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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 3 | Treatment of Sleep Problems in a 5-year-old Boy with Autism Using Behavioural Principles显示文摘 | Sophie W Jan M Amanda R | 2001 | Autism2001，，2： | 1 |
| 4 | Demonstration of TCDD-attenuated P450 steroidogenic enzyme mRNA levels in rat granulosa cells in vitro using competitive RT-PCR显示文摘 | Asok K D Barbara A B W Amanda L T | 2000 | Mol Cell Endocrinol2000，164，： | 1 |
| 5 | Changes in meth- ylation patterns of Kissl and Kisslr gene promoters across puberty 显示文摘 | Amanda K W Monika Z Jean L V | 2013 | Genetics - Epigeneties2013，5，： | 1 |
| 6 | Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure显示文摘 | Agarwal Udit Smith Amanda W | 2015 | Stem Cells Translational Medicine2015，5，： | 1 |
| 7 | Spectro-electrochemical characterization of nanostructured mesoporous manganese oxide in aqueous electrolytes 显示文摘 | Jeffrey W L Amanda L Y Debra R R | 2003 | J Electrochem Soc2003，150，9： | 1 |
| 8 | Association of glycaemia with macrovasular and microvasular complications of type 2 diabetes prospective observational study 显示文摘 | IRENE M Stratton Amanda I Adler H Andrew W Neil | 2000 | BMJ2000，321，8： | 1 |
| 9 | Amylose determination of native high amylose corn starches by differential scanning calorimetry 显示文摘 | Nathan W P Amanda L W Mark R C | 2005 | Starch/Starke2005，，57： | 1 |
| 10 | Two WD-repeat genes from cotton are functional homologues of the Arabidopsis thaliana transparent testa glabra1(TTG1) gene显示文摘 | John A H Amanda R W Jeremy N T | 2005 | Plant Molecular Biology2005，57，： | 1 |
| 11 | Cloning and characterization of the vermilion gene of Drosophila melanogaster显示文摘 | Amanda R W Howells A J Tearle R G | 1986 | Mol Gen Genet1986，202，： | 1 |
| 12 | Cavitation of a submerged jet 显示文摘 | Vlichael M W Brenden E Amanda D | 2013 | Experiments in Fluids2013，54，： | 1 |
| 13 | Journal of the Taiwan Institute of Chemical Engineers显示文摘 | Tung G H Chang J H Hsieh Y H Hsu J C Amanda V E Liu W C Yan R H | 2014 | 798 : 12014，798，： | 1 |
| 14 | Seroepidemiologic and occupational risk survey for Coxiella burnetii antibodies among US veterinarians显示文摘 | Ellen A S W Robert F M Amanda J C | 2009 | Clinical Infectious Diseases2009，，： | 1 |
| 15 | Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience显示文摘 | Matthias Pfisterer Jafna L Cox Christopher B Granger Sorin J Brener C.David Naylor Robert M Califf Frans van de Werf Amanda L Stebbins Kerry L Lee Eric J Topol Paul W Armstrong | 1998 | Journal of the American College of Cardiology1998，，3： | 1 |
| 16 | The effica- cy of dusting honey bee colonies with powdered sugar to reduce varroa mite populations 显示文摘 | Amanda M Ellisa Gerry W Hayesa James D EUisb | 2009 | Journal of Apicultural Research2009，48，1： | 1 |
| 17 | Association of Systolic Blood Pressure with Macrovascular and Microvascular Complication of Type 2 Diabetes(UKPDS 36):Prospective Observational Study显示文摘 | Amanda I A Stratton I M Neil H A W | 2000 | British Medical Journal2000，321，： | 1 |
| 18 | Visual journaling:an intervention to influence stress,anxiety and affect levels in medical students显示文摘 | Amanda M Elizabeth W | 2010 | The Arts in Psychotherapy2010，37，： | 1 |
| 19 | The Knoevenagel reaction:analysis and recycling of the ionic liquid medium显示文摘 | David C F Amanda M L Doug W M | 2006 | Tetrahedron Lett2006，47，： | 1 |
| 20 | Speetro-electrochemical characterization of nanostruetured mesoporous manganese oxide in aqueous electrolytes 显示文摘 | Jeffrey W Long Amanda L Young Debra R Rolison | 2003 | J Electrochem Soc2003，150，9： | 1 |
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