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| 1 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 2 | Management of lateral neck masses in adults显示文摘 | Michael G Amanda H Aurelia R | 2000 | BMJ2000，320，3： | 1 |
| 3 | Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels 显示文摘 | Virginia J Y Michael G O Amanda S | 2006 | Cancer Res2006，66，5： | 1 |
| 4 | Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?显示文摘In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning goals.Pediatricians may play a key role in helping children access special education services.The number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to 2021.Children receiving special education services under the autism category increased 242%during the same period.The demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%respectively.Although student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by 2021.Allowable heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing processes.Numerous clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder epidemics.Dietary heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across generations.In 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative action.Mandatory health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations. | Renee J Dufault Raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt | 2023 | World Journal of Clinical Pediatrics2023，12，2： | 1 |
| 5 | Aspirin for elective hip and knee arthroplasty: a multimodel thromboprophylaxis protocol 显示文摘 | Errore V Mark G Amanda E | 2012 | Interna- tional Orthopaedics2012，36，10： | 1 |
| 6 | Preselection based on clinical characteristics in german non smal显示文摘 | Amanda L H Martin E Fernando G | 2014 | J Thorac 0ncol2014，9，1： | 1 |
| 7 | Rational primer design greatly improves differential display-PCR (DDPCR) 显示文摘 | DANIEL G AMANDA G F MERKENSCHLAGER M | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 8 | On target classification using kinematic data显示文摘 | Branko R Neil G Amanda B | 2004 | Information Fusion2004，12，5： | 1 |
| 9 | Expression of Distinct Self-Incompatibility Specificities in Arabidopsis thaliana显示文摘 | Boggs Nathan A Dwyer Kathleen G Shah Paurush McCulloch Amanda A Bechsgaard Jesper Schierup Mikkel H Nasrallah Mikhail E Nasrallah June B | 2009 | Genetics2009，，4： | 1 |
| 10 | Prepulse inhibition deficits in GAD65 knockout mice and the effect of antipsychotic treatment显示文摘 | Scott AH Amanda G Kerry JR | 2004 | Neuropsychopharmacology2004，29，： | 1 |
| 11 | Protozoan parasites in captive chinchillas (Chinchilla lanigera) raised in the State of Rio Grande do Sul,Brazil显示文摘 | ANA C F G AMANDA D S S | 2005 | Parasitol Latinoam2005，60，34： | 1 |
| 12 | Genetic Diversity and Phylogeny of Toxic Cyanobacteria Determined by DNA Polymorphisms within the PhycocyaninLocus显示文摘 | Daniel J Amanda E G | 1995 | Applied And Environmental Microbiology1995，61，11： | 1 |
| 13 | Cloning and characterization of the vermilion gene of Drosophila melanogaster显示文摘 | Amanda R W Howells A J Tearle R G | 1986 | Mol Gen Genet1986，202，： | 1 |
| 14 | The Pseudorabies virus Us2 protein,a virion tegument component,is prenylated in infected cells显示文摘 | Amanda C Clase Mathew G Lyman | 2003 | Virol2003，，12： | 1 |
| 15 | Sudden death in hypertrophic cardiomyopathy: identification of high risk patients显示文摘 | Perry M Elliott Jan Poloniecki Shaughan Dickie Sanjay Sharma Lorenzo Monserrat Amanda Varnava Niall G Mahon William J McKenna | 2000 | Journal of the American College of Cardiology2000，，7： | 1 |
| 16 | Journal of the Taiwan Institute of Chemical Engineers显示文摘 | Tung G H Chang J H Hsieh Y H Hsu J C Amanda V E Liu W C Yan R H | 2014 | 798 : 12014，798，： | 1 |
| 17 | Solubility of benzoic acid in mixed solvents显示文摘 | Amanda Oliveira C Coelho Marcia G Pires Ricardo F et al | 2007 | J Chem Eng Data2007，52，： | 1 |
| 18 | Models for cell loading and product sequencing in labor-intensive cells 显示文摘 | Stier G A Jeremy Cosner Amanda Patten | 2009 | Computers & Industrial Engineering2009，56，： | 1 |
| 19 | Situational specificity of trait in- fluences on drivers' evaluations and driving behaviour 显示文摘 | Amanda N S John A G | 2009 | Transportation Research Part F2009，12，1： | 1 |
| 20 | Effect of omapatrilat on systemic arterial functional in patients with chronic heart failure显示文摘 | Dougal R M Hamid I Amanda H G | 2001 | Am J Cardiol2001，87，3： | 1 |
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