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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Prevalence of plasmid mediated bla_(TEM-1) and bla_(CTX-M-15) type extended spectrum beta-lactamases in patients with sepsis显示文摘Objective:To characterize the bacterial pathogens in patients having gram negative septicaemia. Further,to evaluate the antimicrobial resistance and underlying molecular mechanisms in these strains.Methods:A total number of 70 cases of gram negative sepsis were included in this prospective,open labeled,observational study.Standard methods for isolation and identification of bacteria were used.Antimicrobial susceptibility and ESBL testing was performed by the standard disc diffusion method.PCR amplification was performed to identify blaCTX-M,blaSHVand blaTEM type ESBLs.Conjugation experiments were performed to show resistant marker transfer. Results:The most prevalent isolates Escherichia coli(E.coli) 58.6%,Klebsiella Spp.32.9%and Pseudomonas 8.6%,were resistant to most of the antimicrobials including cefazolin,ceftriaxone, cefuroxime,ampicillin and co-trimoxazole but sensitive to imipenem and meropenem.ESBL and MBL production was seen 7.3%and 12.2%of E.coli isolates respectively.Three isoaltes were found to have blaCTX-M-15 and two of them also showed blaTEM-1 type enxyme.Whereas, none of them showed blaSHV.Conjugation experiments using J-53 cells confirmed these resistant markers as plasmid mediated.Conclusions:This work highlights the molecular epidemiology of escalating antimicrobial resistance and likely switch over of blaCTX-M-15 type extended spectrum beta-lactamases by blaTEM type ESBLs in India.Further,the antimicrobial resistance by horizontal gene transfer was predominant among Enterobacteraceae in the community setting. | Shahzad F Haque Saeedut-Z Ali Mohammed TP Asad U Khan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 2 |
| 3 | Introducing problem-based learning in a medical school with traditional/conventional curriculum显示文摘 | Baig LA Asad F | 2003 | J-CollPhysicians-Surg-Pak2003，13，7： | 2 |
| 4 | Numerical and experimental study of dry cutting for an aeronautic aluminium alloy(A2024-T351)显示文摘 | MABROUKI T GIRARD1N F ASAD M | 2008 | International Journal of Machine Tools and Manufacture2008，48，11： | 1 |
| 5 | Introducing problem-based learning in a medical school with traditional/conventional curriculum显示文摘 | Baig IA Asad F | 2003 | J Coll Physicians Surg Pak2003，13，7： | 1 |
| 6 | Introducing Problem-Based Learning in a medical school with traditional/con-ventional curriculum显示文摘 | Baig LA Asad F | 2003 | J Coil Physicians Surg Pak2003，13，7： | 1 |
| 7 | Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu (Ⅱ)显示文摘 | Singh S Asad S F Ahmad A | 2001 | Cancer Left2001，169，： | 1 |
| 8 | Interaction of binders with dispersant stabilised alumina suspensions显示文摘 | ASAD U K BRIAN J B PAUL F L | 2000 | Colloids Surf A: Phys Chem Eng Aspects2000，161，： | 1 |
| 9 | Intruducing problem-based leafing in a medical school with traditional/convertional curriculum显示文摘 | Baig LA Asad F | | 0，，07： | 1 |
| 10 | Introducing problem based learning in a medical school with traditional/conventional curriculum 显示文摘 | Baig LA Asad F | 2003 | J Coil Physicians Surg Pak2003，13，7： | 1 |
| 11 | Effect of a single bolus of dexametha-sone on intraoperative and postoperative pain in unilateralinguinal hernia surgery显示文摘 | Asad M V Khan F A | 2015 | J Anaesthesiol Clin Pharmacol2015，31，3： | 1 |
| 12 | CMOS comes of age显示文摘 | Asad A Abidi R F | 2004 | IEEE Journal of Solid-state Circuits2004，39，4： | 1 |
| 13 | Comparisionof effects of atorvastatin and budesonidein reduction of cardiovascular risk inchronic obstructive pulmonary diseasepatients 显示文摘 | Rizvi F Asad F Rizvi Q | 2013 | Medical Channel2013，19，4： | 1 |
| 14 | Introducing problem-based learning in a medical school with traditional/conventional curriculum显示文摘 | Baig LA Asad F | 2003 | J Coil Physicians Surg Pak2003，13，7： | 1 |
| 15 | Evaluation of slip in capillary extrusion of ceramic paste显示文摘 | Asad U K BrianJ B Paul F 1 | 2001 | J Euro Ceramic Soc2001，21，： | 1 |
| 16 | Nu- merical and Experiment Study of Cutting for an Aeronau- tic Aluminium Alloy 显示文摘 | MABROUKI Tarek GIRARDIN F ASAD M | 2008 | Journal of Manufacturing Sci- ence and Engineering-Transactions of the ASME2008，48，： | 1 |
| 17 | Introducing problem-based learning in a medical school with traditional/conventional curriculum显示文摘 | Baig LA Asad F | 2003 | J Coil Physicians SurqPak2003，13，7： | 1 |
| 18 | Introducing problem-based learning in a medical school with traditional/conventional curricu-lum显示文摘 | Baig LA Asad F | | 0，，07： | 1 |
| 19 | Introducing problem-based learning in a medical school with traditional/conventional curriculum显示文摘 | Asad F | 2003 | J-CollPhysicians-Surg-Pak2003，13，7： | 1 |
| 20 | Synthesis and charac- terization of cellulose acetate from TCF oil palm empty fruit bunch pulp 显示文摘 | Djuned F M Asad M Ibrahim M N M | 2014 | Bio Resources2014，9，3： | 1 |
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