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| 1 | Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases显示文摘One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth factor(NGF), brain-derived neurotrophic factor(BDNF), neurotrophin-3(NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a dizzying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body's largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobiology and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic(atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric(e.g., Alzheimer's disease and depression) diseases. The present review updates evidence for(1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and(2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 receptor up-regulation. This may help to construct a novel paradigm in the field of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF. | Stanislav Yanev Luigi Aloe Marco Fiore George N Chaldakov | 2013 | World Journal of Pharmacology2013，2，4： | 2 |
| 2 | (iii)Arthroscopy of the foot and ankle显示文摘 | Anagnostopoulos D Bali N Alo K | 2014 | Orthop Trauma2014，28，1： | 1 |
| 3 | Western blot-indetermi- nate results in Nigerian patients HIV serodiagnosis: the clini- cal and public health implication显示文摘 | Uneke C J Alo M N Orbu O | 2007 | AIDS Patient Care STDS2007，21，： | 1 |
| 4 | A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3beta- hydroxysteroid dehydrogenase deficiency in 46, XX and 46,XY French- Canadians : evaluation of gonadal function after puberty 显示文摘 | Alos N Moisan AM Ward L | 2000 | J Clin Endocrinol Metab2000，85，5： | 1 |
| 5 | High incidence of vertebral fractures in children with acute lymphoblastic leu- kemia 12 months after the initiation of therapy 显示文摘 | Alos N Grant RM Ramsay T | 2012 | J Clin Oncol2012，30，： | 1 |
| 6 | Western blot-Indeterminate results in Nigerian patients HIV serodiagnosis:the clinical and public health implication显示文摘 | UNEKE C J ALO M N OGBU O | 2007 | AIDS Patient Care STDS2007，21，3： | 1 |
| 7 | CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (pTZ)-treated adult rats 显示文摘 | Tirassa P Costa N Aloe L | 2005 | Neuropharmacolngy2005，48，5： | 1 |
| 8 | An analysis of hand-held doppler knowledge and accuracy in lower limb arterial perforator assessment 显示文摘 | Karkhanis S Bali N Alo K | 2011 | J Plast Reconstr Aesthet Surg2011，64，4： | 1 |
| 9 | CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus ofpentylenetetrazole (PTZ)-treated adult rats显示文摘 | Tirassa P Costa N Aloe L | 2005 | Neuropharmacology2005，48，5： | 1 |
| 10 | CCK8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus ofpentylenetetrazole (PTZ)-treated adult rats显示文摘 | Tirassa P Costa N Aloe L | 2005 | Neuropharmacology2005，48，5： | 1 |
| 11 | Can Insurers Pay for the 'Big One' ? Measuring the Capacity of an Insurance Market to Respond to Catastrophic Losses显示文摘 | Cummins J D Doherty N ALo | 2002 | Journal of Banking and Finance2002，26，： | 1 |
| 12 | The role of Re and S in the Pt-Re-S/Al2O3 catalyst显示文摘 | PAREA J M BELTRAMINI J N QUERINI C A MARTINELLI E E CHURIN E J ALOE P E FIGOLI N S | 1986 | J Catal1986，99，1： | 1 |
| 13 | The elect of bone quality on the stability of ankle arthrodesis显示文摘 | Alo n so-Vazqu ez A Lauge-Pedersen H Lidgren L | 2004 | A finite element study Foot Ankle Int2004，25，11： | 1 |
| 14 | Coin-flipping games immune against linearsized coalitions 显示文摘 | Alo N Naor M | 1995 | SIAM Journal on Computing1995，222，： | 1 |
| 15 | Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors显示文摘 | Caroleo MC Costa N Aloe L | 2001 | Neuroimmunol2001，113，2： | 1 |
| 16 | Western blot-indeterminate results in Nigerian patients HIV serodiagnosis: the clinical and public health implication 显示文摘 | Uneke C J Alo M N Ogbu O | 2007 | AIDS Patient Care STDS2007，21，3： | 1 |
| 17 | A novel A10E homozygous mutation in the HSD3B2 gene causing severe salt-wasting 3-hydroxysteroid dehydrogenase deficiency in 46,XX and 46,XY French-Canadians:evaluation of gonadal function after puberty显示文摘 | Alos N Moisan AM Ward L | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 18 | Do estrogens impact adolescent idiopathic scoliosis 显示文摘 | Leboeuf D Letellier K Alos N | 2009 | Trends Endocrinol Metab2009，20，4： | 1 |
| 19 | Downregulation of osteoblasl Phex expression by PTH显示文摘 | Alos N Ecarot B | 2005 | Bone2005，37，4： | 1 |
| 20 | Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis显示文摘 | Chaldakov G N Stankulov I S Fiore M Ghenev P I Aloe L | 2001 | Atherosclerosis2001，159，： | 1 |
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