|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 2 | Nontuberculous mycobacterial breast implant infections显示文摘 | Macadam Sheina A Mehling Blair M Fanning Anne | 2007 | Plastic & Reconstructive Surgery2007，119，1： | 1 |
| 3 | Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival.Recently,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated carcinogenesis.Mitochondrial dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of cancers.However,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely understood.The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our study.We show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free survival.Furthermore,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of NPC.Targeting Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC cells.In addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in NPC.Our findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine 637.Disruption of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 4 | Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC显示文摘 | Wei Liu Anne Le Chad Hancock Andrew N. Lane Chi V. Dang Teresa W.-M. Fan James M. Phang | 2012 | Proceedings of the National Academy of Sciences2012，，23： | 1 |
| 5 | A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK显示文摘 | Aroon D. Hingorani Chia Fan Liang Jenny Fatibene Amelia Lyon Sue Monteith Ann Parsons Stephen Haydock Ruth V. Hopper Nigel G. Stephens Kevin M. O’Shaughnessy Morris J. Brown | 1999 | Circulation1999，，14： | 1 |
| 6 | The admission systemic inflammatory response syndrome predicts outcome in patients undergoing emergency surgery显示文摘 | Anne Chao Wei-Han Chou Chee-Jen Chang Yu-Jr Lin Shou-Zen Fan An-Shine Chao | 2013 | Asian Journal of Surgery2013，，3： | 1 |
| 7 | Entecavir for Treatment of Lamivudine-Refractory, HBeAg-Positive Chronic Hepatitis B显示文摘 | Morris Sherman Cihan Yurdaydin Jose Sollano Marcelo Silva Yun–Fan Liaw Janusz Cianciara Anna Boron–Kaczmarska Paul Martin Zachary Goodman Richard Colonno Anne Cross Gail Denisky Bruce Kreter Robert Hindes | 2006 | Gastroenterology2006，，7： | 1 |
| 8 | A Contemporary, Population-Based Study of Lymphedema Risk Factors in Older Women with Breast Cancer显示文摘 | Tina W. F. Yen MS MD Xiaolin Fan PhD Rodney Sparapani MS Purushuttom W. Laud PhD Alonzo P. Walker MD Ann B. Nattinger MPH MD | 2009 | Annals of Surgical Oncology2009，，4： | 1 |
| 9 | Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds显示文摘 | Yannie O. Y. Soo Song Ran Yang Wynnie W. M. Lam Adrian Wong Yu Hua Fan Howan H. W. Leung Anne Y. Y. Chan Cecilia Leung Thomas W. H. Leung Lawrence K. S. Wong | 2008 | Journal of Neurology2008，，11： | 1 |
| 10 | Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells显示文摘 | Anne Le Andrew N. Lane Max Hamaker Sminu Bose Arvin Gouw Joseph Barbi Takashi Tsukamoto Camilio J. Rojas Barbara S. Slusher Haixia Zhang Lisa J. Zimmerman Daniel C. Liebler Robbert J.C. Slebos Pawel K. Lorkiewicz Richard M. Higashi Teresa W.M. Fan Chi V. | 2012 | Cell Metabolism2012，，1： | 1 |
| 11 | Excerpts from the United States Renal Data System 2004 Annual Data Report: Atlas of end-stage renal disease in the United States显示文摘 | Allan J. Collins Bertram Kasiske Charles Herzog Blanche Chavers Robert Foley David Gilbertson Richard Grimm Jiannong Liu Thomas Louis Willard Manning Arthur Matas Marshall McBean Anne Murray Wendy St. Peter Jay Xue Qiao Fan Haifeng Guo Shuling Li Suying L | 2005 | American Journal of Kidney Diseases2005，，： | 1 |
| 12 | Excerpts from the United States Renal Data System 2004 Annual Data Report: Atlas of end-stage renal disease in the United States显示文摘 | Allan J. Collins Bertram Kasiske Charles Herzog Blanche Chavers Robert Foley David Gilbertson Richard Grimm Jiannong Liu Thomas Louis Willard Manning Arthur Matas Marshall McBean Anne Murray Wendy St. Peter Jay Xue Qiao Fan Haifeng Guo Shuling Li Suying L | 2005 | American Journal of Kidney Diseases2005，，： | 1 |
