problems and many more.Most of infectious diseases are dreadful such as HIV/AIDS,Hepatitis and 2019-nCov.Unfortunately,due to the non-availability of vaccine for 2019-nCov around the world,the delay factors like,social distancing,quarantine,travel restrictions,holidays extension,hospitalization and isolation are used as key tools to control the pandemic of 2019-nCov.We have analysed the reproduction number��������������������of delayed model.Two key strategies from the reproduction number of 2019-nCov model,may be followed,according to the nature of the disease as if it is diminished or present in the community.The more delaying tactics eventually,led to the control of pandemic.Local and global stability of 2019-nCov model is presented for the strategies.We have also investigated the effect of delay factor on reproduction number��R_(nCov).Finally,some very useful numerical results are presented to support the theoretical analysis of the model. | Muhammad Naveed Muhammad Rafiq Ali Raza Nauman Ahmed Ilyas Khan Kottakkaran Sooppy Nisar Atif Hassan Soori | 2020 | Computers, Materials & Continua2020，，9： | 0 |
| 13 | General Solution for Unsteady Natural Convection Flow with Heat and Mass in the Presence of Wall Slip and Ramped Wall Temperature显示文摘This work is focused on the effect of heat and mass transfer with unsteady natural convection flow of viscous fluid along with ramped wall temperature under the assumption of the slip wall condition at the boundary. Analytical solutions are obtained by using Laplace transformation to the non-dimensional set of governing equations containing velocity, temperature and concentration. Moreover, the expression for skin-friction is derived by differentiating the analytical solutions of fluid velocity. Numerical tables for Skin-friction, Sherwood number and Nusselt-number are examined. For the physical aspects of the flow, we use various values of involved physical parameters such as Prandtl number(Pr), slip parameter(η), Schmidt number(Sc), buoyancy ratio parameter(N), Sherwood number(Sh), and time(t). Additionally, the general solutions are plotted graphically and a comprehensive theoretical section of numerical discussions is included. | Saeed Ullah Jan Sami Ul Haq Syed Inayat Ali Shah Ilyas Khan Muhammad Atif Khan | 2019 | Communications in Theoretical Physics2019，71，6： | 0 |
| 14 | Treatment of Polio Delayed Epidemic Model via Computer Simulations显示文摘Through the study,the nonlinear delayed modelling has vital significance in the different field of allied sciences like computational biology,computational chemistry,computational physics,computational economics and many more.Polio is a contagious viral illness that in its most severe form causes nerve injury leading to paralysis,difficulty breathing and sometimes death.In recent years,developing regions like Asia,Africa and sub-continents facing a dreadful situation of poliovirus.That is the reason we focus on the treatment of the polio epidemic model with different delay strategies in this article.Polio delayed epidemic model is categorized into four compartments like susceptible,exposed,infective and vaccinated classes.The equilibria,positivity,boundedness,and reproduction number are investigated.Also,the sensitivity of the parameters is analyzed.Well,known results like the Routh Hurwitz criterion and Lyapunov function stabilities are investigated for polio delayed epidemic model in the sense of local and global respectively.Furthermore,the computer simulations are presented with different traditions in the support of the analytical analysis of the polio delayed epidemic model. | Muhammad Naveed Dumitru Baleanu Ali Raza Muhammad Rafiq Atif Hassan Soori | 2022 | Computers, Materials & Continua2022，，2： | 0 |
| 15 | Treatment of irritable bowel syndrome with multi-herbal formula: A case report显示文摘Background: Many patients with irritable bowel syndrome (IBS) try the approach of complementary or herbal medicines, as western medications do not treat IBS. The current case report presents the combine effect of four herbal components as a traditional treatment of IBS. Method: The herbal components were purchased from the local market. The components including Lipidium sativum L., Trigonella foenum-graceum L., Myristica fragrance Hoyutt. and Apium graveolens Linn were ground and mixed well (dry weight), and took orally for two days as advised by the local healer. Results: The symptoms included loose bowel movements accompanied by prolonged flatulence abdominal cramping, faecal urgency as well as mucus discharge were improved and remain suppressed for 5 to 6 months afterthe treatment with multi-herbal formula. Conclusion: The current case report showed that the multi-herbal formula might be a promising treatment for IBS-diarrhoea. | Atif Ali Khan Khalil | 2021 | Drug Combination Therapy2021，3，3： | 0 |
