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| 1 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 2 | Sythesis of L-and-D- methionine显示文摘 | Langstrom B Antoni G Gullberg P | 1987 | J Nucl Med1987，28，： | 1 |
| 3 | An overview of stress urinary incontinence treatment in women 显示文摘 | Papatsoris A G Chrisofos M Antoniou N | 2007 | Aging Clin Exp Res2007，19，4： | 1 |
| 4 | Verification and correctness issues for nonm- onotonic knowledge bases 显示文摘 | ANTONIOU G | 1998 | International Journal of Intel- ligent Systems1998，12，10： | 1 |
| 5 | Routine versus no drain placement after elective laparoscopic cholecystectomy:meta-analysis of randomized controlled trials显示文摘 | Antoniou S Koch O Antoniou G | 2014 | Minerva Chir2014，69，3： | 1 |
| 6 | Effects of antifibrotic agents on TGF-beta1, CTGF and IFN-gamma expression in patients with idiopathic pulmonary fibrosis显示文摘 | Tzortzaki EG Antoniou KM Zervou MI Lambiri I Koutsopoulos A Tzanakis N Plataki M Maltezakis G Bouros D Siafakas NM | 2007 | Respir Med2007，101，8： | 1 |
| 7 | Toxicity and Repellency of Hot Pepper Extracts to Spider Mite显示文摘 | ANTONIOUS G F MEYER J E SNYDER J C | 2006 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2006，41，8： | 1 |
| 8 | Predictive value of D-dimer plasma levels in response and progressive disease in patients with lung cancer显示文摘 | Antoniou D Pavlakou G Stathopoulos G P | 2006 | Lung Cancer2006，53，2： | 1 |
| 9 | Brain oxygen and metabolism during circulatory arrest with intermittent brief periods of low-flow cardiopulmonary bypass in newborn piglets显示文摘 | Antoni D Shears G | 2006 | J Thorac Cardiovasc Surg2006，132，4： | 1 |
| 10 | Negation and Negative In- formation in the W3C Resource Description Framework 显示文摘 | Analyti A Antoniou G Damasio C V | 2004 | Annals of Mathematics Computing & Teleinformatics (AMCT)2004，1，2： | 1 |
| 11 | Growing Hot Pepper for Cabbage Looper, Trichopulsia ni (Hubner) and Spidermite, Tetranychus urticae (Koch) Control显示文摘 | ANTONIOUS G F MEYER J E ROGERS J A | 2007 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2007，42，5： | 1 |
| 12 | 查看详情显示文摘 | Antoniou M G de la Cruz A A Dionysiou D D | | 0，，： | 1 |
| 13 | Rice xa13 recessive resistance to bacterial blight is defeated by induction of the disease susceptibility gene Os-11N3显示文摘 | Antony G Zhou J Huang S | 2010 | Plant Cell2010，22，11： | 1 |
| 14 | Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination显示文摘 | Antony JM van Marie G Opii W | 2004 | Nat Neurosci2004，7，10： | 1 |
| 15 | Modeling ground penetrating radar using gprMax 显示文摘 | Antonis G | 2005 | Construction and Building Material2005，19，10： | 1 |
| 16 | 查看详情显示文摘 | Antoniou M G de la Cruz A A Dionysiou D D | | 0，，： | 1 |
| 17 | Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rapture and Preterm Labor 显示文摘 | Piell'antoni E Del Chierico F Rigon G | 2014 | Int J Mol Sci2014，15，5： | 1 |
| 18 | Long-term consequences of early maternal deprivation in serotonergic activity and HPA function in adult rat 显示文摘 | Rentesi G Antoniou K Marselos M | 2010 | Neurosci Lett2010，480，1： | 1 |
| 19 | Vaginal hysterectomy : technique and results in the last twenty years 显示文摘 | Kologirou D Antoniou G Zioris C | 1995 | J Gynecol Surg1995，11，： | 1 |
| 20 | Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity显示文摘 | Antoniou J Demers CN Beaudoin G | 2004 | Magn Reson Imaging2004，22，7： | 1 |
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