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| 1 | Dendrimer-decorated nanogels:Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma显示文摘Nanomedicine has revolutionized disease theranostics by the accurate diagnosis and efficient therapy.Here,the PAMAM dendrimer decorated PVCL-GMA nanogels(NGs)were developed for favorable biodistribution in vivo and enhanced antitumor efficacy of ovarian carcinoma.By an ingenious design,the NGs with a unique structure that GMA-rich domains were localized on the surface were synthesized via precipitation polymerization.After G2 dendrimer decoration,the overall charge is changed from neutral to positive,and the NGs-G2 display the whole charge nature of positively charged corona and neutral core.Importantly,the unique architecture and charge conversion of NGs-G2 have a profound impact on the biodistribution and drug delivery in vivo.As a consequence of this alteration,the NGs-G2 as nanocarriers emerge the highly sought biodistribution of reduced liver accumulation,enhanced tumor uptake,and promoted drug release,resulting in the significantly augmented antitumor efficacy with low side effects.Remarkably,this finding is contrary to some reported work that the nanocarriers with positive charge have preferential liver uptake.Moreover,the NGs-G2 also displayed thermal/pH dual-responsive behaviors,excellent biocompatibility,improved cellular uptake,and stimuli-responsive drug release.Encouragingly,this work demonstrates a novel insight into the strategy for optimizing design,improving biodistribution and enhancing theranostic efficacy of nanocarriers. | Xin Li Zhijun Ouyang Helin Li Chaolei Hu Pabitra Saha Lingxi Xing Xiangyang Shi Andrij Pich | 2021 | Bioactive Materials2021，6，10： | 2 |
| 2 | Development of the integrating analog-to-Digital converter for distributive data acquisition systems with Improved noise immunity 显示文摘 | Roman Oleh Andrij | 2002 | IEEE Transactions on Instrumen-tation and Measurement2002，51，1： | 1 |
| 3 | A facile approach to fabrication of ZnO-TiO2 hollow spheres显示文摘 | Mukesh A Smrati G Andrij P | 2009 | Chem Mater2009，21，： | 1 |
| 4 | Fabrication of hollow titania microspheres with tailored shell thickness 显示文摘 | Mukesh A Andrij P Nikolaos E Z | 2008 | Colloid & Polymer Science2008，286，5： | 1 |
| 5 | Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy显示文摘For cancer nanomedicine,the main goal is to deliver therapeutic agents effectively to solid tumors.Here,we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels(CH-PPy NGs)for enhanced tumor delivery and augmented chemotherapy.CH was first grafted with PPy to form CH-PPy polymers that were used to form CH-PPy NGs through glutaraldehyde cross-linking via a miniemulsion method.The CH-PPy NGs could be finely treated with an alkaline solution to generate ultrafast charge-reversible CH-PPy-OH-4 NGs(R-NGs)with a negative charge at a physiological pH and a positive charge at a slightly acidic pH.The R-NGs display good cytocompatibility,excellent protein resistance,and high doxorubicin(DOX)loading efficiency.Encouragingly,the prepared R-NGs/DOX have prolonged blood circulation time,enhanced tumor accumulation,penetration and tumor cell uptake due to their self-adaptive charge switching to be positively charged,and responsive drug delivery for augmented chemotherapy of ovarian carcinoma in vivo.Notably,the tumor accumulation of R-NGs/DOX(around 4.7%)is much higher than the average tumor accumulation of other nanocarriers(less than 1%)reported elsewhere.The developed self-adaptive PPy-grafted CH NGs represent one of the advanced designs of nanomedicine that could be used for augmented antitumor therapy with low side effects. | Xin Li Helin Li Changchang Zhang Andrij Pich Lingxi Xing Xiangyang Shi | 2021 | Bioactive Materials2021，6，10： | 1 |
| 6 | Determination of Pb in the ash fraction of plants and peats using the Energy-dispersive Miniprobe Multielement Analyser (EMMA) 显示文摘 | DOMINKK WEISS ANDRIJ CHEBURKIN | 1998 | The Analysis1998，123，： | 1 |
| 7 | Template-assisted fabrication of magnetically responsive hollow titania capsules显示文摘 | Mukesh Agrawal Smrati Gupta Andrij Pich | 2010 | Langmuir2010，26，17： | 1 |
| 8 | Application of the fault tree analysis for assessment of power system reliability显示文摘 | Andrij a Volkanovski Bomt Mavko | 2009 | Relia- bility Engineering and System Safety2009，，1： | 1 |
| 9 | Simulation and approximate formulae for the radial distribution functions of highly asymmetric hard sphere mixtures显示文摘 | Douglas Henderson Andrij Trokhymchuk Leslie V. Woodcock Kwong-Yu Chan | 2005 | Molecular Physics2005，，5： | 1 |
| 10 | Computer simulations of liquid/Vapor interface in lennard-Jones fluids: some questions and answers显示文摘 | ANDRIJ T JOSE A | 1999 | J Chem Phys1999，111，18： | 1 |
| 11 | Immunoglobulin and Lymphocyte Responses Following Silica Exposure in New Zealand Mixed Mice显示文摘 | Jared M. Brown Jean C. Pfau Andrij Holian | 2004 | Inhalation Toxicology2004，，3： | 1 |
| 12 | Effect of the Reaction Field on Molecular Forces and Torques Revealed by an Image-Charge Solvation Model显示文摘We recently developed the Image-Charge Solvation Model(ICSM),which is an explicit/implicit hybrid model to accurately account for long-range electrostatic forces in molecular dynamics simulations[Lin et al.,J.Chem.Phys.,131,154103,2009].The ICSM has a productive spherical volume within the simulation cell for which key physical properties of bulk water are reproduced,such as density,radial distribution function,diffusion constants and dielectric properties.Although the reaction field(RF)is essential,it typically accounts for less than 2% of the total electrostatic force on a water molecule.This observation motivates investigating further the role of the RF within the ICSM.In this report we focus on distributions of forces and torques on water molecules as a function of distance from the origin and make extensive tests over a range of model parameters where Coulomb forces are decomposed into direct interactions from waters modeled explicitly and the RF.Molecular torques due to the RF typically account for 20% of the total torque,revealing why the RF plays an important role in the dielectric properties of simulated water.Moreover,it becomes clear that the buffer layer in the ICSM is essential to mitigate artifacts caused by the discontinuous change in dielectric constants at the explicit/implicit interface. | Wei Song Yuchun Lin Andrij Baumketner Shaozhong Deng Wei Cai Donald JJacobs | 2013 | Communications in Computational Physics2013，13，1： | 0 |
