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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 3 | Effects of Japaneseherbal medicine Inchin-ko-to on endoroxin-induced chole-stasis in the rat显示文摘 | Arab JP Ramirez C Munoz P | 2009 | Ann Hepatol2009，8，3： | 1 |
| 4 | An algorithm for clustering relational data with applications to social network analysis and comparison with multidimensional scaling显示文摘 | Breiger R L Boorman S A Arabic P | 1975 | Journal of Mathematical Psychology1975，12，： | 1 |
| 5 | Properties of TiSiN coatings deposited by hybrid HIPIMS and pulsed-DC magne- tron co- sputtering 显示文摘 | Arab P Y M Lomello F Wang J | 2014 | Vacuum2014，109，6： | 1 |
| 6 | Ability of stroke volume variation measured by oesophageal Doppler monitoring to predict fluid responsiveness during surgery显示文摘 | Guinot P G de Broca B Abou Arab O | 2013 | Br J Anaesth2013，110，1： | 1 |
| 7 | The role of endothelin-1 in myocarditis and inflammatory cardiomyopathy:old lessons and new insights显示文摘 | Yang LL Arab S Liu P | 2005 | Can J Physiol Pharmacol2005，83，1： | 1 |
| 8 | Homogenization of a reaction-diffusion system modeling sulfate corrosion of concrete in locally periodic perforated domains显示文摘 | Fatima T Arab N Zemskov E P | 2011 | Journal of Engineering Mathematics2011，69，2： | 1 |
| 9 | A non -syndrome form of neurosensory,recessive deafnessmaps to the pericentrometric region of chromosome 13q显示文摘 | Guilford P Ben Arab S Blanchard S | 1994 | Nat Genet1994，6，1： | 1 |
| 10 | Plasma lipid hydroper- oxides measurement by an automated xylenol orange method显示文摘 | ARAB K STEGHENS J P | 2004 | Anal Biochem2004，325，： | 1 |
| 11 | Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression 显示文摘 | Arabs S Merriam W G Bennett W P | 1998 | Cancer Res1998，58，2： | 1 |
| 12 | Comparing partitions显示文摘 | HUBERT L ARAB IE P | 1985 | Journal of Classifi-cation1985，2，1： | 1 |
| 13 | The role of air the bubbles in the desorption of ammonia from landfill leachate in high ph aerated lagoon显示文摘 | Arab F K | 1998 | Water Air and Soil Pult1998，38，34： | 1 |
| 14 | Multi-walled carbon nanotubes-ionic liquid-carbon paste electrode as a super selectivity sensor: Application to potentiometric monitoring of mercury ion显示文摘 | Khani H Rofouei MK Arab P | 2010 | Journal of Hazardous Materials2010，，183： | 1 |
| 15 | Nutritional risk factors for tuberculosis among adults in the United States, 1971-1992显示文摘 | Cegielski J P Arab L Cornoni-Huntley J | 2012 | Am J Epidemiol2012，176，5： | 1 |
| 16 | The role of endothelin-1 in myocarditis and inflammatory cardiomyopathy:Old lessons and new insights显示文摘 | Yang LL Arab S Liu P | 2005 | Can J Physiol Pharmacol2005，83，1： | 1 |
| 17 | Comparing partitions 显示文摘 | Hubert L Arabic P | 1985 | Journal of Classification1985，2，1： | 1 |
| 18 | Comparing partitions 显示文摘 | Hubert L Arabic P | 1985 | Journal of Classification1985，2，1： | 1 |
| 19 | The role of endothehn - 1 in myocarditis and inflammatory cardiomyopathy: old lessons and new insights 显示文摘 | Yang LL Arab S Liu P | 2005 | Can J Physiol Pharmacol2005，83，1： | 1 |
| 20 | Hydrothremal studies in the Aegean Sea显示文摘 | Dando P R Aliani S Arab H | 2000 | Phys Chem Earth(B)2000，25，1： | 1 |
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