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| 1 | Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，7： | 33 |
| 2 | Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: A meta-analysis显示文摘AIM: To undertake a meta-analysis on the value of urinary trypsinogen activation peptide (uTAP) in predicting severity of acute pancreatitis on admission. METHODS: Major databases including Medline, Embase, Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in the Cochrane Library were searched to identify all relevant studies from January 1990 to January 2013. Pooled sensitivity, specificity and the diagnostic odds ratios (DORs) with 95%CI were calculated for each study and were compared to other systems/biomarkers if mentioned within the same study. Summary receiver-operating curves were conducted and the area under the curve (AUC) was evaluated. RESULTS: In total, six studies of uTAP with a cut-off value of 35 nmol/L were included in this meta-analysis. Overall, the pooled sensitivity and specificity of uTAP for predicting severity of acute pancreatitis, at time of admission, was 71% and 75%, respectively (AUC = 0.83, DOR = 8.67, 95%CI: 3.70-20.33). When uTAP was compared with plasma C-reactive protein, the pooled sensitivity, specificity, AUC and DOR were 0.64 vs 0.67, 0.77 vs 0.75, 0.82 vs 0.79 and 6.27 vs 6.32, respectively. Similarly, the pooled sensitivity, specificity, AUC and DOR of uTAPvs Acute Physiology and Chronic Health Evaluation Ⅱ within the first 48 h of admission were found to be 0.64 vs 0.69, 0.77 vs 0.61, 0.82 vs 0.73 and 6.27vs 4.61, respectively. CONCLUSION: uTAP has the potential to act as a stratification marker on admission for differentiating disease severity of acute pancreatitis. | Wei Huang Kiran Altaf Tao Jin Jun-Jie Xiong Li Wen Muhammad A Javed Marianne Johnstone Ping Xue Christopher M Halloran Qing Xia | 2013 | World Journal of Gastroenterology2013，19，28： | 7 |
| 3 | Curcumin,a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase,represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin显示文摘 | Balasubramanyam K Varier R A Altaf M | 2004 | J Biol Chem2004，279，51： | 1 |
| 4 | Polyisoprenylated benzophenone,garcinol,a natural histone acetyltransferase inhibitor,represses chromatin transcription and alters global gene expression显示文摘 | Balasubramanyam K Altaf M Varier R A | 2004 | J Biol Chem2004，279，33： | 1 |
| 5 | Household demand for improved solid waste management:a case study of Gujranwala,Pakistan显示文摘 | Altaf M A Deshazo J R | 1996 | World Development1996，，5： | 1 |
| 6 | Host adaptation and host–parasite co-evolution in Cryptosporidium : implications for taxonomy and public health显示文摘 | Lihua Xiao Irshad M Sulaiman Una M Ryan Ling Zhou Edward R Atwill Monica L Tischler Xichen Zhang Ronald Fayer Altaf A Lal | 2002 | International Journal for Parasitology2002，，14： | 1 |
| 7 | Effect of handwashing on child health: a randomized controlled trial显示文摘 | Luby SP Agboatwalla M Feikin DR Painter J Billhimer W Altaf A | 2005 | Lancet2005，366，： | 1 |
| 8 | Cystic renal cell carcinoma arising from multilocular cystic nephroma of the same kidney显示文摘 | AHMAD M ALTAF Q JOHN A | 2006 | Int Braz J Urol2006，32，2： | 1 |
| 9 | Blasto-cyst injection of wild type embryonic stem cells induces global corrections in mdx mice显示文摘 | Stillwell E Vitale J Zhao Q.S Beck A Schneider J Khadim F Elson G Altaf A Yehia G Dong J.H Liu J Mark W Bhaumik M Grange R and Fraidenraich D | | 0，，03： | 1 |
| 10 | Unstable metacarpal and phalangeal fractures:treatment by internal fixation using AO mini-fragment plates and screws显示文摘 | Mohammad U M Muneer A F Altaf A R | 2010 | Ulus Travma Acil Cerrahi Derg2010，16，4： | 1 |
| 11 | Temporal and spatial variability of soil respiration in a boreal mixed wood forest显示文摘 | MYROSLAVA K ALTAF A M MCCAUGHEY J H | 2006 | Agricultural and Forest Meteorology2006，140，： | 1 |
| 12 | Effects of dietary protein level on spawning performance of Nile tilapia ( Oreochromis niloticus) broodstock reared at different water salinities 显示文摘 | Abdel M E Cathrine R M Altaf A E | 2003 | Aquaculture2003，220，14： | 1 |
| 13 | Production of xylanase enzyme by Pleurotus eryngii and Flamulina velutipes grown on different carbon sources under submerged fermentation 显示文摘 | Altaf S A Umar D M Muhammad M S | 2010 | World Applied Sciences Journal2010，，8： | 1 |
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