| 16 | Early Diagnosis of Alzheimer’s Disease Based on Convolutional Neural Networks显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder,causing the most common dementia in the elderly peoples.The AD patients are rapidly increasing in each year and AD is sixth leading cause of death in USA.Magnetic resonance imaging(MRI)is the leading modality used for the diagnosis of AD.Deep learning based approaches have produced impressive results in this domain.The early diagnosis of AD depends on the efficient use of classification approach.To address this issue,this study proposes a system using two convolutional neural networks(CNN)based approaches for an early diagnosis of AD automatically.In the proposed system,we use segmented MRI scans.Input data samples of three classes include 110 normal control(NC),110 mild cognitive impairment(MCI)and 105 AD subjects are used in this paper.The data is acquired from the ADNI database and gray matter(GM)images are obtained after the segmentation of MRI subjects which are used for the classification in the proposed models.The proposed approaches segregate among NC,MCI,and AD.While testing both methods applied on the segmented data samples,the highest performance results of the classification in terms of accuracy on NC vs.AD are 95.33%and 89.87%,respectively.The proposed methods distinguish between NC vs.MCI and MCI vs.AD patients with a classification accuracy of 90.74%and 86.69%.The experimental outcomes prove that both CNN-based frameworks produced state-of-the-art accurate results for testing. | Atif Mehmood Ahed Abugabah Ahmed Ali AlZubi Louis Sanzogni | 2022 | Computer Systems Science & Engineering2022，43，10： | 0 |
| 17 | Case synthesis of a β-chloro bulky bis-pocket corrole:Crystallographic characterization and photophysical properties显示文摘A new 2-chloro-5,10,15-tris(2,4,6-triphenylphenyl)-corrole was accidentally synthesized in an acceptable yield of 5.7% during the synthesis of its parent corrole, in which DDQ served as oxidant and chlorinating agent. The compound was well characterized by X-ray diffraction analysis, ~1 H NMR, mass spectroscopy and absorption spectroscopy. Photophysical properties tests revealed that the chlorination caused a sharp decrease in fluorescence intensity, fluorescence life time, and fluorescence quantum yield.Electrochemical investigation demonstrated the positive shift of redox potentials for chlorinated corrole as compared to non-chlorinated corrole. | Atif Ali Fan Cheng Wei-Hong Wen Xiao Ying Jaipal KANDhadi Hui Wang Hai-Yang Liu Chi-Kwong Chang | 2018 | Chinese Chemical Letters2018，29，12： | 0 |
| 18 | Silver(Ⅱ) 5,10,15,20-tetra(ethoxycarbonyl) porphyrin:An unexpected six-coordinate linear assembled structure显示文摘The crystal structure of silver(Ⅱ) 5,10,15,20-tetra(ethoxycarbonyl)porphyrin(Ag[Ⅱ]TECP) revealed it formed a one-dimensional coordination polymer through weak Ag–O interactions with an unusual sixcoordinated central silver(Ⅱ) atom. | Hua-Hua Wang Hai-Yang Liu Fan Cheng Atif Ali Lei Shi Xin-Yan Xiao Chi-Kwong Chang | 2018 | Chinese Chemical Letters2018，29，9： | 0 |
| 19 | 一种基于多分辨率分解和去相关的模块化安全性与鲁棒性彩色图像水印方案(英文)显示文摘提出一种基于多分辨率分解和去相关的模块化安全性与鲁棒性彩色图像水印方案。该方案主要目标是同时满足良好水印的4个要求(鲁棒性、安全性、不可察觉性和容量)。本研究的贡献在于实现一个基本满足这4个矛盾需求的水印方案。为此,结合不同方法以实现这个目的。例如,为获得不可察觉性,通过主成分分析去相关3个颜色(红绿蓝)通道,并选择第一个主成分(去相关红色通道)嵌入水印。为取得鲁棒性,采用离散小波变换(DWT)分解去相关信道,将近似带(其余3个带保持不变以保留边缘信息)进一步分解为不同区块。根据随机生成键选择随机区块。随机选取的区块进一步被分解为奇异值和向量。基于奇异值和向量矩阵的相互依赖性,并依据水印位,对数值进行修改,并保存这些数值的位置,将数值位置作为提取水印所需的另一个密钥。两级认证级别确保了安全性,同时使用奇异值和向量可提高该方案的容量。此外,在水印嵌入过程中,左右奇异向量与奇异值的结合增强了该方案的鲁棒性。最后,使用Gonzalez和Kodak数据集,从不可察觉性(峰值信噪比和结构相似性指数)、安全性(带多个伪密钥)、鲁棒性(归一化相关和误码率)和容量方面将该方案与已有方案作比。结果显示本文方案与现有方案相比有明显改进。 | Muhammad IMRANz Bruce AHARVEY Muhammad ATIF Adnan Ali MEMON | 2019 | Frontiers of Information Technology & Electronic Engineering2019，20，7： | 0 |
| 20 | Ultrathin organic polymer with p-πconjugated structure for simultaneous photocatalytic disulfide bond generation and CO_(2)reduction显示文摘Combining photocatalytic organic reactions with CO_(2)reduction is an efficient solar energy utilization mode,but it is still limited by the organic species that can be matched and the low conversion.Herein,ultrathin organic polymer with p-πconjugated structure(TPP)was rationally designed and prepared,and showed a high yield of CO(15.2 mmol g^(-1))and conversion of SAS coupled products(100%),far exceeding the organic polymer with P=O structure.The enhanced photoredox activity of TPP is ascribed to the orbital interaction between the p-orbital on phosphorus and theπ-orbitals of aromatic,which can accelerate the photoinduced charge carrier separation and improve the CO_(2)adsorption capacity.TPP can also be used for the dehydrocoupling of various benzyl mercaptans to the corresponding SAS bond products.This work provides a new concept for the efficient synthesis of disulfide bonds combined with CO_(2)reduction in a photoreaction system. | Linquan Hou Zhunyun Tang Guojiang Mao Shiheng Yin Bei Long Tao Ouyang Guo-Jun Deng Atif Ali Ting Song | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
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