| 13 | Element selection for functional materials discovery by integrated machine learning of elemental contributions to properties显示文摘The unique nature of constituent chemical elements gives rise to fundamental differences in materials.Assessing materials based on their phase fields,defined as sets of constituent elements,before specific differences emerge due to composition and structure can reduce combinatorial complexity and accelerate screening,exploiting the distinction from composition-level approaches.Discrimination and evaluation of novelty of materials classes align with the experimental challenge of identifying new areas of chemistry.To address this,we present PhaseSelect,an end-to-end machine learning model that combines representation,classification,regression and novelty ranking of phase fields.PhaseSelect leverages elemental characteristics derived from computational and experimental materials data and employs attention mechanisms to reflect the individual element contributions when evaluating functional performance of phase fields.We demonstrate this approach for high-temperature superconductivity,high-temperature magnetism,and targeted bandgap energy applications,showcasing its versatility and potential for accelerating materials exploration. | Andrij Vasylenko Dmytro Antypov Vladimir V.Gusev Michael W.Gaultois Matthew S.Dyer Matthew J.Rosseinsky | 2023 | npj Computational Materials2023，，1： | 0 |
| 14 | Flexural Behavior of 3D Printed Concrete Beam with Fiber Reinforcement显示文摘3D printing with concrete is a promising new method for rapid,low cost construction.The flexural strengths for reinforced/unreinforced and 3D printed/cast concrete Warren trusses were tabulated and the failure mechanisms were reported.The types of reinforcement used were rebar(basalt and steel),and mesh(basalt and aramid).The effect of loading geometry and loading speed was measured for basalt mesh and aramid mesh composite,respectively.Due to the expected variation in flexure between samples,it cannot be said whether small differences for various tests are significant.Variation stems from a microscopically uneven surface and random inhomogeneities in the bulk of the tested material which act as a microcrack catalyst and propagator.Since the tested beams are short specimens the numerical findings of other studies will vary based on the intended design.This paper is intended to assess the performance of various reinforcements in a qualitative sense by comparing basalt reinforcement with other reinforcements.It was found that cast beams tolerated deflection better but had a similar flexure strength compared as the printed beams.The steel and basalt rebar reinforced beams had the highest flexure strengths where the traditional steel rebar reinforcement outperformed the basalt in flexure by 36%and the basalt outperformed the steel in deflection by 40%.The basalt mesh outperformed the cast and printed unreinforced bars by a small margin but had only 25%of steel rebars’deflection at maximum flexure strength.The aramid mesh tolerated the biggest deflection out of any sample at 2.26 cm. | Ghassan K Al-Chaar Andrij Kozych | 2020 | Journal of Construction Research2020，2，2： | 0 |
| 15 | A database of experimentally measured lithium solid electrolyte conductivities evaluated with machine learning显示文摘The application of machine learning models to predict material properties is determined by the availability of high-quality data.We present an expert-curated dataset of lithium ion conductors and associated lithium ion conductivities measured by a.c.impedance spectroscopy.This dataset has 820 entries collected from 214 sources;entries contain a chemical composition,an expert-assigned structural label,and ionic conductivity at a specific temperature(from 5 to 873°C).There are 403 unique chemical compositions with an associated ionic conductivity near room temperature(15–35°C).The materials contained in this dataset are placed in the context of compounds reported in the Inorganic Crystal Structure Database with unsupervised machine learning and the Element Movers Distance.This dataset is used to train a CrabNet-based classifier to estimate whether a chemical composition has high or low ionic conductivity.This classifier is a practical tool to aid experimentalists in prioritizing candidates for further investigation as lithium ion conductors. | Cameron J.Hargreaves Michael W.Gaultois Luke M.Daniels Emma J.Watts Vitaliy A.Kurlin Michael Moran Yun Dang Rhun Morris Alexandra Morscher Kate Thompson Matthew A.Wright Beluvalli-Eshwarappa Prasad Frédéric Blanc Chris M.Collins Catriona A.Crawford Benjamin B.Duff Jae Evans Jacinthe Gamon Guopeng Han Bernhard T.Leube Hongjun Niu Arnaud J.Perez Aris Robinson Oliver Rogan Paul M.Sharp Elvis Shoko Manel Sonni William J.Thomas Andrij Vasylenko Lu Wang Matthew J.Rosseinsky Matthew S.Dyer | 2023 | npj Computational Materials2023，，1： | 0 |
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