| 13 | Ex Vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes显示文摘The brain tumor perivascular niche(PVN),the region in the vicinity of microvessels is a prime location for brain tumor stem-like cells(BTSCs)[1].Tumor microvasculature creates a complex microenvironment consisting of various cell types,the extracellular matrix,and soluble factors that mediate cell-cell interaction.The brain tumor PVN controls maintenance,expansion,and differentiation of BTSCs via direct cell contact or paracrine signaling cues.BTSCs often receive bidirectional crosstalk from endothelial cells and other cell types in the niche[2].In addition,the perivascular zone may serve as a path for tumor cells to migrate over long distances(3,4)Unlike other solid tumors,glioblastoma multiforme(GBM)cells rarely metastasize to other organs,but they can invade the entire brain by migrating along specific brain tissue structures,such as blood vessels or white matter tracts,leading to high rates of relapse.Despite the success in modeling diffuse brain tumors in both genetically-modified and patient-derived xenograft(PDX)animals,there is an unmet need for an in vitro system that can bridge conventional cell culture and animal models by mimicking not only the anatomy but also the function of the PVN to study the dynamics of BTSCs.In this presentation,I will describe the use of a microvasculature-on-a-chip system as a PVN model to evaluate the dynamics of BTSCs ex vivo from 10 glioblastoma patients [5].We observed that BTSCs preferentially localize in the perivascular zone.Live cell tracking showed that the cells residing in the vicinity of microvessels had the lowest motility,while a fraction of cells on the microvessels unexpectedly possessed the highest motility and migrated over the longest distance.These results indicate that the perivascular zone is a niche for BTSCs,while the microvascular tracks are also a path for long-distance tumor cell migration and invasion.Additionally,the degree of co-localization between tumor cells and microvessels varied significantly across patients.To validate the results from our microvasculature-on-a-chip system,we used single-cell transcriptome sequencing(10 patients and 21,750 single cells in total)to identify the subtype of each tumor cell.The co-localization coefficient was found to correlate positively with proneural(stem-like)or mesenchymal(invasive)but not classical(proliferative)tumor cells.Furthermore,we found that a gene signature profile including PDGFRA correlated strongly with the'homing'of brain tumor cells to the PVN.Our findings demonstrated that ex vivo dynamics of human brain tumor cells in a microvasculature-on-a-chip model can recapitulate in vivo tumor cell dynamics,heterogeneity,and subtypes,representing a new route to the study of human tumor cell biology and uncover patient-specific tumor cell functions.Acknowledgments:We thank Drs.Laura Niklason,Eric Holland,Franziska Michor,and Frank Szulzewsky for scientific discussion.We thank Misha Guy,Vladimir Polejaev,Zhenting Jiang,and Alice Yun for suggestions and help on the simulation computing and SEM/confocal imaging process.This research was supported by the Packard Fellowship for Science and Engineering(R.F.),National Science Foundation CAREER Award CBET-1351443(R.F.),U54 CA193461(R.F.),U54CA209992(Sub-Project ID:7297 to R.F.),R01 NS095817(J.Z.),Yale Cancer Center Co-Pilot Grant(to R.F.).The molds for microfluidic devices were fabricated in the Yale School of Engineering and Applied Science cleanroom.Sequencing was performed at the Yale Center for Genome Analysis(YCGA)facility.Data was analyzed at Yale High Performance Computing(HPC)center.Super resolution confocal imaging was performed at Yale Center for Cellular and Molecular Imaging(CCMI). | Yang Xiao Ann Tai Chen Jiangbing Zhou Rong Fan | 2019 | 医用生物力学2019，34，A01： | 1 |
| 14 | A Prospective and Randomized Comparison of Limited Versus Extensive Atrial Substrate Modification After Circumferential Pulmonary Vein Isolation in Nonparoxysmal Atrial Fibrillation显示文摘 | YENN‐JIANG LIN SHIH‐LIN CHANG LI‐WEI LO YU‐FENG HU ERIC CHONG TZE‐FAN CHAO FA‐PO CHUNG JONAN LIAO CHENG‐HUNG LI HSUAN‐MING TSAO TSAIR KAO YUN‐YU CHEN JIN‐LONG HUANG SHIH‐ANN CHEN | 2014 | J Cardiovasc Electrophysiol2014，，： | 1 |
| 15 | Influence of Age on Incident Diabetes and Cardiovascular Disease Among Prostate Cancer Survivors Receiving Androgen Deprivation Therapy显示文摘 | Alicia K. Morgans Kang-Hsien Fan Tatsuki Koyama Peter C. Albertsen Michael Goodman Ann S. Hamilton Richard M. Hoffman Janet L. Stanford Antoinette M. Stroup Matthew J. Resnick Daniel A. Barocas David F. Penson | 2014 | The Journal of Urology2014，，： | 1 |
| 16 | Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells显示文摘 | Anne Le Andrew N. Lane Max Hamaker Sminu Bose Arvin Gouw Joseph Barbi Takashi Tsukamoto Camilio J. Rojas Barbara S. Slusher Haixia Zhang Lisa J. Zimmerman Daniel C. Liebler Robbert J.C. Slebos Pawel K. Lorkiewicz Richard M. Higashi Teresa W.M. Fan Chi V. | 2012 | Cell Metabolism2012，，1： | 1 |
| 17 | Tuberculosis current and potential treatmet 显示文摘 | Anne Fanning | 1995 | Medical Progress SEA1995，22，8： | 1 |
| 18 | Simultaneous measurement of 16 bisphenol A analogues in house dust and evaluation of two sampling techniques显示文摘Bisphenol A(BPA)is a high production volume(HPV)chemical used to make polycarbonate(PC)plastics and epoxy resins.Due to its potential adverse health effects,BPA has been restricted or banned in some products and thus many alternatives to BPA have been introduced into the market.Most of these alternatives such as bisphenol S(BPS),bisphenol F(BPF),and bisphenol M(BPM),have similar chemical structures to BPA and termed as BPA analogues(BPAAs).In this study,a method was developed for the simultaneous determination of 16 BPAAs in indoor dust by gas chromatography coupled with tandem mass spectrometry(GC-MS/MS).The method was sensitive,with method detection limits(MDLs)ranging from 0.001 mg/g to 0.017 mg/g.The method demonstrated good recoveries(>80%)for the majority of the target compounds and was applied to the analysis of dust samples collected from 2007 to 2010 in 13 cities across Canada under the Canadian House Dust Study(CHDS).Samples were collected using two different techniques:household vacuum dust samples collected from household vacuum bags(HD);fresh vacuum dust(FD)samples collected by a trained technician from dry floor surfaces.In addition to BPA with 100%detection in 119 HD samples,BPS,BPF,and BPM were detected with high detection frequencies(>75%)with median(range)concentrations of 0.242(<0.017-35.1)mg/g,0.123(<0.007-2.67)mg/g,and 0.028(<0.005-0.908)mg/g,respectively,suggesting their wide use in various applications.Other BPAAs were not detected or detected with very low frequencies and at low levels.This study shows that BPAA concentrations in dust sampled from household vacuum bags compare well with concentrations observed in fresh dust collected from the same homes,suggesting that HD sampling could be a cost-effective alternative to FD sampling.The method was also applied to the analysis of a standard reference material e NIST SRM 2585(organic contaminants in house dust).So far there are no certified values for BPAAs in SRM 2585.In this study only three BPAAs were detected in SRM 2585,with mean values of 34.2(±2.3)mg/g for BPA,1.88(±0.22)mg/g for BPS,and 0.297(±0.052)mg/g for BPF. | Xinghua Fan Guru Prasad Katuri Amelia Anne Caza Pat E.Rasmussen Cariton Kubwabo | 2021 | Emerging Contaminants2021，7，1： | 1 |
| 19 | Effects of lactoferrin on intestinal epithelial cell growth and differentiation: an in vivo and in vitro study显示文摘 | Anne Blais Cuibai Fan Thierry Voisin Najat Aattouri Michel Dubarry Fran?ois Blachier Daniel Tomé | 2014 | BioMetals2014，，： | 1 |
| 20 | Correction:Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance显示文摘Correction to:Signal Transduction and Targeted Therapy(2020)5:56,http://gffzzd3cc09b8251d45dfsvnbkwb60vco66box.ffgz.tsg.suse.edu.cn/10.1038/s41392-020-0151-9,published online 20 May 2020 In this article1 an error was noticed in Fig.3d left(p-Drp1 Ser637).The images were misassigned.And one writing error was found in Fig.S1c.The correct figures are given.The authors confirm that these corrections do not change the result interpretation or conclusions of the article. | Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu Lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao Weizhong Wu Xin Zhang Weihua Liao Ann M.Bode Ya Cao | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员